Intrinsic Limits on the Detection of the Anisotropies of the Stochastic Gravitational Wave Background.

For any given network of detectors, and for any given integration time, even in the idealized limit of negligible instrumental noise, the intrinsic time variation of the isotropic component of the stochastic gravitational wave background (SGWB) induces a limit on how accurately the anisotropies in the SGWB can be measured. We show here how this sample limit can be calculated and apply this to three separate configurations of ground-based detectors placed at existing and planned sites. Our results show that in the idealized, best-case scenario, individual multipoles of the anisotropies at ℓ≤8 can only be measured to ∼10^{-5}-10^{-4} level over five years of observation as a fraction of the isotropic component. As the sensitivity improves as the square root of the observation time, this poses a very serious challenge for measuring the anisotropies of SGWB of cosmological origin, even in the case of idealized detectors with arbitrarily low instrumental noise.

HCV point-of-care screening programme and treatment options for people who use drugs in a metropolitan area of Southern Italy.

BACKGROUND AND AIMS: People who use drugs (PWUD) represent an active reservoir of HCV infection. The prevalence of chronic HCV infection in PWUD in Italy remains unknown because of the lack of systematic screening. Thanks to direct-acting antiviral agents (DAAs), hepatitis C can now be cured in most patients. Thus, the next challenge is to provide linkage-to-care for these patients. METHODS: In this scenario, we conducted a screening programme in PWUD attending seven Addiction Centers in Southern Italy, as well as a treatment programme in the Liver Unit of the University Hospital of Salerno. We used the OraQuick HCV antibody test to screen the PWUD (from 1 April to 30 September 2018). RESULTS: 593 subjects were consecutively enrolled in the programme; 250 (41.8%) were HCV-Ab-positive. 143 (24.1%) were aware of their infection and had been HCV-RNA-tested: 83 were positive and 60 negative. The remaining 107 subjects (18.1%) had never previously been tested and were unaware of their infection. A total of 160 (26.9%) HCV RNA-positive patients were found and offered antiviral therapy with DAAs. The sustained virological response rate was 98.5% and no adverse events were recorded. Two patients voluntarily discontinued treatment. No reinfections have been recorded to date. CONCLUSIONS: The prevalence of HCV-Ab positivity was high in the PWUDs enrolled in this study, and almost half the patients were unaware of being HCV-positive. The linkage-to-care provided was safe and effective, and no case of reinfection was recorded.

Gravitational-Wave Background Sky Maps from Advanced LIGO O1 Data.

We integrate the publicly available O1 LIGO time-domain data to obtain maximum-likelihood constraints on the gravitational-wave background (GWB) arising from stochastic, persistent signals. Our method produces sky maps of the strain intensity I as a function of direction on the sky at a reference frequency f_{0}. The data are integrated assuming a set of fixed power-law spectra for the signal. The maps provide upper limits on the amplitude of the GWB density Ω_{GW}(f_{0}) and any anisotropy around the background. We find 95% confidence upper limits of Ω_{GW}<4.8×10^{-7} at f_{0}=50 Hz with similar constraints on a dipole modulation for the inspiral-dominated stochastic background case.

A cryogenic rotation stage with a large clear aperture for the half-wave plates in the Spider instrument.

We describe the cryogenic half-wave plate rotation mechanisms built for and used in Spider, a polarization-sensitive balloon-borne telescope array that observed the cosmic microwave background at 95 GHz and 150 GHz during a stratospheric balloon flight from Antarctica in January 2015. The mechanisms operate at liquid helium temperature in flight. A three-point contact design keeps the mechanical bearings relatively small but allows for a large (305 mm) diameter clear aperture. A worm gear driven by a cryogenic stepper motor allows for precise positioning and prevents undesired rotation when the motors are depowered. A custom-built optical encoder system monitors the bearing angle to an absolute accuracy of ±0.1(∘). The system performed well in Spider during its successful 16 day flight.

Rotation of galaxies as a signature of cosmic strings in weak lensing surveys.

Vector perturbations sourced by topological defects can generate rotations in the lensing of background galaxies. This is a potential smoking gun for the existence of defects since rotation generates a curl-like component in the weak lensing signal which is not generated by standard density perturbations at linear order. This rotation signal is calculated as generated by cosmic strings. Future large scale weak lensing surveys should be able to detect this signal even for string tensions an order of magnitude lower than current constraints.

Instability of anisotropic cosmological solutions supported by vector fields.

Models with vector fields acquiring a nonvanishing vacuum expectation value along one spatial direction have been proposed to sustain a prolonged stage of anisotropic accelerated expansion. Such models have been used for realizations of early time inflation, with a possible relation to the large scale cosmic microwave background anomalies, or of the late time dark energy. We show that, quite generally, the concrete realizations proposed so far are plagued by instabilities (either ghosts or unstable growth of the linearized perturbations) which can be ultimately related to the longitudinal vector polarization present in them. Phenomenological results based on these models are therefore unreliable.

Anomalous cosmic-microwave-background polarization and gravitational chirality.

We consider the possibility that gravity breaks parity, with left and right-handed gravitons coupling to matter with a different Newton's constant and show that this would affect their zero-point vacuum fluctuations during inflation. Should there be a cosmic background of gravity waves, the effect would translate into anomalous cosmic microwave background polarization. Nonvanishing temperature-magnetic (TB) mode [and electric-magnetic mode] components emerge, revealing interesting experimental targets. Indeed, if reasonable chirality is present a TB measurement would provide the easiest way to detect a gravitational wave background. We speculate on the theoretical implications of such an observation.

Cosmic microwave background snapshots: pre-WMAP and post-WMAP.

We highlight the remarkable evolution in the cosmic microwave background (CMB) power spectrum C(l) as a function of multipole l over the past few years, and in the cosmological parameters for minimal inflation models derived from it: from anisotropy results before 2000; in 2000 and 2001 from Boomerang, Maxima and the Degree Angular Scale Interferometer (DASI), extending l to approximately 1000; and in 2002 from the Cosmic Background Imager (CBI), Very Small Array (VSA), ARCHEOPS and Arcminute Cosmology Bolometer Array Receiver (ACBAR), extending l to approximately 3000, with more from Boomerang and DASI as well. Pre-WMAP (pre-Wilkinson Microwave Anisotropy Probe) optimal band powers are in good agreement with each other and with the exquisite one-year WMAP results, unveiled in February 2003, which now dominate the l less, similar 600 bands. These CMB experiments significantly increased the case for accelerated expansion in the early Universe (the inflationary paradigm) and at the current epoch (dark energy dominance) when they were combined with "prior" probabilities on the parameters. The minimal inflation parameter set, [omega(b), omega(cdm), Omega(tot), Omega(Lambda), n(s), tau(C), sigma(8)], is applied in the same way to the evolving data. C(l) database and Monte Carlo Markov Chain (MCMC) methods are shown to give similar values, which are highly stable over time and for different prior choices, with the increasing precision best characterized by decreasing errors on uncorrelated "parameter eigenmodes". Priors applied range from weak ones to stronger constraints from the expansion rate (HST-h), from cosmic acceleration from supernovae (SN1) and from galaxy clustering, gravitational lensing and local cluster abundance (LSS). After marginalizing over the other cosmic and experimental variables for the weak + LSS prior, the pre-WMAP data of January 2003 compared with the post-WMAP data of March 2003 give Omega(tot) = 1.03(-0.04)(+0.05) compared with 1.02(-0.03)(+0.04), consistent with (non-Baroque) inflation theory. Adding the flat Omega(tot) = 1 prior, we find a nearly scale-invariant spectrum, n(s) = 0.95(-0.04)(+0.07) compared with 0.97(-0.02)(+0.02). The evidence for a logarithmic variation of the spectral tilt is less than or approximately 2sigma. The densities are for: baryons, omega(b) identical with Omega(b)h(2) = 0.0217(-0.002)(+0.002) (compared with 0.0228(-0.001)(+0.001)), near the Big Bang nucleosynthesis (BBN) estimate of 0.0214 +/- 0.002; CDM, omega(cdm) = Omega(cdm)h(2) = 0.126(-0.012)(+0.012) (compared with 0.121(-0.010)(+0.010)); the substantial dark (unclustered) energy, Omega(Lambda) approximately 0.66(-0.09)(+0.07) (compared with 0.70(-0.05)(+0.05)). The dark energy pressure-to-density ratio w(Q) is not well constrained by our weak + LSS prior, but adding SN1 gives w(Q) less than or approximately -0.7 for January 2003 and March 2003, consistent with the w(Q) = -1 cosmological constant case. We find sigma(8) = 0.89(-0.07)(+0.06) (compared with 0.86(-0.04)(+0.04)), implying a sizable Sunyaev-Zel'dovich (SZ) effect from clusters and groups; the high-l power found in the January 2003 data suggest sigma(8) approximately 0.94(-0.16)(+0.08) is needed to be SZ-compatible.

Joint cosmic microwave background and weak lensing analysis: constraints on cosmological parameters.

We use cosmic microwave background (CMB) observations together with the red-sequence cluster survey weak lensing results to derive constraints on a range of cosmological parameters. This particular choice of observations is motivated by their robust physical interpretation and complementarity. Our combined analysis, including a weak nucleosynthesis constraint, yields accurate determinations of a number of parameters including the amplitude of fluctuations sigma(8)=0.89+/-0.05 and matter density Omega(m)=0.30+/-0.03. We also find a value for the Hubble parameter of H(0)=70+/-3 km s(-1) Mpc(-1), in good agreement with the Hubble Space Telescope key-project result. We conclude that the combination of CMB and weak lensing data provides some of the most powerful constraints available in cosmology today.