RESUMO
'The Mouse (Mus musculus) T Cell Receptor Delta Variable (TRDV), Diversity (TRDD) and Joining (TRDJ) Genes', the 15th report of the 'IMGT Locus in Focus' section, comprises 7 tables entitled: (1) 'Number of mouse (Mus musculus) germline TRDV genes at 14D1-D2 and potential repertoire'; (2) 'Mouse (Mus musculus) germline TRDV genes at 14D1-D2'; (3) 'Mouse (Mus musculus) TRDV allele table'; (4) 'Mouse (Mus musculus) germline TRDD genes and alleles'; (5) 'Mouse (Mus musculus) germline TRDJ genes'; (6) 'Mouse (Mus musculus) TRDJ allele table', and (7) 'Correspondence between the different mouse (Mus musculus) TRDV gene nomenclatures'. These tables are available at the IMGT Marie-Paule page from IMGT, the international ImMunoGeneTics database (http://imgt.cines. fr:8104) created by Marie-Paule Lefranc, Université Montpellier II, CNRS, Montpellier, France.
Assuntos
Genes/imunologia , Receptores de Antígenos de Linfócitos T gama-delta/genética , Alelos , Animais , Camundongos , Camundongos Endogâmicos A , Camundongos Endogâmicos BALB C , Camundongos Endogâmicos C57BL , Camundongos Endogâmicos DBA , Terminologia como AssuntoRESUMO
'Protein Displays of the Human T Cell Receptor Alpha, Beta, Gamma and Delta Variable and Joining Regions', the 13th report of the 'IMGT Locus in Focus' section, comprises 8 figures: (1) 'Protein display of the human TRA V-REGIONs'; (2) 'Protein display of the human TRB V-REGIONs'; (3) 'Protein display of the human TRG V-REGIONs'; (4) 'Protein display of the human TRD V-REGIONs'; (5) 'Protein display of the human TRA J-REGIONs'; (6) 'Protein display of the human TRB J- REGIONs'; (7) 'Protein display of the human TRG J-REGIONs'; (8) 'Protein display of the human TRD J-REGIONs', and 4 tables entitled: (1) 'FR-IMGT and CDR-IMGT length of the human TRAV genes'; (2) 'FR-IMGT and CDR-IMGT length of the human TRBV genes'; (3) 'FR-IMGT and CDR-IMGT length of the human TRGV genes'; (4) 'FR-IMGT and CDR-IMGT length of the human TRDV genes'. These figures and tables are available at the IMGT Marie-Paule page from IMGT, the international ImMunoGeneTics database (http:// imgt.cines.fr:8104) created by Marie-Paule Lefranc, Université Montpellier II, CNRS, Montpellier, France.
Assuntos
Perfilação da Expressão Gênica , Receptores de Antígenos de Linfócitos T alfa-beta/química , Receptores de Antígenos de Linfócitos T gama-delta/química , Sequência de Aminoácidos , Bases de Dados Factuais , Humanos , Dados de Sequência Molecular , Receptores de Antígenos de Linfócitos T alfa-beta/genética , Receptores de Antígenos de Linfócitos T gama-delta/genéticaRESUMO
The 'Human Immunoglobulin Heavy Diversity (IGHD) and Joining (IGHJ) segments', fifth report of the 'IMGT Locus on Focus' section, comprises six tables entitled: (1) 'Human germline IGHD segments at 14q32.33'; (2) 'Human IGHD alleles'; (3) 'Human germline IGHJ segments at 14q32.33'; (4) 'Human IGHJ alleles'; (5) 'Human germline IGHD orphons on chromosome 15 (15q11.2)'; (6) 'Correspondence between the different human IGHD nomenclatures', and two figures: (1) 'Protein display of human IGH D-REGIONs'; (2) 'Protein display of human IGH J-REGIONs'. These tables and figures are available at the IMGT Marie-Paule page from IMGT, the international ImMunoGeneTics database (http://imgt.cnusc.fr:8104) created by Marie-Paule Lefranc, Université Montpellier II, CNRS, France.
Assuntos
Cadeias Pesadas de Imunoglobulinas/genética , Cadeias J de Imunoglobulina/genética , Alelos , Sequência de Aminoácidos , Sequência de Bases , Cromossomos Humanos Par 15/genética , Humanos , Cadeias Pesadas de Imunoglobulinas/classificação , Cadeias J de Imunoglobulina/classificação , Dados de Sequência MolecularRESUMO
'Human Immunoglobulin Heavy Variable Genes', the fourth report of the 'IMGT Locus on Focus' section, comprises five tables entitled: (1) 'Number of human germline IGHV genes at 14q32.33 and potential repertoire'; (2) 'Human germline IGHV genes at 14q32.33'; (3) 'Human IGHV orphons on chromosome 15 (15q11.2)'; (4) 'Human IGHV orphons on chromosome 16 (16p11.2)', and (5) 'Human IGHV allele table'. These tables are available at the IMGT Marie-Paule page from IMGT, the international ImMunoGeneTics database (http://imgt.cnusc.fr:8104) created by Marie-Paule Lefranc, Université Montpellier II, CNRS, France.
Assuntos
Genes de Imunoglobulinas/genética , Cadeias Pesadas de Imunoglobulinas/genética , Região Variável de Imunoglobulina/genética , Bases de Dados Factuais , Humanos , Internet , Terminologia como AssuntoRESUMO
We studied tissue transglutaminase (TGase) expression in human myelomonocytic leukemia cells treated by combinations of all-trans retinoic acid (RA) and 1,25 dihydroxyvitamin D3 (VD). We found that in U937 cells, as in HL-60 and THP-1 cells, RA alone caused an early induction of enzyme activity, correlated with increased mRNA expression. VD alone also induced rapid TGase mRNA expression but in this case TGase enzymatic activity was not measurable until 96 h following onset of treatment. Combinations of both agents had no additional effects over those of RA alone on HL-60 cells, THP-1, and U937 cells during the first 48 h. However, following further incubation, U937 cells expressed increased levels of TGase when treated by both agents. By many criteria, including their sensitivity to various inducers of oxidative burst, lipopolysaccharide-induced production of monokines and in the present work, lysozyme secretion and TGase expression, U937 cells exposed to combinations of RA and VD exhibit a behavior different from those of HL-60 and THP-1 cells. They represent a type of leukemia cell amenable by this treatment to a stage close to that of a terminally differentiated macrophage.
