RESUMO
Cutaneous involvement is often an initial presentation of infection with Fusarium species, which occurs more commonly in immunocompromised hosts and may be either localized or widespread. Skin lesions typically appear as red or grey macules, which may develop central ulceration and black eschar. Secondary dissemination to extracutaneous organs may occur in immunocompromised hosts, especially those with prolonged and severe neutropenia. We describe a case of widespread cutaneous involvement after infection with Fusarium solani in childhood acute lymphoblastic leukaemia that responded successfully to treatment with prolonged liposomal amphotericin B.
Assuntos
Dermatomicoses/complicações , Fusarium/isolamento & purificação , Infecções Oportunistas/complicações , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações , Pré-Escolar , Dermatomicoses/imunologia , Feminino , Humanos , Hospedeiro Imunocomprometido , Infecções Oportunistas/imunologia , Leucemia-Linfoma Linfoblástico de Células Precursoras/imunologiaRESUMO
We report a 33-year-old woman with haemodialysis-associated pseudoporphyria successfully responding to treatment with oral N-acetylcysteine. We briefly review the current literature on bullous skin disorders in end-stage renal disease, and compare and contrast the pathogenesis of pseudoporphyria and porphyria cutanea tarda in this context. We also discuss the antioxidant properties and clinical applications of N-acetylcysteine, including the treatment of haemodialysis-associated pseudoporphyria.