1.
Health Soc Serv J
; 91(4768): 1268-9, 1981 Oct 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10253416
2.
Lancet
; 2(8194): 594, 1980 Sep 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6106772
3.
Br J Clin Pharmacol
; 9(4): 395-7, 1980 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7378256
RESUMO
1 Acebutolol or diacetolol were added to fresh human plasma in varying concentrations and their extent of binding at 25 degrees C measureed by an equilibrium dialysis technique. 2 The extent of binding for both compounds was shown to be very low, being 11-19% for acebutolol and 6-9% for diacetolol. 3 Partition coefficients were measured in an n- octanol/phosphate buffer (0.05M, pH 7.4) solvent system. For a cebutolol, P = 0.62 and for diacetol, P = 0.08. 4 The very low plasma binding is in accord with the hydrophilic partition coefficients of these compounds.
Assuntos
Acebutolol/análogos & derivados , Acebutolol/sangue , Proteínas Sanguíneas/metabolismo , Humanos , Técnicas In Vitro , Ligação Proteica , Solubilidade
4.
Biochem Soc Trans
; 6(5): 1048-50, 1978.
Artigo
em Inglês
| MEDLINE
| ID: mdl-744319
5.
Nature
; 265(5594): 545-7, 1977 Feb 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-64936