RESUMO
This study demonstrates that significant reproducibility problems can occur during routine use of the Abbott Laboratories LCx assay for Chlamydia trachomatis and Neisseria gonorrhoeae. These problems can go undetected by the quality control procedures outlined in the manufacturer's package insert. We outline here procedures for detecting and preventing contamination and reproducibility problems.
Assuntos
Infecções por Chlamydia/diagnóstico , Chlamydia trachomatis/isolamento & purificação , Gonorreia/diagnóstico , Técnicas de Amplificação de Ácido Nucleico , Kit de Reagentes para Diagnóstico , Humanos , Reprodutibilidade dos TestesRESUMO
Variables of haemostatis were studied in 21 men, aged less than 50 years, with confirmed coronary artery disease but without severe hyperlipidaemia and in 21 healthy controls. Fibrinogen concentrations were significantly raised in the patients, 10 (48%) of whom also showed defective fibrinolysis in response to a standard stress test. These findings suggest that hypercoagulability may be important in the aetiology of some cases of early onset coronary artery disease.
Assuntos
Fatores de Coagulação Sanguínea/análise , Doença das Coronárias/sangue , Adulto , Angina Pectoris/tratamento farmacológico , Transtornos da Coagulação Sanguínea/complicações , Doença das Coronárias/etiologia , Fibrinogênio/análise , Fibrinólise , Humanos , Lipídeos/sangue , Masculino , Pessoa de Meia-Idade , Ativadores de Plasminogênio/sangue , RiscoRESUMO
Retrospective studies in man and prospective studies in animals have indicated that systemically administered anti-inflammatory drugs may decrease plaque-induced inflammation and loss of attachment. The purpose of the present double blind study was to determine the effects of a systemically administered nonsteroidal anti-inflammatory drug and a topically applied steroidal anti-inflammatory drug on experimentally produced gingivitis. Eighteen dental students were brought to a state of optimal gingival health and then divided into three groups. One group received placebo gel to apply topically and placebo capsules. A second group received placebo gel and capsules containing sulindac, a nonsteroidal anti-inflammatory drug. The third group received a topical steroidal gel and placebo capsules. All subjects refrained from home care for 22 days in the maxillary right quadrant. Results of the study indicate that the topical steroidal drug significantly inhibited gingival inflammation while the systemically administered nonsteroidal drug had no apparent effect.
