Sleep quality and falls in middle-aged and older adults: ELSI-Brazil study.

OBJECTIVE: To verify the association between low self-reported sleep quality (LSQ) and fall in middle-aged and older adults every half-decade of life. METHOD: A cross-sectional study was conducted using data from the first wave (2015-2016) of the Brazilian Longitudinal Study of Aging (ELSI-Brazil), which is nationally representative. The sample consisted of 8,950 participants who were allocated into eight age groups: 50-54, 55-59, 60-64, 65-69, 70-74, 75-79, 80-84, and ≥ 85 years. The questionnaires used included self-reported sleep quality and the International Physical Activity Questionnaire short version. Fisher's exact test followed by binary logistic regression analysis was performed to identify the odds ratio of sleep quality for fall occurrence, controlled for confounding variables. RESULTS: Individuals aged 50-105 years (63.6 ± 10.2 years), 57.0% females and 43.0% males, participated in this study. Overall, 21.5% of participants experienced at least one fall. The relative frequency of participants classified as having high or LSQ remained constant across each half-decade of life. The LSQ exhibited a statistically significant OR (p < 0.05) for falls across age groups up to 84, even after accounting for confounding variables. CONCLUSION: LSQ is significantly associated with an increased occurrence of fall in adults aged >50 years, but not for ≥ 85 years regardless of sex and physical activity level.

Forecasting and validating fat mass ratio models through anthropometric measurements and health-related factors among people with HIV: a cross-sectional investigation.

Background: There is a limited research on predictive models of fat mass ratio (FMR) in people living with human immunodeficiency virus (HIV) (PWH). This study aimed to develop models considering anthropometric and health-related factors to predict and validate FMR in PWH regardless of sex. Methods: One hundred and six Brazilian PWH (46.4±9.8 years) were evaluated for body composition using dual-energy X-ray absorptiometry (DXA), body circumference (BC), and skinfold thicknesses (SKs). FMR predictive models were developed using stepwise linear regression, and their agreement with DXA was assessed using Bland-Altman plots. Cross-validation was performed using the predicted residual error sum of squares (PRESS) method. Results: Six FMR estimation models were developed for PWH, with adjusted R2 ranging from 0.43 to 0.72, standard error of the estimate (SEE) from 0.16% to 0.22%, and 95% confidence interval (CI) from 1.03 to 1.15. Model 6, including thigh SK, waist BC, therapy duration, subscapular SK, education years, and abdominal SK, exhibited the highest determination power (R2 adjusted 0.72, SEE 0.16%, and 95% CI: 1.06-1.15). The agreement between DXA-based FMR and predictive models showed minimal bias (-0.03 to +0.04) and narrower limits of agreement, particularly for the top-performing model (-0.33 to +0.30). Model 6 exhibited a high adjusted Q2PRESS (0.70) and low SPRESS (0.17). Conclusions: Our predictive models advance the study of body composition in PWH by consolidating the use of anthropometry for diagnosing and monitoring lipodystrophy regardless of sex.

Proceso de vestirse y desvestirse de los profesionales de enfermería durante la pandemia de covid-19: estudio transversal / Paramentação e desparamentação de profissionais de enfermagem durante a pandemia por covid-19: estudo transversal / Sequence of dressing and undressing by nursing professionals during the covid-19 pandemic: a cross-sectional study

Introducción: Durante la pandemia del covid-19 se implementaron protocolos de seguridad que contribuyeron a la protección de pacientes y profesionales de enfermería. Objetivo: Evaluar el conocimiento sobre el proceso de vestirse y desvertirse de los profesionales de enfermería que actuaron en la asistencia durante la pandemia de covid-19 y verificar la asociación entre ese conocimiento y las características sociodemográficas y de desempeño de los profesionales de enfermería. Método: Estudio transversal, realizado de noviembre de 2020 a diciembre de 2021 con profesionales de enfermería que actúan en el cuidado en las cinco regiones de Brasil. El cuestionario fue desarrollado considerando la Nota Técnica GVIMS/GGTES/ANVISA N° 04/2020. Consta de 10 preguntas, que van de 0 a 10 puntos. Se estableció el punto de corte ≥ 75 puntos y < 74 puntos para indicar conocimiento suficiente y conocimiento insuficiente, respectivamente. La recolección de datos se realizó mediante formularios de Google®, utilizando diferentes redes sociales. Resultados: De los 493 profesionales de enfermería, 157 tenían entre 30 y 39 años, 374 eran del sexo femenino y 358 trabajaban como enfermeros. En cuanto al conocimiento sobre el processo de vestirse y desvestirse, 370 tenían conocimiento suficiente y 123 conocimiento insuficiente. No hubo asociación entre el conocimiento sobre el proceso de vestirse y quitarse con características sociodemográficas y desempeño profesional. Conclusión: Los profesionales de enfermería demostraron conocimientos adecuados sobre el proceso de vestirse y desvestirse y no hubo asociación entre conocimiento y caracterización de los participantes (AU)

Introdução: Durante a pandemia por covid-19 foram implementados de protocolos de segurança que contribuiram para a proteção de pacientes e profissionais de enfermagem. Objetivo: Avaliar o conhecimento sobre a sequência da paramentação e desparamentação por profissionais de enfermagem que atuaram na assistência durante a pandemia por covid-19 e verificar a associação entre esse conhecimento e características sociodemográficas e de atuação dos profissionais de enfermagem. Método: Estudo transversal, realizado de novembro de 2020 a dezembro de 2021 com profissionais de enfermagem atuantes na assistência nas cinco regiões do Brasil. O questionário foi desenvolvido considerando a Nota Técnica GVIMS/GGTES/ANVISA Nº 04/2020. E conta com 10 questões, variando de 0 a 10 pontos. Foi estabelecido o ponto de corte ≥ 75 pontos e < 74 pontos para indicar conhecimento suficiente e conhecimento insuficiente, respectivamente. A coleta de dados foi realizada pelo Google forms®, utilizando diferentes redes sociais. Resultados: Dos 493 profissionais de enfermagem, 157 tinham idade entre 30 a 39 anos, 374 eram do sexo feminino, e 358 atuavam como enfermeiros. Em termos de conhecimento sobre a sequência de paramentação e desparamentação, 370 apresentaram conhecimento suficiente e 123 conhecimento insuficiente. Não teve associação entre o conhecimento sobre paramentação e desparamentação com as características sociodemográficas e de atuação dos profissionais. Conclusão: Os profissionais de enfermagem demonstraram conhecimento adequado sobre a paramentação e desparamentação e não houve associação entre o conhecimento e a caracterização dos participantes. (AU)

Introduction: During the covid-19 pandemic, safety protocols were implemented that contributed to the protection of patients and nursing professionals. Objective: To evaluate the knowledge about the sequence of dressing and undressing by nursing professionals who worked in assistance during the covid-19 pandemic and to verify the association between this knowledge and sociodemographic and performance characteristics of nursing professionals. Method: Cross-sectional study, carried out from November 2020 to December 2021 with nursing professionals working in care in the five regions of Brazil. The questionnaire was developed considering the Technical Note GVIMS/GGTES/ANVISA No. 04/2020. It has 10 questions, ranging from 0 to 10 points. The cutoff point ≥ 75 points and < 74 points was established to indicate sufficient knowledge and insufficient knowledge. Data collection was performed using Google forms®, using different social networks. Results: Of the 493 nursing professionals, 157 were aged between 30 and 39 years, 374 were female, and 358 worked as nurses. In terms of knowledge about the dressing and undressing sequence, 370 had sufficient knowledge and 123 had insufficient knowledge. There was no association between knowledge about dressing and undressing with sociodemographic characteristics and professional performance. Conclusion: Nursing professionals demonstrated adequate knowledge about dressing and undressing and there was no association between knowledge and characterization of the participants. (AU)

Instruments to assess adherence to medication in people living with HIV: a scoping review.

OBJECTIVE: To compile the instruments validated in Brazil for assessing adherence of people living with HIV to antiretroviral therapy. METHODS: Scoping review using the Web of Science, Scopus, Medline (via PubMed), Embase, BDENF, CINAHL and Lilacs databases. In addition, the Preprints bioRxiv, Google Scholar and OpenGrey servers were checked. There was no language restriction for the search, and it considered articles published from the year 1996 onwards. RESULTS: Three publications were included in the qualitative synthesis. Following were the instruments identified "Questionário para Avaliação da Adesão ao Tratamento Antirretroviral" (Questionnaire for Assessment of Adherence to Antiretroviral Treatment) developed in Porto Alegre (RS) and published in 2007; the "Escala de autoeficácia para adesão ao tratamento antirretroviral em crianças e adolescentes com HIV/Aids" (Self-efficacy Scale for Adherence to Antiretroviral Treatment in Children and Adolescents with HIV/Aids) developed in São Paulo (SP) and published in 2008; and the "WebAd-Q, um instrumento de autorrelato para monitorar a adesão à terapia antirretroviral em serviços de HIV/Aids no Brasil" (WebAd-Q, a self-report instrument to monitor adherence to antiretroviral therapy in HIV/Aids services in Brazil) developed in São Bernardo do Campo (SP) and published in 2018. The instruments were validated in Brazil, and presented statistically acceptable values for psychometric qualities. CONCLUSION: The instruments to assess adherence of people living with HIV to antiretroviral therapy are validated strategies for the Brazilian context. However, their (re)use in different settings and contexts of the nation should be expanded. The use of these instruments by health professionals can improve the understanding of factors that act negatively and positively on antiretroviral therapy adherence, and the proposition of strategies intended to consolidate good adherence and intervene in the treatment of people with low therapeutic engagement.

Prevalência de transtorno de ansiedade e fatores associados em crianças durante a pandemia da covid-19: um estudo transversal / Prevalence of anxiety disorder and associated factors in children during the covid-19 pandemic: a cross-sectional study / Prevalencia del trastorno de ansiedad y factores asociados en niños durante la pandemia da covid-19: un estudio transversal

O objetivo do estudo foi verificar a prevalência do transtorno de ansiedade e fatores sociodemográficos, comportamentais e aspectos de saúde associados em crianças de três a 10 anos de idade, durante a pandemia da COVID-19. Estudo de delineamento transversal, realizado na região do Triângulo Mineiro, estado de Minas Gerais, Brasil. Utilizou-se a Escala Spence de Ansiedade Infantil, versão para os pais, para avaliar os sintomas das principais perturbações de ansiedade em crianças. Para comparar proporções utilizou-se o teste Qui-quadrado, os fatores associados ao transtorno de ansiedade foram encontrados por Regressão de Poisson, com intervalo de confiança de 95%. Participaram n=778 pais de crianças de três a 10 anos de idade. A prevalência do transtorno de ansiedade nas crianças foi de 1,7%. Crianças de pais analfabetos e com ensino fundamental II incompleto apresentaram razão de prevalência (RP) = 4,24 [(IC95%: 1,03 ­ 17,46), p=0,045] maior de transtorno de ansiedade que às crianças de pais com nível superior completo a pós-graduação, enquanto as crianças de pais com ensino fundamental a superior incompleto apresentaram uma RP = 2,64 [(IC95%: 0,72 ­ 9,72), p=0,045] em comparação às crianças de pais com nível superior completo a pós- graduação. Crianças com alterações nos padrões alimentares apresentaram uma RP = 11,10 [(IC95%: 1,59 ­ 77,42), p = 0,015] maior de transtorno de ansiedade, em relação às crianças que não possuíam alterações nos padrões alimentares. Concluiu-se que as variáveis que associaram ao transtorno de ansiedade foram o nível de escolaridade dos pais e alterações dos padrões alimentares das crianças.

The objective of the study was to verify the prevalence of anxiety disorder and sociodemographic, behavioral factors and associated health aspects in 3-10-year-old children, during the COVID-19 pandemic. Cross-sectional study carried out in the Triângulo Mineiro, region of Minas Gerais state, Brazil. The Spence Child Anxiety Scale, version for parents, was used to assess the symptoms of the anxiety disorders in children. The Chi-square test was used to compare proportions, the factors associated with the anxiety disorder were found by Regression Poisson, with a 95% confidence interval. Participated in this study 778 parents of 3-10-year-old children. The prevalence of anxiety disorder in children was 1.7%. Children of illiterate parents and with incomplete primary education had a prevalence ratio (PR) = 4.24 [(IC95%:1.03 ­ 17.46), p=0.045] higher for anxiety disorder than children of parents with complete higher education to graduate school, while children of parents with incomplete primary or higher education had a PR = 2.64 [(IC95%:0.72 ­ 9.72), p=0.045] compared to children of parents with a complete higher education at postgraduate level. Children with changes in eating patterns had a PR = 11.10 [(IC95%:1.59 ­ 77.42), p = 0.015] higher for anxiety disorder, compared to children who did not have changes in eating patterns. The study concluded that the variables associated with anxiety disorder were parents' education level and changes in children's eating patterns.

El objetivo del estudio fue verificar la prevalencia del trastorno de ansiedad y los factores sociodemográficos, conductuales y de salud asociados en niños de 3 a 10 años, durante la pandemia de COVID-19. Estudio transversal realizado en el Triângulo Mineiro, región del estado de Minas Gerais, Brasil. Se utilizó la Escala de Ansiedad Infantil de Spence, versión para padres, para evaluar los síntomas de los trastornos de ansiedad en los niños. Para la comparación de proporciones se utilizó la prueba de Chi- cuadrado, los factores asociados al trastorno de ansiedad fueron encontrados por Regresión de Poisson, con un intervalo de confianza del 95%. Participaron en este estudio 778 padres de niños de 3 a 10 años. La prevalencia del trastorno de ansiedad en niños fue del 1,7%. Los hijos de padres analfabetos y con educación primaria incompleta tuvieron una razón de prevalencia (RP) = 4,24 [(IC95%:1,03 ­ 17,46), p=0,045] mayor para el trastorno de ansiedad que los hijos de padres con educación superior completa a posgrado, mientras que los niños de padres con estudios primarios o superiores incompletos tuvo un PR = 2,64 [(IC95%:0,72 ­ 9,72), p=0,045] en comparación con los hijos de padres con estudios superiores completos a nivel de posgrado. Los niños con cambios en los patrones alimentarios tuvieron un PR = 11,10 [(IC95%:1,59 ­ 77,42), p = 0,015] mayor para el trastorno de ansiedad, en comparación con los niños que no tuvieron cambios en los patrones alimentarios. El estudio concluyó que las variables asociadas con el trastorno de ansiedad fueron el nivel educativo de los padres y los cambios en los patrones alimentarios de los niños.

Being Physically Active Leads to Better Recovery Prognosis for People Diagnosed with COVID-19: A Cross-Sectional Study.

The regular practice of physical activity helps in the prevention and control of several non-communicable diseases. However, evidence on the role of physical activity in mitigating worsening clinical outcomes in people with COVID-19 is still unclear. The aim of this study was to verify whether different levels of physical activity provide protection for clinical outcomes caused by SARS-CoV-2 infection. A cross-sectional study was conducted with 509 adults (43.8 ± 15.71 years; 61.1% female) with a positive diagnosis of COVID-19 residing in Ribeirão Preto, São Paulo, Brazil. Participants were interviewed by telephone to determine the severity of the infection and the physical activity performed. Binary logistic regression was used to indicate the odds ratio (OR) of active people reporting less harmful clinical outcomes from COVID-19. Active people had a lower chance of hospitalization, fewer hospitalization days, less respiratory difficulty and needed less oxygen support. The results suggest that active people, compared to sedentary people, have a lower frequency of hospitalization, length of stay, breathing difficulty and need for oxygen support. These results corroborate the importance of public policies to promote the practice of physical activity, in order to mitigate the severity of the clinical outcomes of COVID-19.

Instruments to assess adherence to medication in people living with HIV: a scoping review / Instrumentos para avaliar a adesão medicamentosa em pessoas vivendo com HIV: uma revisão de escopo

ABSTRACT OBJECTIVE To compile the instruments validated in Brazil for assessing adherence of people living with HIV to antiretroviral therapy. METHODS Scoping review using the Web of Science, Scopus, Medline (via PubMed), Embase, BDENF, CINAHL and Lilacs databases. In addition, the Preprints bioRxiv, Google Scholar and OpenGrey servers were checked. There was no language restriction for the search, and it considered articles published from the year 1996 onwards. RESULTS Three publications were included in the qualitative synthesis. Following were the instruments identified "Questionário para Avaliação da Adesão ao Tratamento Antirretroviral" (Questionnaire for Assessment of Adherence to Antiretroviral Treatment) developed in Porto Alegre (RS) and published in 2007; the "Escala de autoeficácia para adesão ao tratamento antirretroviral em crianças e adolescentes com HIV/Aids" (Self-efficacy Scale for Adherence to Antiretroviral Treatment in Children and Adolescents with HIV/Aids) developed in São Paulo (SP) and published in 2008; and the "WebAd-Q, um instrumento de autorrelato para monitorar a adesão à terapia antirretroviral em serviços de HIV/Aids no Brasil" (WebAd-Q, a self-report instrument to monitor adherence to antiretroviral therapy in HIV/Aids services in Brazil) developed in São Bernardo do Campo (SP) and published in 2018. The instruments were validated in Brazil, and presented statistically acceptable values for psychometric qualities. CONCLUSION The instruments to assess adherence of people living with HIV to antiretroviral therapy are validated strategies for the Brazilian context. However, their (re)use in different settings and contexts of the nation should be expanded. The use of these instruments by health professionals can improve the understanding of factors that act negatively and positively on antiretroviral therapy adherence, and the proposition of strategies intended to consolidate good adherence and intervene in the treatment of people with low therapeutic engagement.

RESUMO OBJETIVO Compilar os instrumentos validados no Brasil para avaliação da adesão de pessoas vivendo com HIV à terapia antirretroviral. MÉTODOS Revisão de escopo, utilizando as bases de dados Web of Science, Scopus, Medline (via PubMed), Embase, BDENF, CINAHL e Lilacs. Em complementação, os servidores Preprints bioRxiv, Google Scholar e OpenGrey foram verificados. Para a busca, não houve restrição de idioma e considerou artigos publicados a partir do ano de 1996. RESULTADOS Três publicações foram incluídas na síntese qualitativa. Os instrumentos identificados foram o "Questionário para Avaliação da Adesão ao Tratamento Antirretroviral", desenvolvido em Porto Alegre (RS) e publicado em 2007; a "Escala de autoeficácia para adesão ao tratamento antirretroviral em crianças e adolescentes com HIV/Aids", desenvolvida em São Paulo (SP) e publicada em 2008; e o "WebAd-Q, um instrumento de autorrelato para monitorar a adesão à terapia antirretroviral em serviços de HIV/Aids no Brasil", desenvolvido em São Bernardo do Campo (SP) e publicado em 2018. Os instrumentos foram validados no Brasil e apresentaram valores estatisticamente aceitáveis para as qualidades psicométricas. CONCLUSÃO Os instrumentos para avaliar a adesão de pessoas vivendo com HIV à terapia antirretroviral são estratégias validadas para o contexto do Brasil. Todavia há que se expandir a (re)utilização em diferentes cenários e contextos da nação. A utilização desses instrumentos por profissionais da saúde pode melhorar a compreensão dos fatores que atuam negativa e positivamente na adesão à terapia antirretroviral, e a proposição de estratégias com o objetivo de consolidar a boa adesão e intervir no tratamento das pessoas com baixo engajamento terapêutico.

Hand hygiene by the nursing team in home care: a cross-sectional study.

OBJECTIVE: to identify whether nursing professionals carry out hand hygiene, how they do it, and what resources are available for this practice during home visits. METHOD: cross-sectional study conducted in a public Home Care service. The World Health Organization instrument was used to observe the hand hygiene technique, the time of performance, and the product used. RESULTS: a total of 940 hand hygiene opportunities taking place in 231 home visits were observed. Overall adherence was 14.4%, with the practice of hand hygiene being higher after contact with the patient (53.7%). Before aseptic procedures, after risk/exposure to body fluids, after contact with the patient's environment, and before contact with the patient, adherence was 0.4%. Regarding the quality of the technique, in none of the 135 practices the recommended steps were followed. As for the structure available in the households, 35 (15.2%) had accessible sinks and none had liquid soap and alcohol-based formulation. CONCLUSION: adherence to hand hygiene by nursing professionals in home care was low, the technique was not performed, and households did not have resources for the practice.

Situações de risco para exposição a material biológico por profissionais de enfermagem que atuam na assistência domiciliar de um município do interior paulista / Risk situations for exposure to biological material by home care nursing professionals of a city in São Paulo state

Introdução: os profissionais de saúde estão expostos à diferentes riscos no ambiente de trabalho, sendo o risco biológico um dos mais investigados, sobretudo, entre a equipe de enfermagem. Porém, pouco se conhece sobre esse risco para os profissionais de enfermagem que atuam em Serviço de Atenção Domiciliar (SAD). Objetivo: identificar as atividades que se constituem em risco de contato com material biológico e ou acidente percutâneo, para os profissionais de enfermagem, que atuam em SAD. Materiais e Métodos: trata-se de um estudo de corte transversal realizado num município do interior paulista. A população do estudo foi constituída por 231 visitas domiciliares realizadas por 15 profissionais de enfermagem que compunham a equipe coordenadora do SAD do referido município e que prestavam assistência direta à pacientes durante as visitas domiciliares. A coleta de dados foi realizada de agosto de 2016 à janeiro de 2017, após aprovação do Comitê de Ética em Pesquisa da Escola de Enfermagem de Ribeirão. Os participantes que concordaram participar do estudo assinaram o Termo de Consentimento Livre e Esclarecido (TCLE). Nesse período foram acompanhadas 231 visitas domiciliares. Os dados foram analisados por meio de estatística descritiva utilizando-se o programa IBM SPSS Statistics versão 25. Resultados: Das 231 visitas domiciliares observadas, 87 (37,6%) tinham três profissionais, os procedimentos mais realizados foram pressão arterial e pulso (221/95,7%), seguidos de curativo (98/42,4%). Quanto à higiene das mãos, somente 11 (4,8%) profissionais realizaram antes e 124 (53,7%) após a visita. Todos os profissionais utilizavam algum tipo de EPI, sendo o jaleco (229/99,1%) e a luva (156/67,5%) os mais frequentes. Nas visitas que ocorreram procedimentos envolvendo material perfurocortante, o escalpe (29/58%) foi o mais utilizado, 35 (70%) das agulhas tinham dispositivos de segurança e o reencape durante os procedimentos ocorreu em (23/46%) visitas observadas. Conclusões: o presente estudo permitiu identificar as situações de risco mais frequentes na prática dos profissionais de enfermagem que atuavam no SAD durante as visitas domiciliares, as quais poderão subsidiar medidas de prevenção de exposição e consequentemente aumentar a segurança no trabalho e para os usuários desse serviço

Introduction: health professionals are exposed to different risks in the workplace, and one of the most investigated, especially among nursing staff, is the biological risk. However, little is known about this risk for nursing professionals who work in the Home Care Service (SAD). Objective: to identify the activities that constitute a risk of contact with biological material and/or percutaneous accident for the nursing professionals who work in the SAD. Materials and Methods: this is a cross-sectional study carried out in a city in São Paulo state. The study population consisted of 231 home visits performed by 15 nursing professionals from SAD coordinating team who provided direct assistance to patients during home visits. Data collection was carried out from August 2016 to January 2017, after approval of the Research Ethics Committee of the Ribeirão Preto College of Nursing. The participants who agreed to participate in the study signed the Informed Consent Form. During this period, 231 home visits were observed. The data were analyzed through descriptive statistics using the IBM SPSS Statistics version 25. Results: Of the 231 home visits observed, 87 (37.6%) had three professionals, the most performed procedures were blood pressure and pulse (221/95.7%), followed by dressing (98/42.4%). Regarding hand hygiene, only 11 (4.8%) professionals performed it before the visit and 124 (53.7%) after the visit. All the professionals used some type of PPE, and the most frequent ones were the lab coat (229/99.1%) and the glove (156/67.5%). In relation to the visits in which sharp materials were used, the safety scalp needle (29/58%) was the most used, 35 (70%) of the needles had safety devices and its recapping during the procedures occurred in (23/46%) of the visits observed. Conclusions: this study identified the most frequent risk situations in the practice of nursing professionals who worked in the SAD, during home visits. These risk situations may subsidize measures of prevention of exposure and consequently increase the safety in the workplace for the users of this service

Fractalkine (C-X3-C motif chemokine ligand 1) as a potential biomarker for depression and anxiety in colorectal cancer patients.

Fractalkine, a unique chemokine of the CX3C subfamily, is involved in the pathogenesis of different types of cancer and also in non-immune mechanisms associated with psychiatric disorders. The aim of the present study was to investigate whether there is a correlation between anxiety, depression and fractalkine serum levels in colorectal cancer (CRC) patients in different stages of antitumor therapy. Four groups of patients undergoing treatment (n=20 per group) were evaluated: Patients with CRC who did not undergo surgical resection of the tumor; patients who underwent resection and who did not start adjuvant therapy; patients undergoing chemotherapy for ~3 months; and patients who had completed adjuvant chemotherapy regimen for ~6 months. The control group was composed of 20 healthy volunteers free of any psychiatric or immune system disease. Depression and anxiety were evaluated using the Hospital Anxiety and Depression Scale (HADS) and serum levels of fractalkine were measured by cytometric bead array. Clinically relevant levels of anxiety and/or depression were observed in all of the CRC patients at the different stages of antitumor therapy. Elevated serum levels of fractalkine were identified in the CRC patients in the pre-surgery (P<0.001) and pre-chemotherapy (P<0.001) groups, but reduced upon chemotherapy (P<0.05). Furthermore, a positive correlation was observed between fractalkine levels and the HADS scores in the CRC patients at different stages of antitumor therapy. These results demonstrate a link between fractalkine, depression and anxiety in CRC patients indicating that this chemokine is involved in the pathophysiology of these comorbidities. An improved understanding of the molecular mechanisms involved in these psychological disorders will allow the design of novel therapeutic strategies to assist in alleviating such symptoms in cancer patients. Therefore, fractalkine may present as a relevant biomarker for depression and anxiety in CRC patients.

Uso de equipamento de proteção individual em um serviço de atenção domiciliar / Use of personal protective equipment in a home care service / Uso de equipos de protección personal en servicio de atención domiciliaria

Trata-se de um estudo transversal conduzido num Serviço de Atenção Domiciliar do interior paulista. Teve como objetivos identificar o uso de Equipamento de Proteção Individual, dispositivos de segurança, descarte de materiais perfurocortantes e fatores que dificultam e/ou facilitam o seu uso por profissionais da equipe de enfermagem. A população foi composta por 45 participantes e todos relataram usar Equipamento de Proteção Individual, sendo que 100% referiram usar luvas e os procedimentos frequentes para o uso foram curativos e administração de medicamentos. Apesar de relatarem que não há dificuldade para utilizar os Equipamentos de Proteção Individual e que se preocupam com sua própria segurança, observou-se que a adesão não foi integral. Assim, são necessários estudos futuros capazes de avaliar como ocorre de fato a assistência à saúde dos usuários nos domicílios, para que estratégias de prevenção possam ser identificadas e incorporadas à prática desses profissionais (AU).

A cross-sectional study was conducted at a home care service in the state of São Paulo. The objective of the study was to identify the use of personal protective equipment, safety devices, the disposal of sharp objects, and other factors that make difficult and/or facilitate such use by professionals of the nursing team. The population was made up of 45 participants who reported using personal protective equipment. They all reported using gloves, frequent procedures that required their use were dressings and administration of medications. Although it was reported that the participants did not have difficulty in using personal protective equipment, and that they were concerned about their own safety, full adherence was lacking. Therefore, further studies that are able to evaluate how home care services really occur are necessary, so that prevention strategies can be identified and incorporated into professionals' practice (AU).

Estudio transversal realizado en un Servicio de Atención Domiciliaria del interior paulista, con el objetivo de identificar el uso de Equipos de Protección Personal, mecanismos de seguridad, descarte de materiales punzocortantes y factores que dificultan y/o facilitan su utilización en profesionales del equipo de enfermería. La población se compuso de 45 participantes, todos informaron usar Equipos de Protección Personal, el 100% afirmó usar guantes y los procedimientos para su uso frecuente fueron vendajes y administración de medicamentos. A pesar de informarse que no existe dificultado para utilizar Equipos de Protección Personal y que se preocupan por la propia seguridad, se observó que la adhesión no fue integral. Consecuentemente, existe necesidad de estudios a futuro, capaces de evaluar cómo transcurre de hecho la atención de la salud de usuarios en sus domicilios, para poder identificar e incorporar estrategias preventivas a la práctica de estos profesionales (AU).