Incidence and prevalence of inflammatory bowel disease in Mexico from a nationwide cohort study in a period of 15 years (2000-2017).

Despite the worldwide increasing incidence and prevalence of Inflammatory Bowel Disease (IBD), our knowledge about it in Mexico is still limited. The aim of this study is to describe the incidence and prevalence of IBD as well as its clinical and socio-demographical characteristics in Mexico from a nation-wide perspective.Multicenter nation-wide cohort study that included 42 IBD clinics from all over the country that participated with electronically register of the new cases over 17 years as well as all known existing cases together with their clinical and socio-demographical characteristics from patients with IBD (ulcerative colitis [UC], Crohn disease [CD], and inflammatory bowel disease unclassified [IBDU]). The data collection was conducted between January and October 2017. Incidence, prevalence, and mean incidence over 2 decades were then calculated. Data base was analyzed using SPSS v24 program SPSS (version 24, IBM Corp., Armonk, NY, USA).A total of 2645 patients with IBD were registered. The crude incidence rates of IBD, UC, and CD, respectively, were 0.21, 0.16, and 0.04 cases per 100,000-person year. The highest incidence was registered in the year 2015, compared with to the previous years. The mean incidence of IBD has increased steadily from 0.05 to 0.21 per 100,000 person-years over the past 15 years (P = .06). The incidence of IBD new cases have increased significantly throughout the last 16 years, 5.9-fold for IBD, 5.3-fold for UC, and 9.5-fold for CD. The prevalence rates of IBD, UC, and CD, respectively, were 1.83, 1.45, and 0.34 cases per 100,000-person-year.This is the first study from a nation-wide perspective that demonstrated a significant increase of prevalence and incidence of IBD in Mexico in the last 15 years.

Using Baclofen to Explore GABA-B Receptor Function in Alcohol Dependence: Insights From Pharmacokinetic and Pharmacodynamic Measures.

Background: The role of GABA-B neurotransmission in addiction has recently received increased attention, with clinical trials indicating that baclofen, a GABA-B receptor agonist, may reduce alcohol consumption, craving and promote abstinence. However, the optimal dose to treat alcohol dependence is unclear with patients requesting and tolerating much higher doses of baclofen, compared with other clinical uses. We assessed the pharmacokinetics and pharmacodynamics (PK/PD) of baclofen to provide insight into GABA-B sensitivity in this patient group, relative to controls. Methods: Male healthy volunteers (controls, n = 12) and abstinent alcohol dependent individuals (AD, n = 8) received single oral doses of baclofen or placebo in a 3-way crossover design. Controls received placebo/10 mg/60 mg baclofen in a randomized, double-blind design, AD received placebo/60 mg/90 mg baclofen in a single-blind design. PK/PD measures were recorded at baseline and multiple time-points up to 6 h post-dosing, including plasma baclofen, plasma growth hormone (GH), Subjective High Assessment Scale (SHAS) and biphasic alcohol effects scale (BAES). Repeated measures ANOVA analysis explored "change from baseline" dose, time, group, and interaction effects, t-tests compared peak effects. Results: Dose-dependent effects of baclofen on PK and PD measures were observed in both control and AD groups. Whilst there were no significant group differences in any baclofen PK parameters (t 1/2, t max , C max , AUC), marked differences in PD effects were clearly evident. In controls, 60 mg baclofen significantly increased total SHAS and BAES scores, and significantly increased plasma GH levels compared with placebo, with peak effects at 60-120 min, in line with its PK profile. In AD, 60 mg baclofen had limited effects on these parameters; SHAS scores, BAES scores and plasma GH levels were significantly blunted compared with controls (significant group*time interactions P = 0.0014, 0.0015 and P < 0.0001, respectively). Conclusions: Our study shows blunted sensitivity to baclofen in AD relative to controls, with no difference in PK suggesting a lower GABA-B receptor sensitivity. This may explain why higher baclofen doses are requested and tolerated in the treatment of alcohol dependence. Our data has implications for choice of dose in future clinical trials in AD and possibly other substances of dependence.

Validated Method for the Quantification of Baclofen in Human Plasma Using Solid-Phase Extraction and Liquid Chromatography-Tandem Mass Spectrometry.

A highly sensitive and fully validated method was developed for the quantification of baclofen in human plasma. After adjusting the pH of the plasma samples using a phosphate buffer solution (pH 4), baclofen was purified using mixed mode (C8/cation exchange) solid-phase extraction (SPE) cartridges. Endogenous water-soluble compounds and lipids were removed from the cartridges before the samples were eluted and concentrated. The samples were analyzed using triple-quadrupole liquid chromatography-tandem mass spectrometry (LC-MS-MS) with triggered dynamic multiple reaction monitoring mode for simultaneous quantification and confirmation. The assay was linear from 25 to 1,000 ng/mL (r(2) > 0.999; n = 6). Intraday (n = 6) and interday (n = 15) imprecisions (% relative standard deviation) were <5%, and the average recovery was 30%. The limit of detection of the method was 5 ng/mL, and the limit of quantification was 25 ng/mL. Plasma samples from healthy male volunteers (n = 9, median age: 22) given two single oral doses of baclofen (10 and 60 mg) on nonconsecutive days were analyzed to demonstrate method applicability.

Susceptibilidad a la fiebre amarilla en el municipio Infante, estado Guárico, Venezuela, 2010 / Susceptibility against yellow fever in Infante municipality, Guarico state,Venezuela, 2010

Con el objetivo de determinar el porcentaje de población susceptible frente a la fiebre amarilla se realizó estudio de campo,observacional, descriptivo, seleccionando muestra aleatoria y estratificada de 500 sujetos por procedimiento para Monitoreo Rápido de Cobertura (MRC), distribuidos por parroquias y sectores con bajas coberturas administrativas de vacunación. La cobertura real del municipio obtenida por MRC fue de 89%, mientras que la administrativa era 114%; estimándose en general, 11% de susceptibles para fiebre amarilla, siendo este porcentaje mayor en niños menores de 1 año (75%) y de un año (44%) de edad. En conclusión, las coberturas vacunales reales son menores a lo establecido en Programa Ampliado de Inmunizaciones (mínimo de 95%), por lo que se recomienda reforzar el trabajo para aumentar la cobertura vacunal.

In order to determine population susceptibility against yellow fever, an observational, and descriptive study was conducted, selecting a stratified random sample of 500 subjects per procedure for Rapid Coverage Monitoring (RCM), distributed by administrative areas with low vaccination coverage. The real coverage of municipality was 89%, while administrative coverage was 114% in general, with estimated 11% of people susceptible to yellow fever, being even higher in children aged one year (44%). In conclusion, real vaccination coverage is less than the provisions of the Expanded Program on Immunization (minimum of 95%), so it is recommended that immunization coverage be increased and reinforced.

Analysis of hair after contamination with blood containing 6-acetylmorphine and blood containing morphine.

The study was carried out to investigate external contamination of hair by blood in heroin-related post-mortem cases. Solutions were prepared containing 0.05, 0.1, 0.2, 0.5 and 3.0µg/mL of 6-monoacetylmorphine (6-AM) only or morphine only in human blood. Samples of approximately 3.2g of drug-free hair were contaminated by soaking in the blood solutions for 5min. They were then removed and left at room temperature. Approximately 0.5g of hair was collected from each of the blood soaked hair samples at 6h, 1, 2, 4 and 7 days after contamination. As each hair sample was collected it was shampoo-washed to prevent further drug absorption. Hair samples were analysed in triplicate using a fully validated method described previously. 6-AM broke down to morphine in all samples. In hair contaminated with blood containing 0.05, 0.1 and 0.2µg/mL 6-AM or morphine drug was either not detected or was detected below the limit of quantitation (0.2ng/mg hair) at all contamination times. In hair contaminated with blood spiked with 0.5µg/mL morphine, the concentration in hair ranged from 0.54 to 0.91ng/mg and in hair contaminated with blood spiked with 3.0µg/mL, from 3.25 to 5.77ng/mg. The concentrations of 6-AM ranged from 0.65 to 1.11ng/mg and morphine from 0.34 to 0.80ng/mg in hair contaminated with 0.5µg/mL 6-AM in blood. 6-AM ranged from 2.12 to 3.67ng/mg and morphine from 0.84 to 2.05ng/mg in hair contaminated with 3µg/mL 6-AM in blood. For 6-AM and morphine ANOVA statistical evaluation showed no significant difference among the concentrations over time.

Distribution of concentrations of cocaine and its metabolites in hair collected postmortem from cases with diverse causes/circumstances of death.

The concentrations and ratios of cocaine, benzoylecgonine (BE), and ecgoninemethylester (EME) in 360 head hair segments and 34 pubic hair samples collected at coroner's postmortem examinations were reviewed. The cases included diverse histories and causes/circumstances of death. The hair was analyzed using a validated method published previously; hair was shampoo washed, solvent washed, followed by extraction using 0.1 M hydrochloric acid and SPE clean-up, and quantitative analysis by gas chromatography-mass spectrometry in selected ion monitoring mode. A statistical evaluation demonstrated that, in head hair, the respective lower, middle, and upper concentration (ng/mg) ranges were < 10 ng total-0.8, > 0.8-18.9, and > 18.9-384.7 cocaine; < 10 ng total-0.6, > 0.6-7.9, and > 7.9-142.2 BE; and < 10 ng total-0.3, > 0.3-0.9, and > 0.9-39.5 EME. In pubic hair, the concentrations (ng/mg) detected were 0.2-236.2 cocaine, < 10 ng total-74.0 BE, and < 10 ng total-3.2 EME. The BE/cocaine ratio range in head hair was 0.01-43.00 (mean 1.39, median 0.28), and in pubic hair it was 0.31-2.67 (mean 0.59, median 0.31). The EME/cocaine ratio in head hair ranged from < 0.01 to 0.46 (mean 0.04, median 0.02), and in pubic hair, it ranged from < 0.01 to 0.32 (mean 0.07, median 0.04). Results reported as < 10 ng total were above the limit of detection and below the limit of quantitation (LOQ) (LOQ = 0.2 ng/mg for 50 mg of hair).

Analysis of hair after contamination with blood containing cocaine and blood containing benzoylecgonine.

In post-mortem work, blood is a potential source of external contamination of hair. The present study was carried out to investigate the amount of drug absorbed into hair which has been contaminated with blood containing either cocaine or BE. Solutions were prepared containing 0.05, 0.1, 0.2, 0.5 and 3.0 microg/mL of either cocaine or BE in human blood. Samples of approximately 3.2g of drug-free hair were contaminated by soaking in the blood solutions for 5 min. They were then removed and left at room temperature. Approximately 0.5 g of hair was collected from each of the blood soaked hair samples at 6h, 1, 2, 4 and 7 days after contamination. As each hair sample was collected it was shampoo-washed to prevent further drug absorption. Hair samples were analysed in triplicate using a fully validated method described previously. EME and cocaethylene were also measured in order to find out if cocaine or BE was breaking down to these compounds. Both cocaine and BE were absorbed into hair in significant concentrations when the concentration in the blood was 0.5 microg/mL or greater; cocaine was more readily absorbed than BE. Cocaine broke down to EME (LOQ) and BE (

Chronic drug use confirmed by hair analysis: its role in understanding both the medical cause of death and the circumstances surrounding the death.

Analysis of hair for drugs is now a well established technique. It is being used increasingly in crime investigation but seldom in routine Coroner's toxicology. Hair analysis is the only method of obtaining a reliable drug history for the weeks or months prior to death. Between 2004 and 2006 from the cases reported to HM Coroner, hair was submitted for analysis in addition to the routine specimens for 286 selected cases. These were all cases where drug use was thought to be involved in the death. The usefulness of the data from hair analysis was evaluated along with the data from the conventional samples. The types of cases were identified where hair analysis provided valuable supporting evidence. It was found that reliable information concerning long-term drug use was important in a wide range of cases including: --demonstrating a history of drug use or lack of it, demonstrating tolerance or lack of it, compliance with medication, death due to long-term cocaine use and its role in depression/suicide, sudden unexplained death, and excited delirium. The cases types are illustrated by reference to individual cases and the implications of the findings discussed. The study demonstrated that hair analysis can provide vital evidence in a wide range of cases reported to HM Coroner. This evidence can be invaluable to the pathologist, Coroner, and the family of the deceased in understanding both the medical cause of death and the circumstances surrounding the death.

Distribution of 6-monoacetylmorphine and morphine in head and pubic hair from heroin-related deaths.

There is limited published data to aid interpretation of analytical findings from hair analysis. The aim of the study was to collate 6-monoacetylmorphine (6-AM) and morphine concentrations in head and pubic hair from heroin users and to propose reference ranges and relate these to the amount of heroin used. The ratio of morphine-to-6-AM was also investigated. A total of 82 head hair samples divided into 173 segments of various lengths and 15 pubic hair samples were collected at postmortem from heroin users. The hair was analysed using a previously published method. A statistical evaluation demonstrated that in head hair, the lower, middle and upper concentration ranges of 6-AM were 0.1-0.9, 0.9-12.5 and 12.5-154.1 ng/mg and those of morphine were 0.1-0.8, 0.8-6.0 and 6.0-36.3 ng/mg. In pubic hair, the lower, middle and upper concentration ranges of 6-AM were 0.2-0.5, 0.5-2.3 and 2.3-18.2 ng/mg and those of morphine were 0.2-0.4, 0.4-2.4 and 2.4-13.3 ng/mg. The morphine-to-6-AM ratio showed a large variation. The ratio tended to decrease from proximal to distal segments. The statistical results suggest low, middle and high concentration ranges which we propose can be used for estimating the amount of heroin consumed into corresponding low or occasional, regular or habitual and heavy or excessive drug use. The ratio of morphine-to-6-AM showed great variation and did not support the proposal that a ratio less than 0.77 is needed to prove ingestion of heroin.

Simultaneous quantification of opiates, amphetamines, cocaine and metabolites and diazepam and metabolite in a single hair sample using GC-MS.

A method is described for the simultaneous identification and quantification of opiates, amphetamines, cocainics, diazepam and nordiazepam from one hair extract (typically 10-50mg hair). After decontamination by washing with shampoo, dichloromethane, isopropanol and acetone, drugs were extracted using 0.1M HCl followed by SPE clean-up using mixed-mode extraction cartridges. The SPE extracts were submitted to a two-step derivatisation using MBTFA and MSTFA+1% TCMS and analysis was performed by GC-MS using both SIM and scan modes. Four deuterated standards were used to monitor 14 compounds. The limit of quantification was the total drug detected from the sample. This was 5 ng for amphetamines and 10 ng for remaining drugs which is equivalent to 0.1 and 0.2 ng/mg from a 50mg sample. Standard curves for the range 5-400 ng total drug concentration for all drugs had regression coefficients greater than 0.98. An authentic hair sample was used to validate the method and gave R.S.D.s <25% for both inter and intra-day reproducibility. The results of the analysis of hair taken from four patients attending a drug treatment clinic and six hair samples including head hair, pubic hair, axial hair and beard taken at post-mortem are presented.

Comparison of the various opiate alkaloid contaminants and their metabolites found in illicit heroin with 6-monoacetyl morphine as indicators of heroin ingestion.

In this study the use of the various opiate alkaloid contaminants as potential markers for illicit heroin ingestion were investigated. Urine samples (n = 227) taken from prisoners for routine drug screen, which were positive for opiates by immunoassay screening, were analyzed for contaminants in illicit heroin. A previously described method was used for the analysis; urines were extracted using mixed-mode solid-phase extraction; the extracts were derivatized using N-methyl-bistrifluoroacetamide and N-methyl-N-trimethylsilyltrifluoroactamide/trimethylchlorosilane. The derivatized extracts were subjected to electron impact gas chromatography-mass spectrometry. The extracts were injected in full scan mode followed by selected ion monitoring mode for target opiate alkaloids found as contaminants in illicit heroin. The opiate alkaloids and their metabolites specifically targeted included meconine, desmethylmeconine, hydrocotarnine, acetylcodeine, codeine, morphine, 6-monacetylmorphine (6-mam), papaverine, hydroxypapaverine, and dihydroxypapaverine. Of the 227 samples positive for opiates by immunoassay, using a cut-off of 300 ng/mL, 199 were confirmed positive for morphine and using a cut-off of 10 ng/mL, 28 were confirmed positive for 6-mam. Using the screening method described in the study, the following numbers of positives were found: 199 for morphine, 103 for codeine, 5 for meconine, 46 for desmethylmeconine, 18 for 6-mam, 136 for hydroxypapaverine, and 139 for dihydroxypapaverine. Acetylcodeine, hydrocotarnine, and papaverine were not detected in any of the samples. The results of this study show that analysis for papaverine metabolites is more sensitive than 6-mam as a way of demonstrating illicit heroin use.

Screening and semi-quantitative analysis of post mortem blood for basic drugs using gas chromatography/ion trap mass spectrometry.

The study presented here shows that GC-MS with ion trap detection can be used for screening post mortem blood. The method described was used to simultaneously screen for unknowns, identify basic drugs present and semi-quantitate 14 drugs commonly encountered in coroner's toxicology (i.e. was used to determine whether the drugs were present in sub-therapeutic, therapeutic or greater than therapeutic amounts). The equipment used included a Varian Saturn 2000 GC-MS operating in full scan mode, a CP-3800 GC, a CP-8400 autosampler and Saturn GC-MS workstation Version 5.5 software. Post mortem blood samples were extracted using a standard liquid-liquid procedure; diethylether followed by back extraction into 0.1 M HCl. Standard curves for the 14 drugs which were semi-quantitated (amitriptyline, citalopram, clozapine, cocaine, cyclizine, diazepam, dihydrocodeine, dothiepin, methadone, mirtazapine, procyclidine, sertraline, tramadol, venlafaxine) were prepared covering the concentration range 0-1.0 ug/mL. The procedure is in routine use for coroners toxicology; semi-quantitation has been used (i) to speed-up the through put of cases where drugs are an incidental finding and (ii) for cases where the amount of sample submitted for analysis was too small to allow for screening, identification and quantitation on separate sample volumes.

Interindividual dose/concentration relationship for methadone in hair.

Hair samples were collected from 60 patients receiving long-term methadone maintenance: 50 were taking the drug orally and 10 were receiving the drug by intravenous injection. The amount of methadone present in the hair samples was measured using methanolic extraction, derivatization of the extracts with MTBSTFA, followed by electron impact gas chromatography-mass spectrometry operating in selected ion monitoring mode. The limit of quantitation for the assay was 0.4 ng/mg hair. The dose/concentration relationship for methadone in hair was investigated. No interindividual correlation between prescribed dose and concentration of methadone in hair was observed.

Esófago en cascanueces segmentario y su relación con reflujo gastroesofágico / Segmentary nutcracker esophagus, its relation with gastroesophageal reflux

El esófago en cascanueces segmentario se define como: contracciones peristálticas de gran amplitud (>180 mm Hg) "segmentarias" (localizadas en un solo registro). Objetivos: establecer la frecuencia de esófago en cascanueces segmentario en pacientes con ERGE en nuestro medio. Materiales y Métodos: Se realizó una revisión retrospectiva, identificando 40 pacientes con cascanueces segmentario de 240 pacientes enviados a nuestros laboratorios por sintomatología de ERGE. Resultados: 25 femeninos y 15 masculinos, edad media de 47.8 años. La manometría encontró una amplitud promedio de las ondas de "cascanueces segmentario" fue de 272.3 mm Hg, el promedio de la presión del EEI fue de 12.05 mm Hg y el promedio del porcentaje de relajación del EEI fue de 112.3 por ciento. Conclusiones: La asociación de enfermedad por reflujo gastroesofágico y el cascanueces segmentario es un hallazgos importante, en nuestra serie representa el 16.6 por ciento de pacientes enviados por reflujo.

La biorretroalimentación como tratamiento para la incontinencia fecal y la constipación / Bioretroalimentation as treatment for fecal incontenence and constipation

La Biorretroalimentación (BRA) se está convirtiendo en el tratamiento de elección de la constipación obstructiva y de la incontinencia fecal. Consiste en reenseñar la función normal de los músculos por medio de registros manométricos y estimulación a través de medios visuales o auditivos. Objetivo: Mostrar la experiencia con la BRA como tratamiento de la incontinencia fecal y la constipación. Material y Métodos: Se revisó retrospectivamente la BRA en 23 pacientes con incontinencia fecal (11), trauma obstétrico (3) y anismo (9) excluyendo causas orgánicas. Resultados: Se obtuvo una efectividad del tratamiento en 65 por ciento de los pacientes con anismo y una efectividad de 70 por ciento en pacientes con incontinencia fecal, logrando la misma efectividad por un periodo de 6 meses. Conclusión: La BRA es un tratamiento accesible y exitoso para los pacientes con incontinencia fecal o constipación. Se logró una efectividad de 65 y 70 por ciento para anismo y constipación, respectivamente.

Morbilidad por síndrome del túnel carpiano en pacientes del Hospital Pastor Oropeza (Seguro Social) / The morbility by carpal tunnel syndrome in patients of the Hospital Pastor Oropeza (Seguro Social)

Se realizó un estudio descriptivo transversal con el objetivo de analizar la morbilidad por Síndrome del Túnel Carpiano en pacientes que acudieron a la consulta de cirugia de mano del Hospital "Pastor Oropeza" del Instituto Venezolano del Seguro Social en el período 1992 - 1996. Se tomaron los datos de los registros del archivo de historias médicas de dicho hospital para lo cual se diseñó una hoja donde se registraron las variables de interés: edad, sexo y ocupación entre otras. Entre los resultados más relevantes se encontró que el 78,7 por ciento de los pacientes pertenecían al sexo femenino, ubicándose la mayoría en el grupo etario entre 40 y 49 años. La ocupación más frecuente fue oficios del hogar (38,3 por ciento). De igual modo se evidenció que el síntoma principal fue el dolor (76,6 por ciento) seguido de parestesias (68,7 por ciento) y limitación funcional (42,5 por ciento) Aquellos pacientes con recurrencia la hicieron en su mayoría (50 por ciento) a los 20-29 meses de la intervención quirúrgica. Se espera con estos resultados, suministrar al Hospital "Pastor Oropeza" estadístcas propias sobre esta patología que puedan ser usadas al elaborar medidas preventivas dirigidas a empresas cuyos obreros realizan trabajos manuales

Prevalencia de tumores osteocartilaginosos diagnosticados mediante biopsias en el Servicio de Anatomía Patológica del Hospital Antonio María Pineda. Período 1987- 1996 / Prevalence of osteocartiloginous tumor diagnosed by biopsy at the pathological anatomy departament of the Hospital Central Universitario Antonio María Pineda

Se realizó una revisión de tipo descriptiva longitudinal retrospectiva con la finalidad de determinar la prevalencia de tumores osteocartilaginosos diagnosticados mediante biosias en el Servicio de Anatomía Patológica del Hospital Central Antonio María Pineda para la cual se seleccionaron 87 pacientes con dicho diagnóstico. Se encontró que los tumores más frecuentes fueron los benignos (68,9 por ciento del total), y entre ellos el osteocondroma representó un 51,6 por ciento, seguido por el osteoma (10 por ciento), la displasia fibrosa (10 por ciento) y el quiste óseo aneurismático (8,3 por ciento). Los tumores malignos representaron un 31,1 por ciento del total y el más frecuente fue el osteosarcoma (81,5 por ciento de los malignos)

Prevalencia de tumores osteocartilaginosos diagnósticados mediante biopsias / Prevalence of osteocartilaginous tumors diagnosed by biopsy

Se realizó una revisión de tipo descriptiva longitudinal retrospectiva con la finalidad de determinar la prevalencia de tumores osteocartilaginosos diagnósticados mediante biopsias en el Servicio de Anatomía Patológica del Hospital Central Universitario "Antonio María Pineda" para la cual se seleccionaron 87 pacientes con dicho diagnóstico. Se encontró que los tumores más frecuentes fueron los benignos (68,9 por ciento del total), y entre ellos el osteocondroma representó un 51,6 por ciento, seguido por el osteoma (10 por ciento) la displasia fibrosa (10 por ciento) y el quiste ósedo aneurismático (8,3 por ciento). Los tumores malignos representaron un 31 por ciento del total y el más frecuente fue el osteosarcoma (81,5 por ciento de los malignos)

Prevalencia de tumores de tejidos blandos diagnosticados mediante biopsias en el Servicio de Anatomía Patológica del Hospital Central "Antonio María Pineda": Barquisimeto, 1987-1996 / Prevalence of tumor of the soft tissues diagnosed by biopsy the Pathological Anatomy Departament of the Hospital Central Universitario \"Antonio María Pineda\": Barquisimeto 1987-1996

Se realizó una revisión de tipo descriptiva longitudinal retrospectiva con la finalidad de determinar la prevalencia de tumores de tejidos blandos diagnosticados mediante biopsias en el Servicio de Anatomía Patológica del Hospital Central Universitario "Antonio María Pineda", para lo cual se seleccionaron 2.122 pacientes con dichos diagnósticos. Se encontró que los tumores más frecuentes fueron benignos (97,88 por ciento del total), y entre ellos el, Leiomioma representó un 59,08 por ciento seguido por el Lipoma (19,02 por ciento del total, y Hemangioma fueron el Leiomiosarcoma (32.55 por ciento) el Rabdomiosarcoma Embrionario (27,90 por ciento) y el Fibrosarcoma (18,60 por ciento)