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INTRODUCTION: In females with congenital adrenal hyperplasia (CAH), the influence of hyperandrogenism and glucocorticoid supplementation on neurocognition is controversial. OBJECTIVES: To identify possible differences in visual working memory and verbal memory in adolescent girls with CAH due to 21-hydroxylase deficiency and matched controls. Moreover, to study if any relationship between variables associated with CAH and the scores of the selected memory tests was present. MATERIAL AND METHODS: In total 39 individuals were studied, female adolescents with CAH and age and pubertal stage matched healthy male and female controls (13 in each group). Sociodemographic, clinical, hormonal, and neurocognitive variables were explored. In female adolescents with CAH, variables related to the disease (age at diagnosis, clinical form, time since diagnosis, and glucocorticoid doses) were correlated with the scores obtained for neurocognitive variables. RESULTS: The mean age was 13.9 ± 3.3 years. In female adolescents with CAH the results were worse compared to controls in Free Recall (p = 0.039) and in Visual Memory Span score (p = 0.016). Age at diagnosis was negatively correlated to number of hits (p = 0.04), number recalled backward (p = 0.03), Visual Memory Span test score (p = 0.04) and Total Free Recall (p = 0.04), i.e., memory was worse with later diagnosis. CONCLUSIONS: Female adolescents with CAH had worse visual working memory compared to matched controls, but not in verbal memory. Age at diagnosis was negatively associated with the memory tests.
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RESUMEN Introducción: Los adolescentes con historia familiar de diabetes mellitus tipo 2 presentan una mayor frecuencia de factores de riesgo cardiometabólico que elevan la probabilidad de desarrollar esta afección. Bajo esta hipótesis, se realizó este estudio. Objetivo: Identificar factores de riesgo cardiometabólico en adolescentes con diabetes mellitus tipo 2, como antecedente familiar. Métodos: Se realizó un estudio descriptivo transversal en adolescentes con estos antecedentes en un consultorio del policlínico Luis A. Turcios Lima. Se exploraron variables clínicas, bioquímicas, de imagen y relacionadas con estilos de vida. Resultados: Se estudiaron 40 adolescentes, el 62,5 por ciento masculino. El 90 por ciento tenía como antecedentes otras enfermedades crónicas no transmisibles en familiares de primer y segundo grados, con predominio de la hipertensión arterial. En relación a los estilos de vida, predominó el sedentarismo en el 45 por ciento. Se detectó 50 por ciento con obesidad abdominal, 25 por ciento con sobrepeso/obesidad, 15 por ciento con acantosis nigricans y 10 por ciento con prehipertensión. El 10 por ciento mostró dislipidemia y el 30 por ciento hígado graso no alcohólico, que se relacionó con la presencia de acantosis (p= 0,002) y circunferencia de cintura elevada (p= 0,024). El índice cintura-talla ≥ 0,50 se asoció con la presencia de acantosis nigricans (p= 0,000), aumento de la ecogenicidad hepática (p= 0,001) e hipertrigliceridemia (p= 0,000). Conclusiones: El sedentarismo, la obesidad central y el hígado graso no alcohólico, así como, la historia familiar de hipertensión arterial se presenta con elevada frecuencia en adolescentes con antecedentes familiares de DM2(AU)
ABSTRACT Introduction: Adolescents with family history of diabetes mellitus type 2 present a higher frequency of cardiometabolic risk factors that increase the likelihood of developing this condition. Under this hypothesis, this study was conducted. Objective: To identify cardiometabolic risk factors in adolescents with diabetes mellitus type 2 as a family background. Methods: A descriptive cross-sectional study was conducted in adolescents with this background in a Family Doctor´s office belonging to ´´Luis A. Turcios Lima´´ Policlinic. Clinical, biochemical, image and related to lifestyle variables were explored. Results: 40 adolescents were studied, 62.5 percent of them were males. The 90 percent had a history of other chronic non-communicable diseases in relatives of first and second degrees, with predominance of arterial hypertension. In relation to the lifestyle, there was a predominance of physical inactivity in the 45 percent. 50 percent was detected with abdominal obesity, 25 percent with overweight/obesity, 15 percent with acanthosis nigricans and 10 percent with pre-hypertension. The 10 percent showed dyslipidemia and the 30 percent had non-alcoholic fatty liver disease, which was related to the presence of acanthosis nigricans (p= 0,002) and high waist circumference (p= 0.024). The waist/height rate ≥ 0.50 was associated with the presence of acanthosis nigricans (p= 0.000), increased echogenicity of the liver (p=0.001) and hypertriglyceridemia (p= 0.000). Conclusions: A sedentary lifestyle, central obesity and non-alcoholic fatty liver disease, as well as family background of hypertension occurs with high frequency in adolescents with family history of diabetes mellitus type 2(AU)
