Serum Kynurenines Correlate With Depressive Symptoms and Disability in Poststroke Patients: A Cross-sectional Study.

BACKGROUND: Poststroke depression (PSD) is related to adverse functional and cognitive prognosis in stroke patients. The participation of kynurenine pathway metabolites in depression has been previously proposed; however, there are few studies on its role in PSD and disability in stroke. OBJECTIVE: To investigate if there is a correlation between serum kynurenines levels with poststroke anxiety and depression symptoms and disability scales. METHODS: A cross-sectional case-control study was conducted in patients with first stroke, of >1 month and <1 year of evolution, with no history of previous psychiatric or neurological disorders; the Hospital Anxiety and Depression Scale (HADS), Montreal Cognitive Assessment (MoCA), functional evaluations (Barthel index, Functional Independence Measure [FIM]) were applied and serum kynurenines (Kyns) were determined. RESULTS: Sixty patients were included; significant depressive symptoms were found in 63% of the cases; a significant and positive correlation was obtained between levels of 3-hydroxykynurenine (3-HK) with HADS-T (r = 0.30, P = .025) and HADS-D (r = 0.28, P = .039). Depressed patients showed significantly higher levels of 3HK (P = .048) and KYNA (P = .0271) than nondepressed patients; the 3HK levels were inversely correlated with functional scales: Barthel index (r = -0.31, P = .02), FIM (r = -0.40, P = .01); in addition, serum 3HK levels were significantly higher in patients with poor sleep quality (P = .0190). CONCLUSIONS: Serum Kyns show correlation with the presence and severity of depressive symptoms and with the disability and sleep quality. Kyns may be a potential marker of depression risk and disability in stroke in future.

Abatement of the antibiotic levofloxacin in a solar photoelectro-Fenton flow plant: Modeling the dissolved organic carbon concentration-time relationship.

The degradation of solutions of the antibiotic levofloxacin (LVN) in sulfate medium at pH 3.0 has been investigated at pre-pilot scale by solar photoelectro-Fenton (SPEF) process. The flow plant included an FM01-LC filter-press cell equipped with a Ti|Pt anode and a three-dimensional-like air-diffusion cathode, connected to a compound parabolic collector as photoreactor and a continuous stirred tank under recirculation batch mode. The effect of volumetric flow rate on H2O2 electrogeneration from O2 reduction was assessed. Then, the influence of initial LVN concentration and Fe2+ concentration as catalyst on dissolved organic carbon (DOC) removal was thoroughly investigated. LVN was gradually mineralized by SPEF process, with faster DOC abatement at 0.50 mM Fe2+, yielding 100% after 360 min at applied cathodic potential of -0.30 V|SHE. The high mineralization current efficiency (MCE) and low specific energy consumption (ECDOC) revealed the extraordinary role of homogeneous hydroxyl radicals and natural UV light, which allowed the degradation of the antibiotic and its by-products with MCE values greater than 100%. Five cyclic by-products, N,N-diethylformamide and three short-chain linear carboxylic acids were detected by GC-MS and HPLC analyses. A parametric model to simulate the DOC decay versus electrolysis time was implemented for the SPEF pre-pilot flow plant, showing good agreement with experimental data.

Programa de Salud: Centro de Salud Villa Rivero / Health Program: Health Center Villa Rivero

Durante los 3 meses de provincia; se realizaron actividades de acuerdo al analisis de la situacion del area, con la finalidad de disminuir la morbi-mortalidad materno-infantil, y prevenir las patologias mediante la APS.

Calidad de vida percibida por los no-videntes (En personas que asisten Al Centro de Rehabilitación y Educación Especial y los que no asisten. Cochabamba Segundo Semestre 2003) / Quality of life perceived by the not-viewers (In people who attend the Disciplinary center and Special Education and those that do not attend. Secondly semestral Cochabamba 2003)

òSegún el presente estudio, el área de calidad de vida mas afectada es el nivel de independencia en los no-videntes de ambos grupos, porque están limitados en la orientación, movilidad y seguridad. El área que tiene un promedio excelente es el espiritualidad/ religión/ creencias personales, porque tienen mucha confianza en Dios y en sí mismos, lo que les ayuda a afrontar la vida de acuerdo a sus limitaciones.òLa calidad de vida percibida por los no-videntes del C.R.E.E. es mas alto que el de los que no asisten a los centros de rehabilitación, según el resultado de la valoración de las áreas tienen una buena calidad de vida; en cambio los entrevistados en la calle tienen una percepción regular de la calidad de vida.òLos centros de rehabilitación viabilizan el logro de la integración y participación de las personas sordas, ciegas en nuestra sociedad, ayudando a mejorar la calidad de vida en igualdad de oportunidades, así como la respectiva orientación a la familia padres y/o tutores.