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Br J Nutr ; 100(4): 707-10, 2008 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-18315889

RESUMO

The biological activities of a protein isolate from lupin (Lupinus albus) were studied in a rabbit model of atherosclerosis. Focal plaque development was induced at both common carotid arteries by perivascular injury. After surgery, animals were fed three different diets for 90 d, all with 1% cholesterol, 15% SFA and 20% protein; the protein source was casein (CAS), lupin proteins (LUP) or 50% CAS+50% LUP (CAS+LUP). Lower cholesterolaemia was detected in the LUP v. the CAS group at 60 and 90 d of treatment (-40·3 and -33·5%, respectively; P<0·05). Cryosection analyses of the carotids indicated a significant reduction in focal lesion progression in the LUP v. the CAS group (-37·4%; P<0·05). In summary, in a rabbit model of atherosclerosis, a protein isolate from L. albus reduced cholesterolaemia and exerted a remarkable protective activity against atherosclerosis progression.


Assuntos
Aterosclerose/tratamento farmacológico , Hiperlipidemias/tratamento farmacológico , Lupinus/química , Proteínas de Plantas/uso terapêutico , Animais , Modelos Animais de Doenças , Coelhos
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