Assuntos
Auxiliares de Audição , Zumbido/terapia , Adulto , Audiometria , Método Duplo-Cego , Feminino , Humanos , MasculinoRESUMO
In our preliminary work we were able to demonstrate habituation by analyzing attention correlates in single-trial sequences of auditory event-related potentials (ERPs). Despite different quantitative studies of instantaneous phase of ERPs in long-term habituation, there have been no former studies in generative process underlying the distribution of instantaneous phase information in the context of long-term habituation and its relation to attentional binding. For this means we used a von Mises model, representing the phase information over a set of single trial responses. Additionally we use a quantitative neurofunctional model to predict the dynamics of the instantaneous phase in single-trial ERP data during the long-term habituation. Measured habituation data is used to cross-validate the model's prediction. We conclude that the described method allows for an assessment of dynamic changes in the course of long-term habituation. The results also reinforce our neurofunctional multiscale model of long-term habituation and show the applicability of the described method for the experimental/clinical neurodiagnostic assessment of attentional binding.
Assuntos
Potenciais Evocados/fisiologia , Habituação Psicofisiológica/fisiologia , Modelos Neurológicos , Modelos Estatísticos , Adulto , Algoritmos , Atenção/fisiologia , Intervalos de Confiança , Sincronização de Fases em Eletroencefalografia , Feminino , Humanos , Masculino , Valor Preditivo dos Testes , Reprodutibilidade dos Testes , Ritmo TetaRESUMO
In recent times, the relevance of an accurate diagnosis of attention-deficit/hyperactivity disorder (ADHD) in adults has been the focus of several studies. No longer considered a pathology exclusive to children and adolescents, and taking into account its social implications, developing enhanced support tools for the current diagnostic procedure becomes a priority. Here we present a method for the objective assessment of ADHD in adults using chirp-evoked, paired auditory late responses (ALRs) combined with a two-dimensional ALR denoising scheme to extract correlates of intracortical inhibition. Our method allows for an effective single-sweep denoising, thus requiring less trials to obtain recognizable physiological features, useful as pointers of cortical impairment. Results allow an optimized diagnosis, reduction of data loss and acquisition time; moreover, they do not account exclusively for critical elements within clinical evaluations, but also allow studying the pathophysiology of the condition by providing objective information regarding impaired cortical functions.
Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/fisiopatologia , Percepção Auditiva/fisiologia , Córtex Cerebral/fisiopatologia , Eletroencefalografia/métodos , Potenciais Evocados Auditivos/fisiologia , Inibição Neural/fisiologia , Estimulação Acústica/métodos , Adulto , Artefatos , Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Processamento de Sinais Assistido por Computador , Adulto JovemRESUMO
Auditory Brainstem Responses (ABRs) are commonly used in clinical practice to determine hearing impairments and hearing thresholds. Although many research groups work on automatic recognition of ABRs - in order to decrease the acquisition times - measures to determine the quality of ABR measurements objectively are still missing. In fact, recently released new standards for electroencephalographic measurements in auditory examinations require an objective measurement quality assessment for neurodiagnostic devices. Thus there is a pressing need for the development and evaluation of such a quality control. In this study, we propose (a) a novel technique for the assessment of the ABR measurement quality and (b) evaluate and compare this technique to two other approaches which have been suggested in literature as required by the new standards.
