Manejo psicológico del paciente sometido a cirugía bariátrica. Consenso Núcleo de Psicólogos de Cirugía de la Obesidad de Chile / Chilean consensus on the psychological management of patients undergoing bariatric surgery

Background Bariatric Surgery is the most effective alternative for weight reduction. However, weight regain is a serious problem. Therefore, pre and post-operative psychological management becomes relevant for these patients. Aim To unify criteria about the psychological management patients undergoing bariatric surgery. Material and Methods A questionnaire about psychological practice in bariatric surgery was sent to 50 national expert psychologists, members of the Chilean Bariatric and Metabolic Society. When no agreement among them was achieved, the Delphi methodology was applied. Scores of 86% or greater were used to reach consensus. Results The specialized clinical assessment is crucial for a good preoperative evaluation and to obtain and adequate compliance after surgery. Psychological interventions evolved towards a preparation process to achieve behavioral changes aiming to maintain good long term weight reduction results. Conclusions The indications and recommendations emanating from this consensus generated a document that establishes minimum criteria and quality care standards, which should reduce mental health risks of bariatric surgery and enhance lifestyle changes.

Altered Expression of Natural Cytotoxicity Receptors and NKG2D on Peripheral Blood NK Cell Subsets in Breast Cancer Patients.

Human natural killer (NK) cells are considered professional cytotoxic cells that are integrated into the effector branch of innate immunity during antiviral and antitumoral responses. The purpose of this study was to examine the peripheral distribution and expression of NK cell activation receptors from the fresh peripheral blood mononuclear cells of 30 breast cancer patients prior to any form of treatment (including surgery, chemotherapy, and radiotherapy), 10 benign breast pathology patients, and 24 control individuals. CD3-CD56dimCD16bright NK cells (CD56dim NK) and CD3-CD56brightCD16dim/- NK cells (CD56bright NK) were identified using flow cytometry. The circulating counts of CD56dim and CD56bright NK cells were not significantly different between the groups evaluated, nor were the counts of other leukocyte subsets between the breast cancer patients and benign breast pathology patients. However, in CD56dim NK cells, NKp44 expression was higher in breast cancer patients (P = .0302), whereas NKp30 (P = .0005), NKp46 (P = .0298), and NKG2D (P = .0005) expression was lower with respect to healthy donors. In CD56bright NK cells, NKp30 (P = .0007), NKp46 (P = .0012), and NKG2D (P = .0069) expression was lower in breast cancer patients compared with control group. Only NKG2D in CD56bright NK cells (P = .0208) and CD56dim NK cells (P = .0439) showed difference between benign breast pathology and breast cancer patients. Collectively, the current study showed phenotypic alterations in activation receptors on CD56dim and CD56bright NK cells, suggesting that breast cancer patients have decreased NK cell cytotoxicity.