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1.
Trop Biomed ; 41(1): 45-51, 2024 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-38852133

RESUMO

Water pollution in developing countries continues to be a major health problem due to various anthropological activities that contribute to the spread of many parasitic diseases, including those caused by helminths. The aim of this study is to explore the ability of ozone and peroxone to disinfect drinking water contaminated samples with Toxocara canis eggs. The oxidants used were ozone and ozone-hydrogen peroxide combination. The treatment of Toxocara canis eggs was carried out in a 50 ml reactor with an operating volume of 10 ml. The pH conditions (5, 7 and 10) were varied for each treatment. The treatment effect was calculated by counting eggs and examining the condition of the larvae larval condition (whole, broken and hatched larvae) using an optical microscope. The experiment was carried out by exposing the eggs for 60 and 120 minutes to ozone and peroxone. The best results were obtained for helminths treated with the ozone/hydrogen peroxide combination at pH 10, with an inactivation of 79.2%. The synergistic effect of ozone combined with hydrogen peroxide allows higher helminth egg inactivation rates, demonstrating that advanced oxidation processes are a real alternative to apply in the inactivation of Toxocara canis eggs. The results obtained in this study show that the ozone and peroxone treatment could be a useful disinfection process to destroy or inactivate Toxocara canis eggs in processes commonly applied in water treatment.


Assuntos
Desinfetantes , Desinfecção , Ozônio , Toxocara canis , Animais , Ozônio/farmacologia , Toxocara canis/efeitos dos fármacos , Desinfecção/métodos , Desinfetantes/farmacologia , Concentração de Íons de Hidrogênio , Peróxido de Hidrogênio/farmacologia , Óvulo/efeitos dos fármacos , Purificação da Água/métodos , Peróxidos/farmacologia , Larva/efeitos dos fármacos , Água Potável/parasitologia
2.
Mater Lett ; 311: 131554, 2022 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-34963705

RESUMO

COVID-19 pandemic created a global shortage of medical protective equipment. Here, we considered ozone (O3) a disinfectant alternative due to its potent oxidative activity against biological macromolecules. The O3 decontamination assays were done using SARS-CoV-2 obtained from patients to produce artificial contamination of N95 masks and biosecurity gowns. The quantification of SARS-CoV-2 was performed before and after exposing the samples to different ozone gas concentrations for times between 5 and 30 min. Viral loads as a function of the O3 exposure time were estimated from the data obtained by the RT-PCR technique. The genetic material of the virus was no longer detected for any tested concentrations after 15 min of O3 exposure, which means a disinfection Concentration-Time above 144 ppm min. Vibrational spectroscopies were used to follow the modifications of the polymeric fibers after the O3 treatment. The results indicate that the N95 masks could be safely reused after decontamination with treatments of 15 min at the established O3 doses for a maximum of 6 cycles.

3.
Cient. dent. (Ed. impr.) ; 17(1): 15-17, ene.-abr. 2020. ilus
Artigo em Espanhol | IBECS | ID: ibc-189753

RESUMO

La terminología hipomineralización incisivo-molar (HIM) fue descrita por primera vez en 2001 para explicar los defectos de desarrollo cualitativos demarcados del esmalte, que afectan a uno o más molares permanentes, con o sin participación de los incisivos per-manentes1. En los últimos años, las investigaciones han dado lugar a informes de lesiones comparables en segundos molares temporales hipomineralizados, sin embargo, se desconoce si la presencia de opacidades demarcadas en los caninos temporales también puede asociarse con el HIM1-3. Da Silva y cols., en 2017, son los únicos autores hasta el momento que relacionan hipomineralizaciones en segundos molares temporales (HSPM) y caninos temporales (HPC)3. La prevalencia de HSPM varía dependiendo de los países entre 2,9% a un 21,8% 3,7.Se puede esperar que las causas de los defectos de hipomineralización en los segundos molares temporales sean las mismas que en los dientes permanentes, si ocurren conco-mitantemente a la calcificación de su corona, la cual comienza alrededor de la decimooctava semana de gestación 4-7. Se presenta el caso de un paciente infantil, de 6 años, que acudió a consulta para revisión odontológica. Tras la exploración, se observó la presencia de anomalías del color y estructura en: todos los segundos molares y caninos temporales, así como en los primeros molares temporales superiores y primer molar temporal inferior izquierdo (Figuras 1-6). La posterior exploración radiográfica mostró hallazgos patológicos localizados en 54, 64, 65, 74, 75, 84, 85 (Figuras 7-9). El tratamiento supone un desafío ya que es frecuente que los dientes afectados presenten afectación pulpar, además de hipersensibilidad y descomposición post*eruptiva. Esta relación podría sugerir como factor predictivo de aparición de HIM, la presencia HSPM y HPC, así podrían implementarse las medidas de prevención y control con intervalos más frecuentes en estos pacientes


No disponible


Assuntos
Humanos , Masculino , Criança , Desmineralização do Dente/diagnóstico por imagem , Desmineralização do Dente/epidemiologia , Descoloração de Dente/etiologia , Desmineralização do Dente/prevenção & controle , Descoloração de Dente/prevenção & controle , Radiografia Panorâmica
4.
Am J Surg ; 213(3): 590-595, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28148456

RESUMO

BACKGROUND: Anastomotic leak (AL) increases costs and cancer recurrence. Studies show decreased AL with side-to-side stapled anastomosis (SSA), but none identify risk factors within SSAs. We hypothesized that stapler characteristics and closure technique of the common enterotomy affect AL rates. METHODS: Retrospective review of bowel SSAs was performed. Data included stapler brand, staple line oversewing, and closure method (handsewn, HC; linear stapler [Barcelona technique], BT; transverse stapler, TX). Primary endpoint was AL. Statistical analysis included Fisher's test and logistic regression. RESULTS: 463 patients were identified, 58.5% BT, 21.2% HC, and 20.3% TX. Covidien staplers comprised 74.9%, Ethicon 18.1%. There were no differences between stapler types (Covidien 5.8%, Ethicon 6.0%). However, AL rates varied by common side closure (BT 3.7% vs. TX 10.6%, p = 0.017), remaining significant on multivariate analysis. CONCLUSION: Closure method of the common side impacts AL rates. Barcelona technique has fewer leaks than transverse stapled closure. Further prospective evaluation is recommended.


Assuntos
Anastomose Cirúrgica/métodos , Fístula Anastomótica/etiologia , Grampeamento Cirúrgico/métodos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Diabetes Mellitus/epidemiologia , Desenho de Equipamento , Feminino , Humanos , Intestinos/cirurgia , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Duração da Cirurgia , Estudos Retrospectivos , Fatores de Risco , Grampeamento Cirúrgico/instrumentação , Adulto Jovem
5.
IEEE Trans Med Imaging ; 25(8): 1037-43, 2006 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-16894996

RESUMO

Reliable noninvasive estimators of global left ventricular (LV) chamber function remain unavailable. We have previously demonstrated a potential relationship between color-Doppler M-mode (CDMM) images and two basic indices of LV function: peak-systolic elastance (Emax) and the time-constant of LV relaxation (tau). Thus, we hypothesized that these two indices could be estimated noninvasively by adequate postprocessing of CDMM recordings. A semiparametric regression (SR) version of support vector machine (SVM) is here proposed for building a blind model, capable of analyzing CDMM images automatically, as well as complementary clinical information. Simultaneous invasive and Doppler tracings were obtained in nine mini-pigs in a high-fidelity experimental setup. The model was developed using a test and validation leave-one-out design. Reasonably acceptable prediction accuracy was obtained for both Emax (intraclass correlation coefficient Ric, = 0.81) and tau (Ric, = 0.61). For the first time, a quantitative, noninvasive estimation of cardiovascular indices is addressed by processing Doppler-echocardiography recordings using a learning-from-samples method.


Assuntos
Inteligência Artificial , Ecocardiografia Doppler em Cores/métodos , Aumento da Imagem/métodos , Interpretação de Imagem Assistida por Computador/métodos , Isquemia Miocárdica/diagnóstico por imagem , Reconhecimento Automatizado de Padrão/métodos , Disfunção Ventricular Esquerda/diagnóstico por imagem , Algoritmos , Animais , Armazenamento e Recuperação da Informação/métodos , Isquemia Miocárdica/complicações , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Volume Sistólico , Suínos , Disfunção Ventricular Esquerda/etiologia
6.
Acta pediatr. esp ; 64(1): 7-10, ene. 2006. ilus, tab
Artigo em Es | IBECS | ID: ibc-043524

RESUMO

La tiña de los pies es menos frecuente en el niño que en el adulto y raramente aparece antes de los 4 años. Para identificar la prevalencia de este tipo de tiñas entre escolares se planificó un estudio en 39 escuelas del distrito que es área de referencia del Hospital del Mar de Barcelona. Se examinaron 2.613 escolares de edades comprendidas entre los 3 y 15 años. Se detectaron 72 casos con cultivo positivo a dermatófitos, 3 padecían conjuntamente afectación ungueal. La prevalencia era del 2,75% y aumentaba con la edad: un 0,86% entre los 3 y 5 años, un 2,08% entre los 10 y 12 años, y un 7,04% entre los 13 y 15 años. Los agentes fueron Trichophyton mentagrophytes (48,6%), J: rubrum (40,27%), Epidermophyton mophyton floccosum(6,94%y) J:t onsurans( 4,16%). De los 72 casos de dermatofitosis, sólo 49 tenían lesiones clínicas evidentes. Sólo 19 de los 49 con manifestacionesc línicas tenían conocimiento de sus lesiones, y 8 habían realizado tratamiento antifúngico de forma irregular unos meses antes. Posibles razones del bajo nivel diagnóstico podrían estar en: a) el bajo interés familiar por las lesiones, al no haber sido verbalizadas, y ser valoradas como triviales; b) la consideración de situación propia de la edad y asociada a la actividad deportiva; c) reducida sintomatología subjetiva; d) falta de práctica exploratoria sistemática de zonas interdigitales de los pies; e) la falta de un correcto diagnóstico diferencial; f) bajo interés de los adolescentes en acudir a visitas pediátricas; y g) autodiagnóstico y automedicación


Tinea pedís is less common in children than in adults and rarely appears before the age of tour years. A cross-sectional study was performed to determine the prevalence of this type of tinea in schoolc hildren in BarcelonaS, pain. A total of 2,613s choocl hildrenw ith the agesf rom 3 to 15, from 39 schools located in the municipal district in the vicinity of the hospital, were examinedto identity the presence of dermatophytogis of the feet. Seventy-two had positive cultures for tínea pedis and dermatophytes, while in three, the nail was involved as well. The overall prevalence was 2.75%, and increased with age, being 0.86% in 3 to 5-year-olds, 2.08% in 10 to 12-year-old and 7.04% in 13 to 15-year-old. The fungi found were Tríchophyton mentagrophytes (48.6%),T rubrum( 40.27%)Epidermophyton floccosum (6.94%) and T. tonsurans(4.16%).Of these 72 children, 49 had interdigital lesions, only 19 of them were aware of their presence and 8 had received antifungal therapy previously, although not consistently. Although the incidence of tinea pedís is low in children, we think that it is underdiagnose. Possible reasons for this could be the limited interest in the lesions on the part of parents, who consider them trivial and do not mention them during physical examinations; the consideration that the condition is characteristic of the age group and is associated with sports and the generalized use of athletic foot wear, the lack of proper foot hygiene after doing sports; the fact that there are few subjective symptoms; the failure on the part of the pediatrician to systematically and carefully examine the interdigital skin of the feet of healthy children; the lack of an accurate differential diagnosis; the reluctance of adolescents to visit the pediatrician; self-diagnosis and self-medication


Assuntos
Masculino , Feminino , Criança , Pré-Escolar , Humanos , Tinha/diagnóstico , Tinha/epidemiologia , Tinha/terapia , Arthrodermataceae/isolamento & purificação , Dermatomicoses/diagnóstico , Dermatomicoses/epidemiologia , Dermatomicoses/terapia , Dermatoses do Pé/diagnóstico , Dermatoses do Pé/epidemiologia , Trichophyton/isolamento & purificação , Arthrodermataceae/imunologia , Arthrodermataceae/patogenicidade , Ceratodermia Palmar e Plantar Difusa/epidemiologia , Ceratodermia Palmar e Plantar/epidemiologia , Higiene/educação , Higiene/normas , Serviços de Saúde Escolar , Dermatoses do Pé/fisiopatologia
7.
Heart ; 91(10): 1311-8, 2005 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-16162624

RESUMO

OBJECTIVE: To determine the effects of angiotensin converting enzyme (ACE) inhibitors in hypertensive patients with aortic valve stenosis (AS). DESIGN: Observational, drug withdrawal, single blinded study, with randomisation of the order of tests. SETTING: Hypertension and asymptomatic AS. PATIENTS AND INTERVENTIONS: 20 patients (aged 73 (9) years, valve area 0.7 (0.3) cm2, left ventricular ejection fraction > or = 45%) were enrolled. Each patient underwent two sets of tests (with and without taking the drug), each of which included clinical evaluation, Doppler echocardiogram, and symptom limited exercise echocardiography. MAIN OUTCOME MEASURES: Functional and haemodynamic variables while taking and not taking ACE inhibitors. RESULTS: Drug intervention induced no change in patients' subjective functional class. While taking ACE inhibitors, patients had a lower systolic blood pressure (140 (18) mm Hg with ACE inhibitors v 159 (12) mm Hg without ACE inhibitors, p = 0.02), a higher mean pressure gradient (34 (15) mm Hg v 28 (18) mm Hg, p = 0.037), and a higher left ventricular stroke work loss (19 (6)% v 14 (10)%, p = 0.009). Other baseline functional and haemodynamic parameters were unmodified. Five patients had an abnormal blood pressure response during one of the exercise tests (two patients while taking the drug and three patients while not taking the drug). When taking ACE inhibitors, patients had a higher stroke volume at peak stress (59 (11) ml v 54 (25) ml, p = 0.046). All other stress variables remained constant. CONCLUSIONS: In AS, the afterload relief caused by ACE inhibitors is blunted by a parallel increase in the pressure gradient. However, ACE inhibitors favourably affect stress haemodynamic function in most hypertensive patients with AS and should not be discontinued.


Assuntos
Inibidores da Enzima Conversora de Angiotensina/uso terapêutico , Estenose da Valva Aórtica/complicações , Hipertensão/tratamento farmacológico , Idoso , Idoso de 80 Anos ou mais , Pressão Sanguínea/fisiologia , Ecocardiografia Doppler , Ecocardiografia sob Estresse , Exercício Físico/fisiologia , Teste de Esforço , Feminino , Humanos , Hipertensão/complicações , Masculino , Pessoa de Meia-Idade , Método Simples-Cego , Síndrome de Abstinência a Substâncias/etiologia , Resultado do Tratamento
8.
Neurología (Barc., Ed. impr.) ; 18(5): 276-279, jun. 2003.
Artigo em Es | IBECS | ID: ibc-25614

RESUMO

Se presentan dos casos de siderosis superficial del sistema nervioso central, idiopático en un caso y secundaria a hemorragia subaracnoidea de origen no identificado en el otro. Los síntomas que caracterizaron el cuadro clínico de ambos fueron el trastorno de la marcha y la hipoacusia. El estudio de resonancia magnética (RM), demostró un halo de hiposeñal que bañaba las superficies cerebrales, cerebelo, tronco del encéfalo y nervios craneales. Los hallazgos fueron más evidentes en la serie de spin echo potenciada en T2.La alta sensibilidad de la RM para la detección de depósitos de hemosiderina permitió el diagnóstico de esta infrecuente enfermedad (AU)


Assuntos
Idoso , Masculino , Feminino , Humanos , Siderose , Tomografia Computadorizada por Raios X , Ferro , Telencéfalo
9.
Neurologia ; 18(5): 276-9, 2003 Jun.
Artigo em Espanhol | MEDLINE | ID: mdl-12768516

RESUMO

We report two cases of superficial siderosis of central nervous system. In one case it was idiopathic and in the other secondary to an unidentified subarachnoid hemorrhage. The symptoms that characterized the clinical picture of both were gait disturbance and hypoacusis. The MRI study showed a superficial rim of hypointensity that covered the cerebellum and brainstem, and extended along the cranial nerves and the brain surface. The findings were clearer in the T2 spin echo series. Due to the high sensitivity for hemosiderin deposits, MRI made it possible to make the final diagnosis of this rare disease.


Assuntos
Encéfalo/diagnóstico por imagem , Siderose/diagnóstico por imagem , Idoso , Encéfalo/metabolismo , Feminino , Humanos , Ferro/metabolismo , Masculino , Siderose/metabolismo , Tomografia Computadorizada por Raios X
10.
Rev Neurol ; 34(8): 709-14, 2002.
Artigo em Espanhol | MEDLINE | ID: mdl-12080488

RESUMO

OBJECTIVE: To characterize clinically patients with cognitive impairment and frontal lobe degeneration at neuroimaging. PATIENTS AND METHODS: Patients diagnosed of dementia or mild neurocognitive impairment by DSM IV criteria and neuropsychological tests with frontal lobe atrophy and hipoperfusion detected by computed tomography and single photon emission computed tomography. RESULTS: 18 patients, 5:1 on behalf of women; mean age at onset, 74 years; hereditary for dementia, 38%; mean duration of illness at first testing, 2 years; the most common initial symptoms, memory loss. At initial examination, psychotic or behavioral impairment was found in 61% and parkinsonism in 38%, the commonest cognitive troubles at this moment was the executive function, language and anterograde memory dysfunctions at the same rate. Frontal lobe atrophy and hypoperfusion was found in 100%, temporal in 88% and parietal in 38%. Electroencephalogram was pathological in 33%. The course of the disease was progressive but with fluctuation in 27%. Frontotemporal dementia clinical criteria in 13 patients, 4 of them clinical criteria of dementia with Lewy bodies too, and clinical criteria of Alzheimer s disease in 5.


Assuntos
Transtornos Cognitivos/patologia , Demência/patologia , Demência/fisiopatologia , Lobo Frontal/patologia , Idoso , Idoso de 80 Anos ou mais , Doença de Alzheimer/patologia , Doença de Alzheimer/fisiopatologia , Transtornos Cognitivos/fisiopatologia , Eletroencefalografia , Feminino , Lobo Frontal/fisiopatologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Tomografia Computadorizada por Raios X
11.
Rev Neurol ; 34(4): 306-9, 2002.
Artigo em Espanhol | MEDLINE | ID: mdl-12022042

RESUMO

OBJECTIVE: Cerebral biopsy is an invasive technique with limited, specific indications in view of the potential risk of complications. PATIENTS AND METHODS: We reviewed a series of 50 cases of biopsies via craniotomy done over a period of 10 years to investigate suspected non tumoural disorders. RESULTS: There was a predominance of space occupying lesions and treatable infections (36%) and of non diagnostic biopsies (40%). There was poor correlation between the initial clinical diagnosis and the histological findings (50 71%). There were no complications. CONCLUSIONS: We conclude that the indications should be better defined and, in view of the satisfactory tolerance of this procedure, the study group should be increased by using other less invasive procedures (stereotaxia).


Assuntos
Neoplasias Encefálicas/diagnóstico , Encéfalo/citologia , Biópsia , Encéfalo/patologia , Neoplasias Encefálicas/epidemiologia , Craniotomia/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
12.
Rev. neurol. (Ed. impr.) ; 34(8): 709-714, 16 abr., 2002.
Artigo em Es | IBECS | ID: ibc-27690

RESUMO

Objetivo. Caracterización clínica de los pacientes con deterioro intelectual y afección frontal según la neuroimagen. Pacientes y métodos. Estudio de 18 pacientes diagnosticados de demencia o trastorno neurocognitivo leve mediante la DSM-IV y pruebas neuropsicológicas, con atrofia e hipoperfusión frontales vistas en la TAC y en la SPECT. Resultados. 18 pacientes (predominio en mujeres, 5:1), con una edad media de 74 años y antecedentes familiares de demencia en el 38 por ciento. El retraso medio hasta la consulta fue de dos años y la queja más precoz fueron los olvidos. En la primera visita, el 61 por ciento de los pacientes tenía alteraciones psicóticas o de personalidad, y el 38 por ciento, parkinsonismo; las funciones cognitivas más frecuentemente afectadas en ese momento fueron la ejecutiva, el lenguaje y la memoria anterógrada en igual porcentaje cada una. Además de atrofia e hipoperfusión frontales en todos los casos, hubo afección temporal en el 88 por ciento y parietal en el 38. El EEG fue lento en el 33 por ciento de los casos. Si bien el curso evolutivo fue progresivo, hubo fluctuaciones en el 27 por ciento de los pacientes. Trece enfermos cumplían los criterios clínicos de demencia frontotemporal; cuatro de ellos, además, los de demencia con cuerpos de Lewy, y los cinco restantes, los de la enfermedad de Alzheimer (AU)


Assuntos
Idoso , Idoso de 80 Anos ou mais , Masculino , Feminino , Humanos , Tomografia Computadorizada por Raios X , Transtornos Cognitivos , Demência , Doença de Alzheimer , Imageamento por Ressonância Magnética , Eletroencefalografia , Lobo Frontal
13.
Rev. neurol. (Ed. impr.) ; 34(4): 306-309, 16 feb., 2002.
Artigo em Es | IBECS | ID: ibc-27396

RESUMO

Objetivo. La biopsia cerebral es una técnica invasiva con indicaciones selectivas y restringidas por el potencial riesgo de complicaciones. Pacientes y métodos. Revisamos una serie de 50 casos de biopsias por craneotomía, reunidos en un intervalo de 10 años tras indicación por sospecha de patología no tumoral. Resultados. Predominan los hallazgos de procesos expansivos e infecciones tratables (36 por ciento) y los de muestras no diagnósticas (40 por ciento). La concordancia entre el diagnóstico clínico (de sospecha o de salida) y el histológico es baja (50-71 por ciento). No se registraron complicaciones. Conclusiones. Deben mejorarse las indicaciones y, dada la buena tolerancia, debería aumentarse la muestra mediante otros procedimientos menos invasivos (estereotaxia) (AU)


Assuntos
Pessoa de Meia-Idade , Adulto , Masculino , Feminino , Humanos , Potenciais Evocados P300 , Biópsia , Clorfeniramina , Craniotomia , Antagonistas dos Receptores Histamínicos H1 , Neoplasias Encefálicas , Telencéfalo
14.
Bol. pediatr ; 40(171): 27-32, 2000. tab, graf
Artigo em Es | IBECS | ID: ibc-3379

RESUMO

Objetivo: Valorar la respuesta a las medidas de control para la eliminación de la exposición en un grupo de niños controlado en nuestro hospital por intoxicación por plomo. Pacientes y métodos: Se estudiaron retrospectivamente veinte pacientes, clasificados en grupos de acuerdo con los criterios de los Centers for Disease Control, a los que bimensualmente se les hacía una valoración bioquímica, clínica, radiológica y psicométrica. Resultados: Edad media 2,3 años (50 por ciento mujeres y 50 por ciento varones). En 16 casos (80 por ciento) la fuente de exposición fue el agua del grifo; en cuatro casos no se pudo determinar. En la clasificación por grados, 9 (45 por ciento) estaban en el grado IV, 7 (35 por ciento) en el grado III y 4 (20 por ciento) en el grado II. Plumbemia media detectada, 35 µg/dL, siendo los niveles más altos cuanto menor era la edad del niño. Solamente tres casos precisaron tratamiento quelante; el resto respondió favorablemente a las medidas de control. En 5 casos (25 por ciento) se detectaron alteraciones sugerentes de anemia y déficit de hierro y en 2 casos síntomas compatibles con un cuadro de hiperactividad. Conclusiones: La intoxicación por plomo en niños de corta edad, con niveles en sangre moderadamente elevados, raramente produce síntomas y responde muy bien a las medidas de control para la eliminación de la exposición (AU)


Assuntos
Feminino , Pré-Escolar , Masculino , Humanos , Intoxicação por Chumbo/prevenção & controle , Quelantes/uso terapêutico , Seguimentos , Estudos Retrospectivos , Espanha , Intoxicação por Chumbo/etiologia , Intoxicação por Chumbo/tratamento farmacológico
15.
Bol. pediatr ; 40(171): 33-38, 2000.
Artigo em Es | IBECS | ID: ibc-3380

RESUMO

Objetivo: Valorar la respuesta al tratamiento quelante con ácido dimercaptosuccínico (DMSA) en niños con una intoxicación por plomo de modera a severa y comparar la evolución de uno de ellos con el caso de un niño que no recibió tratamiento. Pacientes y métodos: Se revisaron retrospectivamente los casos de tres niños sometidos a tratamiento quelante con DMSA, de 9, 3 y 1 años de edad. La evolución del caso de un año de edad se comparó con la de otro de siete meses de edad que no recibió tratamiento. Periódicamente, se hacían controles analíticos en sangre y orina para evaluar distintos parámetros (plomo, zinc protoporfirina, ácido gamma amino-levulínico, coproporfirinas, etc.).Resultados: Dos de los pacientes, los más jóvenes, respondieron a la primera tanda de tratamiento, con una reducción del plomo tras el rebote del 28 y el 33 por ciento, mientras que el tercer paciente, con una reducción del 19 por ciento, no respondió. El tratamiento fue muy bien tolerado en los tres casos. A los diez meses, la diferencia entre la disminución de la plumbemia del caso tratado y no tratado era mínima, del 59 y 52 por ciento, respectivamente. Conclusiones: El tratamiento quelante con DMSA en niños con intoxicación por plomo es eficaz y bien tolerado. Al comparar el perfil de las plumbemias al cabo de diez meses entre dos casos de edades similares, uno tratado y otro no tratado, surge la duda en cuanto a la necesidad de iniciar o no el tratamiento de forma inmediata, aunque, naturalmente, al tratarse solamente de dos casos, esta aseveración ha de permanecer en el terreno de las conjeturas (AU)


Assuntos
Feminino , Pré-Escolar , Lactente , Masculino , Criança , Humanos , Quelantes/uso terapêutico , Succímero/uso terapêutico , Intoxicação por Chumbo/tratamento farmacológico , Estudos Retrospectivos , Resultado do Tratamento , Espanha
16.
Allergol Immunopathol (Madr) ; 27(3): 165-7, 1999.
Artigo em Inglês | MEDLINE | ID: mdl-10431102

RESUMO

Patients with severe asthma pose a dilemma to the physician since the treatment they need, namely high doses of oral steroids, has serious side effects, especially among the pediatric population. Deficiency in one or more of the IgG subclasses has been associated with abnormal pulmonary function, as well as with recurrent sinopulmonary infections in adults and children. In the last years attention has been focused on alternative therapies for these patients. One of these alternatives is the treatment with intravenous immunoglobulin (IVIG). We report an 11-year-old boy with severe asthma since the age of two years and multiple hospital admissions due to asthmatic crisis even more frequent and severe, to the point of needing, in the last year, daily treatment with high doses of oral steroids (20 mg). During six months the patient was given high doses of intravenous immunoglobulin. After one month of treatment a clinical and spirometric improvement was apparent allowing to taper down the oral steroids until their complete substitution by inhaled budesonide (1,600 microg/day). The only side effects noted were severe headaches after gammaglobulin infusions which responded well to oral paracetamol. This improvement was sustained throughout the treatment period, but few weeks after the IVIG was suspended the clinical and spirometric parameters started to worsen again.


Assuntos
Asma/complicações , Asma/terapia , Imunoglobulinas Intravenosas/uso terapêutico , Sinusite/complicações , Sinusite/terapia , Criança , Humanos , Imunização Passiva , Masculino , Recidiva
17.
Neurologia ; 14(4): 190-2, 1999 Apr.
Artigo em Espanhol | MEDLINE | ID: mdl-10363495

RESUMO

We report two new cases of symptomatic paroxysmal non-kinesigenic dystonia. The first is a 68-year-old woman with paroxysmal spontaneous dystonic spasms in her right arm lasting 1 minute. They occurred 1-2/day, a few months after a cerebral infarction (left internal capsule and left lenticular nucleus) which occurred 6 years ago. The second is a 30-year-old woman with a 7-year-history of spontaneous dystonic postures (flexion spasms) in her left arm lasting 15 minutes and occurring monthly. In this case an Arnold-Chiari malformation with cervical syringomyelia was discovered.


Assuntos
Distonia/diagnóstico , Cinestesia/fisiologia , Adulto , Idoso , Malformação de Arnold-Chiari/complicações , Malformação de Arnold-Chiari/diagnóstico , Infarto Cerebral/complicações , Infarto Cerebral/patologia , Distonia/etiologia , Feminino , Humanos , Imageamento por Ressonância Magnética , Siringomielia/complicações , Siringomielia/patologia
18.
An Esp Pediatr ; 49(4): 359-63, 1998 Oct.
Artigo em Espanhol | MEDLINE | ID: mdl-9859548

RESUMO

OBJECTIVE: The objective of this study was to know the incidence of adverse drug reactions in a group of children sent to our office by their pediatrician under the suspicion of having suffered a drug reaction. PATIENTS AND METHODS: Ninety-eight children were retrospectively studied. Family background, clinical picture, drugs involved, time elapsing between the onset of symptoms and the date of the study, association to other allergic conditions and diagnostic methods used "in vivo" and "in vitro" were evaluated. RESULTS: Mean age of the patients was 4 years with 53.5% being female and 46.5% male. Positive drug allergy in the family background was found in 22%. The clinical picture showed urticaria and angioedema in 36%, morbiliform eruption in 31%, urticaria in 20%, only angioedema in 9% and other symptoms in 4%. Drugs involved included betalactams (78%), macrolides (17.5%) and others (less than 9%). The mean time elapsed between the onset of symptoms and the date of study was 2 years. There was association to other allergic conditions in 18% (50% in the cases in which the drug allergy was confirmed). RAST to penicillin G and V, amoxicillin and ampicillin was done in 28 cases (betalactams), being negative in all of them. Skin tests were carried out in 21 cases (betalactams), being positive in 19% (66% among the confirmed cases). In all but two cases a controlled provocation test was carried out, being positive only in 8. CONCLUSIONS: 1) The presence of adverse drug reactions is confirmed in only 9% of the cases. 2) Confirmation of the clinical history and the provocation test as the most reliable diagnostic methods currently available. 3) Acceptable sensitivity of the skin tests in the case of betalactams. 4) Null sensitivity of the RAST in the case of betalactams.


Assuntos
Hipersensibilidade a Drogas/diagnóstico , Hipersensibilidade a Drogas/etiologia , Adolescente , Criança , Pré-Escolar , Hipersensibilidade a Drogas/epidemiologia , Feminino , Humanos , Incidência , Masculino , Estudos Retrospectivos , Espanha/epidemiologia
19.
Acta Otorrinolaringol Esp ; 49(2): 168-9, 1998 Mar.
Artigo em Espanhol | MEDLINE | ID: mdl-9650320

RESUMO

Hyponatremia is a relatively common postoperative complication which sometimes has dramatic consequences. A case of severe hyponatremia is reported. Although unrelated with the surgical technique, this complication is potentially life-threatening.


Assuntos
Adenoidectomia/efeitos adversos , Hiponatremia/diagnóstico , Hiponatremia/etiologia , Pré-Escolar , Humanos , Síndrome de Secreção Inadequada de HAD/complicações , Masculino
20.
Neurologia ; 13(2): 90-1, 1998 Feb.
Artigo em Espanhol | MEDLINE | ID: mdl-9578676

RESUMO

We describe a 26 year-old woman with cervical plexopathy with damage of left superficial or cutaneous branches, and left cervical sensory dorsal rami. Picture began acutely and vanished few days later. We ruled out known etiologies like traumatisms, tumours and surgical and anaesthetic complicated procedures, therefore the patient suffered an idiopathic cervical plexopathy. We hypothesize two possibilities for this clinical picture: an autoimmune reaction or a muscular entrapment.


Assuntos
Plexo Cervical/fisiopatologia , Síndromes de Compressão Nervosa/diagnóstico , Síndromes de Compressão Nervosa/fisiopatologia , Doença Aguda , Adulto , Feminino , Humanos
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