CLOSING THE LEAK: KEEPING LATE-DECIDING STUDENTS IN THE PIPELINE TO BIOMEDICAL RESEARCH CAREERS.

With the increased competitiveness of undergraduate, graduate, and professional programs, the continuously accelerating rate of technological innovation and development of new global means of communication, and the evolving face of the local, national, and global job markets, choosing a long-term career has become a challenge for many. More and more students opt to take a gap period in their education, pre- or post-college, for soul searching to determine their future path or for improving their skills and competitiveness for successfully applying to academic institutions. Even though such gap years can lead to more mature and determined students, they often derail the educational path of the individual by leading to loss of interest or to new commitments which hinder going back to school. Engaging students in academic and skills training programs that keep them within the academic environment and provide them with exposure to the benefits of higher education has been shown to increase their persistence, leading to an increased rate of attaining higher-level degrees. A number of United States (US) federal funding agencies, including the National Institutes of Health (NIH), have programs such as the Bridges to Baccalaureate Program (support for easing a student's transition from a 2-year junior or community college to a 4-year baccalaureate-granting institution) and Post-baccalaureate Research Education Program (PREP, support for recent college graduates from underrepresented groups or disadvantaged backgrounds to strengthen their research skills and academic competitiveness for pursuing a doctorate degree in the Biomedical Sciences). At Xavier University of Louisiana (Xavier), we have developed a post-baccalaureate technician program under Project Pathways (the NIH National Institute of General Medical Sciences (NIGMS) Division of Training, Workforce Development, and Diversity (TWD)-funded Building Infrastructure Leading to Diversity (BUILD) Program), that provides research experience and training in soft skills to recent Xavier graduates to increase their preparation and competitiveness for graduate programs. The BUILD Technicians also receive both mentee and mentor training and serve as near-peer mentors to undergraduate students in their labs, increasing their scientific identity and preparing them for their future role as graduate teaching assistants. Here, we report the lessons learned from this program and how its differences from other post-baccalaureate programs, including those under the NIH PREP umbrella, have led to improved outcomes for Xavier graduates gaining admission to graduate programs in the Biomedical Sciences.

Emotional intelligence and interpersonal relations.

In 7 studies, the authors examined the link between emotional intelligence and interpersonal relations. In Studies 1 and 2, the participants with higher scores for emotional intelligence had higher scores for empathic perspective taking and self-monitoring in social situations. In Study 3, the participants with higher scores for emotional intelligence had higher scores for social skills. In Study 4, the participants with higher scores for emotional intelligence displayed more cooperative responses toward partners. In Study 5, the participants with higher scores for emotional intelligence had higher scores for close and affectionate relationships. In Study 6, the participants' scores for marital satisfaction were higher when they rated their marital partners higher for emotional intelligence. In Study 7, the participants anticipated greater satisfaction in relationships with partners described as having emotional intelligence.

Regulated expression of neurofibromin in migrating neural crest cells of avian embryos.

Neurofibromatosis type 1 (NF1) is a common human genetic disease involving various neural crest (NC)-derived cell types, in particular, Schwann cells and melanocytes. The gene responsible for NF1 encodes the protein neurofibromin, which contains a domain with amino acid sequence homology to the ras-guanosine triphosphatase activating protein, suggesting that neurofibromin may play a role in intracellular signaling pathways regulating cellular proliferation or differentiation, or both. To determine whether neurofibromin plays a role in NC cell development, we used antibodies raised against human neurofibromin fusion proteins in western blot and immunocytochemical studies of early avian embryos. These antibodies specifically recognized the 235 kD chicken neurofibromin protein, which was expressed in migrating trunk and cranial NC cells of early embryos (E1.5 to E2), as well as in endothelial and smooth muscle cells of blood vessels and in a subpopulation of non-NC-derived cells in the dermamyotome. At slightly later stages (E3 to E5), neurofibromin immunostaining was observed in various NC derivatives, including dorsal root ganglia and peripheral nerves, as well as non-NC-derived cell types, including heart, skeletal muscle, and kidney. At still later stages (E7 to E9), neurofibromin immunoreactivity was found in almost all tissues in vivo. To determine whether the levels of neurofibromin changed during melanocyte and Schwann cell development, tissue culture experiments were performed. Cultured NC cells were found to express neurofibromin at early time points in culture, but the levels of immunoreactivity decreased as the cells underwent pigmentation. Schwann cells, on the other hand, continued to express neurofibromin in culture. These data suggest, therefore, that neurofibromin may play a role in the development of both NC cells and a variety of non-NC-derived tissues.

Retinal pigment epithelial hyperplasia assuming tumor-like proportions. Report of two cases.

Two patients who had highly elevated pigmented masses associated with a chorioretinal scar were observed clinically for several years. The scar was due to presumed histoplasmosis in one patient and toxoplasmosis in the other. Histopathological examination disclosed choroidal and subretinal masses consisting of hyperplastic retinal pigment epithelium. The difficulty in making the diagnosis of RPE hyperplasia in such instances is discussed.

A personal sketch of Frank Burton Walsh.

The author shares his memories of a 48-year friendship with Frank B. Walsh, known as the Father of American neuro-ophthalmology. Personal anecdotes reveal Walsh as a man of kindness, sensitivity and unusual humor, and they document the origins of such lesser known neuro-ophthalmic terms as "Walsh's sign of mad" and "the belly button nystagmus of Walsh."

Orbital exenteration--simplified.

In summary, a simplified technique of orbital exenteration has been presented. Results, with complications, in eleven cases have been described. The advantages of the operative method described are: (1) full thickness skin provides better cushion for self-retaining prosthesis, (2) skin with intact blood supply is much less likely to be rejected, (3) no donor site with added discomfort and care, (4) local recurrence of neoplasm is easily detected, (5) operating time shortened and (6) favorable patient acceptance.

Choroidal osteoma.

A 15-year-old white girl had a presumed choroidal hemangioma in the posterior pole of the right eye. The lesion appeared to grow, and we performed a phosphorous uptake test, which was positive. Subsequent studies demonstrated that the tumor was a choroidal osteoma.