Continuous sensing and quantification of body motion in infants: A systematic review.

Abnormal body motion in infants may be associated with neurodevelopmental delay or critical illness. In contrast to continuous patient monitoring of the basic vitals, the body motion of infants is only determined by discrete periodic clinical observations of caregivers, leaving the infants unattended for observation for a longer time. One step to fill this gap is to introduce and compare different sensing technologies that are suitable for continuous infant body motion quantification. Therefore, we conducted this systematic review for infant body motion quantification based on the PRISMA method (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). In this systematic review, we introduce and compare several sensing technologies with motion quantification in different clinical applications. We discuss the pros and cons of each sensing technology for motion quantification. Additionally, we highlight the clinical value and prospects of infant motion monitoring. Finally, we provide suggestions with specific needs in clinical practice, which can be referred by clinical users for their implementation. Our findings suggest that motion quantification can improve the performance of vital sign monitoring, and can provide clinical value to the diagnosis of complications in infants.

A Continuous Late-Onset Sepsis Prediction Algorithm for Preterm Infants Using Multi-Channel Physiological Signals From a Patient Monitor.

The aim of this study is to develop an explainable late-onset sepsis (LOS) prediction algorithm using continuous multi-channel physiological signals that can be applied to a patient monitor for preterm infants in a neonatal intensive care unit (NICU). The algorithm uses features on heart rate variability (HRV), respiration, and motion, based on electrocardiogram (ECG) and chest impedance (CI). In this study, 127 preterm infants were included, of whom 59 were bloodculture-proven LOS patients and 68 were control patients. Features in 24 hours before the onset of sepsis (LOS group), and an age-matched onset time point (control group) were extracted and fed into machine learning classifiers with gestational age and birth weight. We compared the prediction performance of several well-known classifiers using features from different signal channels (HRV, respiration, and motion) individually as well as their combinations. The prediction performance was evaluated using the area under the receiver-operating-characteristics curve (AUC). The best performance was achieved by an extreme gradient boosting classifier combining features from all signal channels, with an AUC of 0.88, a positive predictive value of 0.80, and a negative predictive value of 0.83 during the 6 hours preceding LOS onset. This feasibility study demonstrates the complementary predictive value of motion information in addition to cardiorespiratory information for LOS prediction. Furthermore, visualization of how each feature in the individual patient impacts the algorithm decision strengthen its interpretability. In clinical practice, it is important to motivate clinical interventions and this visualization method can help to support the clinical decision.

Central apnea detection in premature infants using machine learning.

BACKGROUND AND OBJECTIVE: Apnea of prematurity is one of the most common diagnosis in neonatal intensive care units. Apneas can be classified as central, obstructive or mixed. According to the current international standards, minimal fluctuations or absence of fluctuations in the chest impedance (CI) suggest a central apnea (CA). However, automatic detection of reduced CI fluctuations leads to a high number of central apnea-suspected events (CASEs), the majority being false alarms. We aim to improve automatic detection of CAs by using machine learning to optimize detection of CAs among CASEs. METHODS: Using an optimized algorithm for automated detection, all CASEs were detected in a population of 10 premature infants developing late-onset sepsis and 10 age-matched control patients. CASEs were inspected by two clinical experts and annotated as CAs or rejections in two rounds of annotations. A total of 47 features were extracted from the ECG, CI and oxygen saturation signals considering four 30 s-long moving windows, from 30 s before to 15 s after the onset of each CASE, using a moving step size of 5 s. Consecutively, new CA detection models were developed based on logistic regression with elastic net penalty, random forest and support vector machines. Performance was evaluated using both leave-one-patient-out and 10-fold cross-validation considering the mean area under the receiver-operating-characteristic curve (AUROC). RESULTS: The CA detection model based on logistic regression with elastic net penalty returned the highest mean AUROC when features extracted from all four time windows were included, both using leave-one-patient-out and 10-fold cross-validation (mean AUROC of 0.88 and 0.90, respectively). Feature relevance was found to be the highest for features derived from the CI. A threshold for the false positive rate in the mean receiver-operating-characteristic curve equal to 0.3 led to a high percentage of correct detections for all CAs (78.2%) and even higher for CAs followed by a bradycardia (93.4%) and CAs followed by both a bradycardia and a desaturation (95.2%), which are more critical for the well-being of premature infants. CONCLUSIONS: Models based on machine learning can lead to improved CA detection with fewer false alarms.

A Comparison of Video-based Methods for Neonatal Body Motion Detection.

Preterm infants in a neonatal intensive care unit (NICU) are continuously monitored for their vital signs, such as heart rate and oxygen saturation. Body motion patterns are documented intermittently by clinical observations. Changing motion patterns in preterm infants are associated with maturation and clinical events such as late-onset sepsis and seizures. However, continuous motion monitoring in the NICU setting is not yet performed. Video-based motion monitoring is a promising method due to its non-contact nature and therefore unobtrusiveness. This study aims to determine the feasibility of simple video-based methods for infant body motion detection. We investigated and compared four methods to detect the motion in videos of infants, using two datasets acquired with different types of cameras. The thermal dataset contains 32 hours of annotated videos from 13 infants in open beds. The RGB dataset contains 9 hours of annotated videos from 5 infants in incubators. The compared methods include background substruction (BS), sparse optical flow (SOF), dense optical flow (DOF), and oriented FAST and rotated BRIEF (ORB). The detection performance and computation time were evaluated by the area under receiver operating curves (AUC) and run time. We conducted experiments to detect motion and gross motion respectively. In the thermal dataset, the best performance of both experiments is achieved by BS with mean (standard deviation) AUCs of 0.86 (0.03) and 0.93 (0.03). In the RGB dataset, SOF outperforms the other methods in both experiments with AUCs of 0.82 (0.10) and 0.91 (0.05). All methods are efficient to be integrated into a camera system when using low-resolution thermal cameras.

Body Motion Detection in Neonates Based on Motion Artifacts in Physiological Signals from a Clinical Patient Monitor.

Motion patterns in newborns contain important information. Motion patterns change upon maturation and changes in the nature of motion may precede critical clinical events such as the onset of sepsis, seizures and apneas. However, in clinical practice, motion monitoring is still limited to observations by caregivers. In this study, we investigated a practical yet reliable method for motion detection using routinely used physiological signals in the patient monitor. Our method calculated motion measures with a continuous wavelet transform (CWT) and a signal instability index (SII) to detect gross-motor motion in 15 newborns using 40 hours of physiological data with annotated videos. We compared the performance of these measures on three signal modalities (electrocardiogram ECG, chest impedance, and photo plethysmography). In addition, we investigated whether their combinations increased performance. The best performance was achieved with the ECG signal with a median (interquartile range, IQR) area under receiver operating curve (AUC) of 0.92(0.87-0.95), but differences were small as both measures had a robust performance on all signal modalities. We then applied the algorithm on combined measures and modalities. The full combination outperformed all single-modal methods with a median (IQR) AUC of 0.95(0.91-0.96) when discriminating gross-motor motion from still. Our study demonstrates the feasibility of gross-motor motion detection method based on only clinically-available vital signs and that best results can be obtained by combining measures and vital signs.

Optimized Detection of Central Apneas Preceding Late-Onset Sepsis in Premature Infants.

In neonatal intensive care units, respiratory traces of premature infants developing late onset sepsis (LOS) may also show episodes of apneas. However, since clinical patient monitors often underdetect apneas, clinical experts are required to investigate patients' traces looking for these events. In this work we present a method to optimize an existing algorithm for central apnea (CA) detection and how we used it together with human annotations to investigate the occurrence of CAs preceding LOS.The algorithm was optimized by using a previously-annotated dataset consisting of 90 hours, extracted from 10 premature infants. This allowed to double precision (19.7% vs 9.3%, median values per patient) without affecting recall (90.5% vs 94.5%) compared to the original algorithm. This choice caused the missed identification of just 1 additional CA (4 vs 3) in the whole dataset. The optimized algorithm was then used to annotate a second dataset consisting of 480 hours, extracted from 10 premature infants diagnosed with LOS. Annotations were corrected by two clinical experts.A significantly higher number of CA annotations was found in the 6 hours prior to sepsis onset (p-value < 0.05). The use of the optimized algorithm followed by human annotations proved to be a suitable, time-efficient method to annotate CAs before sepsis in premature infants, enabling future use in large datasets.

A physiology-based model describing heterogeneity in glucose metabolism: the core of the Eindhoven Diabetes Education Simulator (E-DES).

Current diabetes education methods are costly, time-consuming, and do not actively engage the patient. Here, we describe the development and verification of the physiological model for healthy subjects that forms the basis of the Eindhoven Diabetes Education Simulator (E-DES). E-DES shall provide diabetes patients with an individualized virtual practice environment incorporating the main factors that influence glycemic control: food, exercise, and medication. The physiological model consists of 4 compartments for which the inflow and outflow of glucose and insulin are calculated using 6 nonlinear coupled differential equations and 14 parameters. These parameters are estimated on 12 sets of oral glucose tolerance test (OGTT) data (226 healthy subjects) obtained from literature. The resulting parameter set is verified on 8 separate literature OGTT data sets (229 subjects). The model is considered verified if 95% of the glucose data points lie within an acceptance range of ±20% of the corresponding model value. All glucose data points of the verification data sets lie within the predefined acceptance range. Physiological processes represented in the model include insulin resistance and ß-cell function. Adjusting the corresponding parameters allows to describe heterogeneity in the data and shows the capabilities of this model for individualization. We have verified the physiological model of the E-DES for healthy subjects. Heterogeneity of the data has successfully been modeled by adjusting the 4 parameters describing insulin resistance and ß-cell function. Our model will form the basis of a simulator providing individualized education on glucose control.