RESUMO
Cancer Care Ontario developed a diagnostic assessment program (DAP) to improve patients' experience in the diagnostic phase of their cancer journey and improve health system efficiency and effectiveness. The Stronach Regional Cancer Centre Lung DAP (at Southlake Regional Health Centre) used learnings from a Lean improvement event to increase capacity to meet patient demand for service and to achieve/improve upon the provincial wait time target from consultation to diagnosis for lung cancer patients (65% within 28 days), improving overall patient experience of care. Monthly patient volumes have increased by 65%, and wait time has improved by 60%.
Assuntos
Eficiência Organizacional , Neoplasias Pulmonares/diagnóstico , Melhoria de Qualidade/organização & administração , Encaminhamento e Consulta/organização & administração , Agendamento de Consultas , Humanos , Biópsia Guiada por Imagem/estatística & dados numéricos , Ontário , Encaminhamento e Consulta/normas , Fatores de Tempo , Listas de EsperaAssuntos
Pessoal de Laboratório/psicologia , Microbiologia/organização & administração , Comportamento Cooperativo , Organização do Financiamento , Humanos , Pessoal de Laboratório/economia , Microbiologia/economia , Parcerias Público-Privadas , Sociedades Científicas/economia , Sociedades Científicas/organização & administraçãoRESUMO
Children with autism spectrum disorders (ASD) may be impaired in their ability to detect audiovisual synchrony and their ability may be influenced by the nature of the stimuli. We investigated the possibility that synchrony detection is disrupted by the presence of human faces by testing children with ASD using a preferential looking language-based paradigm. Children with low language abilities were significantly worse at detecting synchrony when the stimuli include an unobscured face than when the face was obscured. Findings suggest that the presence of faces may make multisensory processing more difficult. Implications for interventions are discussed, particularly those targeting attention to faces.
Assuntos
Atenção/fisiologia , Transtorno do Espectro Autista/fisiopatologia , Transtorno do Espectro Autista/psicologia , Comunicação , Aprendizagem por Discriminação/fisiologia , Reconhecimento Facial/fisiologia , Desenvolvimento da Linguagem , Linguística , Reconhecimento Visual de Modelos/fisiologia , Percepção da Fala/fisiologia , Transtorno do Espectro Autista/diagnóstico , Córtex Cerebral/fisiopatologia , Pré-Escolar , Feminino , Humanos , Relações Interpessoais , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Transtornos do Desenvolvimento da Linguagem/fisiopatologia , Transtornos do Desenvolvimento da Linguagem/psicologia , Masculino , Relações Mãe-Filho , Aprendizagem por Associação de Pares/fisiologia , Mascaramento PerceptivoRESUMO
A 40 kb genomic clone and 2.3 kb EcoRI subclone that rescued the DNA repair and recombination defects of the Aspergillus nidulans nuvA11 mutant were isolated and the subclone sequenced. The subclone hybridized to a cosmid in a chromosome-specific library confirming the assignment of nuvA to linkage group IV and indicating its closeness to bimD. Amplification by PCR clarified the relative positions of nuvA and bimD. A region identified within the subclone, encoding a C3HC4 zinc finger motif, was used as a probe to retrieve a cDNA clone. Sequencing of this clone showed that the nuvA gene has an ORF of 1329 bp with two introns of 51 bp and 60 bp. Expression of nuvA appears to be extremely low. The putative NUVA polypeptide has two zinc finger motifs, a molecular mass of 48906 Da and has 39% identity with the Neurospora crassa uvs-2 and 25% identity with the Saccharomyces cerevisiae RAD18 translation products. Although mutations in nuvA, uvs-2 and RAD18 produce similar phenotypes, only the nuvA11 mutation affects meiotic recombination. A role for nuvA in both DNA repair and genetic recombination is proposed.
