Subcutaneous bortezomib in newly diagnosed patients with multiple myeloma nontransplant eligible: Retrospective evaluation.

Bortezomib-melphalan-prednisone combination is one of the standards of care for nontransplant eligible patients with newly diagnosed multiple myeloma. However, bortezomib intravenous (twice weekly for 4 cycles then weekly for 5 cycles) results in ~13% of patients with grade 3-4 peripheral neuropathy. Bortezomib subcutaneous (SQ) and weekly delivery, improves tolerability without impairment of efficacy. The aim of this study was to evaluate the safety and effectiveness of SQ bortezomib-based combinations in nontransplant eligible patients with newly diagnosed myeloma in a real-world setting. A total of 135 patients (median age [range] = 76 [58-89], International Staging System-III = 54%, median follow-up = 14.8 months [1-40], Intensive group [twice weekly bortezomib] = 65%, Optimized group [weekly bortezomib] = 35%) were included and evaluable for safety, whereas 121 were evaluable for effectiveness. Overall response rate (95% CI) was 61% (53%, 71%) (complete response = 27%, very good partial response = 13%, and partial response = 21%) and median progression-free survival was 22.2 months (95% CI: 16.1-not reached). The 3-year overall survival was 75%. The most frequent grade 3-4 adverse events were thrombocytopenia (18%), neutropenia (17%), and anemia (11%). Peripheral neuropathy of any grade was observed in 44% of patients (2% with grade 3). Comparison between regimens (Intensive vs Optimized) showed similar overall response rate (57% vs 70%) and PFS (25 vs 19 months). A similar safety profile was observed between regimens. Thus, SQ bortezomib showed similar effectiveness and better tolerability as compared with results from intravenous bortezomib studies, and showing no differences either in effectiveness or safety in different bortezomib-based combinations.

La práctica del botellón en adolescentes gallegos: prevalencia, implicaciones y variables asociadas / Binge drinking in Galician adolescents: Prevalence, implications and related variables

El fenómeno del botellón ha contribuido a la expansión y consolidación de un patrón de consumo de alcohol preocupante en forma de atracón. Pese a ello existen pocos estudios que lo analicen, siendo éste precisamente el objetivo del presente trabajo. Los resultados obtenidos con una muestra de 3.419 adolescentes de entre 12 y 18 años (M=14,94; DT= 1,89) sitúan la prevalencia del botellón en un 38,4%. Su práctica implica tasas de consumo de otras sustancias significativamente mayores, siendo hasta 16 veces superior en el caso del consumo intensivo (binge drinking), así como mayores tasas de consumo de riesgo. Asimismo, se asocia con numerosas prácticas de riesgo, como peleas, accidentes o sexo sin protección. Las expectativas, el consumo de los iguales, la hora de llegada a casa o el dinero disponible se han mostrado asociadas con esta práctica. Todo ello refuerza la conveniencia de desarrollar una labor preventiva integral que contemple tanto variables de naturaleza personal como aquellas más estrechamente relacionadas con el establecimiento de normas y límites por parte de los padres

The phenomenon of botellón (binge drinking) among adolescents has contributed to the expansion and consolidation of a worrying pattern of alcohol consumption. However, there are few studies that analyze it, being this the objective of the paper. The results obtained with a sample of 3,419 adolescents aged between 12 and 18 years (M= 14.94, SD= 1.89) put the prevalence of botellón at 38.4%. Its practice involves consumption rates of other substances significantly higher, being up to 16 times higher in the case of binge drinking, as well as higher risk consumption levels. Likewise, it is associated with several highrisk practices such as fights, accidents or unprotected sex. Variables such as expectations, peers consumption, curfew or spending money have been shown to be associated with this practice. All this reinforces the convenience of developing comprehensive preventive work that includes both variables of a personal nature and those more closely related to the establishment of norms and limits by the parents

Evaluation and early detection of problematic Internet use in adolescents / Evaluación y detección precoz del uso problemático de Internet entre adolescentes

BACKGROUND: Problematic Internet use in adolescents has become an issue of concern for a growing number of researchers and institutions over the past years. Behavioural problems, social isolation, school failure and family problems are some of the consequences of psychological and behavioural impact on teenagers. Taking into account the interest that this issue has generated at many levels, the aim of this paper is to develop a screening tool for early detection of problematic Internet use in teenagers. METHOD: A survey of Compulsory Secondary School students from Galicia involving a total of 2,339 individuals was carried out. RESULTS: The results obtained allow (1) gauging the magnitude of the problem, establishing the risk levels among the adolescents, and (2) presenting a new, simple and short screening instrument. CONCLUSIONS: The present scale has sufficient theoretical and empirical support, including good psychometric properties (a= .83; specificity = .81; sensitivity = .80; ROC curve = .90), making it an interesting applied tool

ANTECEDENTES: el uso problemático de Internet entre los adolescentes preocupa cada vez más a investigadores e instituciones. Problemas de conducta, aislamiento social, fracaso escolar y problemas familiares son algunas de las consecuencias del impacto a nivel psicológico y conductual que ello produce. Habida cuenta del interés que el tema suscita a diferentes niveles, el objetivo de este trabajo es desarrollar una herramienta de screening para la detección precoz de uso problemático de Internet entre adolescentes. MÉTODO: se realizó una encuesta a escolares de Enseñanza Secundaria Obligatoria de la comunidad gallega, en la que participaron un total de 2.339 individuos. RESULTADOS: los resultados obtenidos permiten: (1) evaluar la magnitud del problema, permitiendo conocer los niveles de riesgo existente, y (2) presentar un nuevo instrumento de screening o cribado, breve y sencillo. CONCLUSIONES: la presente escala cuenta con suficiente aval teórico y empírico y con unas buenas propiedades psicométricas (a= ,83; especificidad = ,81; sensibilidad = ,80; Curva COR = ,90), lo cual la convierte en una herramienta de interés a nivel aplicado

Evaluation and early detection of problematic Internet use in adolescents.

BACKGROUND: Problematic Internet use in adolescents has become an issue of concern for a growing number of researchers and institutions over the past years. Behavioural problems, social isolation, school failure and family problems are some of the consequences of psychological and behavioural impact on teenagers. Taking into account the interest that this issue has generated at many levels, the aim of this paper is to develop a screening tool for early detection of problematic Internet use in teenagers. METHOD: A survey of Compulsory Secondary School students from Galicia involving a total of 2,339 individuals was carried out. RESULTS: The results obtained allow (1) gauging the magnitude of the problem, establishing the risk levels among the adolescents, and (2) presenting a new, simple and short screening instrument. CONCLUSIONS: The present scale has sufficient theoretical and empirical support, including good psychometric properties (a = .83; specificity = .81; sensitivity = .80; ROC curve = .90), making it an interesting applied tool.

Genetic analysis of CAV1 gene in hypertension and metabolic syndrome.

Recently, we reported that the polymorphism 1132T>C (GenBank: AF519768.1) of the NOS3 gene was associated with susceptibility to metabolic syndrome (MS) in hypertensive patients. This suggests that other genes such as CAV1, whose product (CAV1) regulates eNOS activity, could also be related to this phenotype. In this work we investigated the following: i) whether CAV1 is a quantitative trait locus of clustering of atherothrombotic traits associated with MS; ii) whether CVA1 is associated with hypertension or MS in hypertensive patients; and iii) whether genetic interaction between NOS3 and CAV1 is involved in the susceptibility or protection to hypertension associated with MS. To carry out the study, we genotyped 285 randomly selected individuals and 175 hypertensive patients, all of them < or = 60 years old, with two polymorphisms of the CAV1 gene: the 22285 C>T and the 22375-22375 del AC (GenBank AF125348), and the 1132T>C polymorphism of the NOS3 gene. To perform sample genotyping, we used pyrosequencing and FRET techniques. The 22285 C-22375-22375 del (Cd) haplotype of CAV1 gene was associated with low levels of blood pressure in the general population. Moreover, it was a genetic protection factor against MS in hypertensive patients. In addition, we found no evidence of gene-gene interaction between NOS3 and CAV1 genes with regard to that phenotype.

Association of NOS3 gene with metabolic syndrome in hypertensive patients.

Recent data from animal models indicate that the eNOS null mice present a phenotype that resemble the human metabolic syndrome (hypertension, insulin resistance and hypertriglyceridemia). In this work, we have studied whether NOS3 gene, previously related to endothelial dysfunction, might have a role in metabolic syndrome susceptibility in hypertensive patients. To carry out the study, we genotyped 105 hypertensive patients < or = 60 years old with two polymorphisms of NOS3 gene: 1132 T>C and 7164 G>T (GeneBank:AF519768.1). To check the allelic frequency of these polymorphisms in our geographical area, we also genotyped 94 unselected healthy controls (control group). To perform sample genotyping, we designed a novel FRET system coupled to real time PCR. There were no differences in genotypic distribution or allelic frequency between hypertensive patients and the control group. However, we observed that 786CC genotype was significantly more frequent in hypertensive patients with metabolic syndrome than in those without the syndrome (p=0.0022). When both polymorphisms were analyzed, we identified the 786C894G as the risk haplotype for metabolic syndrome susceptibility (p=0.011). These data suggest a role of the NOS3 gene in the pathogenesis of metabolic syndrome in hypertensive patients.