RESUMO
Sixty-seven patients with gynecologic malignant disease received continuous epidural morphine as a postoperative analgesic after radical surgical treatment. An average of 0.005 milligrams per kilogram of body weight per hour of morphine was given, with a mean total postoperative dose of 33.42 milligrams. Pain control was excellent in 88 per cent of the patients and no major complications occurred with this technique. Side effects included: nausea (33 per cent); vomiting (9 per cent), and generalized pruritus (25 per cent). Epidural morphine provided a constant pain-free state with unimpaired consciousness, normal motor function and hemodynamic stability. This technique allows the early institution of aggressive physiotherapy with an actively participating patient and provides an ideal postoperative analgesia for the high risk patient to be cared for in an intensive nursing area.
Assuntos
Neoplasias dos Genitais Femininos/cirurgia , Morfina/administração & dosagem , Dor Pós-Operatória/tratamento farmacológico , Adulto , Idoso , Idoso de 80 Anos ou mais , Espaço Epidural , Feminino , Humanos , Bombas de Infusão , Pessoa de Meia-Idade , Morfina/efeitos adversos , Náusea/induzido quimicamente , Prurido/induzido quimicamenteRESUMO
Arterial blood pressure and pulse rate changes following tracheal intubation were studied in 20 patients undergoing intracranial surgery who received a thiopentone/suxamethonium anaesthetic induction sequence. Ten of the patients were pretreated with 0.4 mg/kg of hydrallazine and 10 with saline to determine whether hydrallazine prevents intubation hypertension. The results show that the incidence of intubation hypertension can be reduced using this dose of hydrallazine. Hydrallazine pretreatment is therefore recommended in patients at risk from hypertension following tracheal intubation.
Assuntos
Hidralazina/uso terapêutico , Hipertensão/prevenção & controle , Intubação Intratraqueal/efeitos adversos , Pré-Medicação , Adulto , Anestesia Geral , Encéfalo/cirurgia , Ensaios Clínicos como Assunto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Distribuição Aleatória , Succinilcolina , TiopentalRESUMO
A general review of the physiological alterations with artificial ventilation is presented with particular emphasis on the alteration of inspiratory time and flow waveform. The general methods and physiological calibration procedures used in a more elaborate study of inspiratory time and waveform effects are described, with the results of testing these methods showing that the model is satisfactory.
Assuntos
Respiração com Pressão Positiva Intermitente , Respiração com Pressão Positiva , Ventilação Pulmonar , Animais , Débito Cardíaco , Cães , Respiração com Pressão Positiva Intermitente/métodos , Modelos Biológicos , Oxigênio/sangue , Respiração com Pressão Positiva/métodos , Fatores de TempoRESUMO
The autonomic nervous system was blocked in dogs which were exposed to independent alterations in inspiratory flow waveform and time whilst being ventilated artificially at a constant volume and frequency. There were statistically significant differences in cardiac output between the control and blocked states, but these differences were not of marked physiological significance. Alteration in inspiratory waveform or time in the blocked animals did not alter cardiac output significantly.
