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Virology ; 512: 222-233, 2017 12.
Artigo em Inglês | MEDLINE | ID: mdl-29020646

RESUMO

HIV subtypes not only predominate in different geographical regions but also differ in key phenotypic characteristics. To determine if genotypic and/or phenotypic differences in the Envelope (Env) glycoprotein can explain subtype related differences, we cloned 37 full length Envs from Subtype B and AE HIV infected individuals from Singapore. Our data demonstrates that CRF01_AE Envs have lower Potential N Glycosylation Sites and higher risk of ×4 development. Phenotypically, CRF01_AE were less infectious than subtype B Envs in cells expressing low levels of CCR5. Moreover, the Maraviroc IC50 was higher for subtype B Envs and correlated with infectivity in low CCR5 expressing cells as well as PNGS. Specifically, the glycosylation site N301 in the V3 loop was seen less frequently in AE subtype and CXCR4 topic viruses. CRF01_AE differs from B subtype in terms of CCR5 usage and Maraviroc susceptibility which may have implications for HIV pathogenesis and virus evolution.


Assuntos
Cicloexanos/farmacologia , HIV-1/classificação , Receptores CCR5/metabolismo , Triazóis/farmacologia , Produtos do Gene env do Vírus da Imunodeficiência Humana/metabolismo , Linhagem Celular , Clonagem Molecular , Regulação Viral da Expressão Gênica/fisiologia , Glicosilação , HIV-1/genética , Humanos , Maraviroc , Modelos Moleculares , Conformação Proteica , Replicação Viral , Produtos do Gene env do Vírus da Imunodeficiência Humana/genética
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