Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 8 de 8
Filtrar
1.
J Infect Dis ; 222(Suppl 5): S451-S457, 2020 09 02.
Artigo em Inglês | MEDLINE | ID: mdl-32877550

RESUMO

BACKGROUND: Increases in fatal drug poisonings and hepatitis C infections associated with the opioid epidemic are relatively well defined, because passive surveillance systems for these conditions exist. Less described is the association between the opioid epidemic and skin, soft-tissue, and venous infections (SSTVIs), endocarditis, sepsis, and osteomyelitis. METHODS: Michigan hospitalizations between 2016 and 2018 that included an International Classification of Diseases, Tenth Revision, Clinical Modification, code indicating substance use were examined for codes indicative of infectious conditions associated with injecting drugs. Trends in these hospitalizations were examined, as were demographic characteristics, discharge disposition, payer, and cost data. RESULTS: Among hospitalized patients with a substance use diagnosis code, endocarditis, osteomyelitis, sepsis, and SSTVI hospitalizations increased by 33%, 35%, 24%, and 12%, respectively between 2016 and 2018. During this time frame, 1257 patients died or were discharged to hospice. All SSTVI hospitalizations resulted in >$1.3 billion in healthcare costs. Public insurance accounted for more than two-thirds of all hospitalization costs. CONCLUSIONS: This study describes a method for performing surveillance for infection-related sequelae of injection drug use. Endocarditis, osteomyelitis, sepsis, and SSTVI hospitalizations have increased year over year between 2016 and 2018. These hospitalizations result in significant morbidity, mortality, and healthcare costs and should be a focus of future surveillance and prevention efforts.


Assuntos
Infecções Bacterianas/epidemiologia , Custos de Cuidados de Saúde/estatística & dados numéricos , Hospitalização/estatística & dados numéricos , Transtornos Relacionados ao Uso de Opioides/complicações , Adolescente , Adulto , Infecções Bacterianas/economia , Infecções Bacterianas/microbiologia , Infecções Bacterianas/terapia , Monitoramento Epidemiológico , Feminino , Hospitalização/economia , Humanos , Masculino , Pessoa de Meia-Idade , Epidemia de Opioides/estatística & dados numéricos , Transtornos Relacionados ao Uso de Opioides/economia , Transtornos Relacionados ao Uso de Opioides/epidemiologia , Estudos Retrospectivos , Estados Unidos/epidemiologia , Adulto Jovem
3.
Am J Epidemiol ; 187(11): 2415-2422, 2018 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-30099475

RESUMO

Accurate interpretations and comparisons of record linkage results across jurisdictions require valid and reliable matching methods. We compared existing matching methods used by 6 US state and local health departments (Houston, Texas; Louisiana; Michigan; New York, New York; North Dakota; and Wisconsin) to link human immunodeficiency virus and viral hepatitis surveillance data with a 14-key automated, hierarchical deterministic matching method. Applicable years of study varied by disease and jurisdiction, ranging from 1979 to 2016. We calculated percentage agreement and Cohen's κ coefficient to compare the matching methods used within each jurisdiction. We calculated sensitivity, specificity, and positive predictive value for each matching method, as compared with a new standard that included manual review of discrepant cases. Agreement between the existing matching method and the deterministic matching method was 99.6% or higher in all jurisdictions; Cohen's κ values ranged from 0.87 to 0.98. The sensitivity of the deterministic matching method ranged from 97.4% to 100% in the 6 jurisdictions; specificity ranged from 99.7% to 100%; and positive predictive value ranged from 97.4% to 100%. Although no gold standard exists, prior assessments of existing methods and review of discrepant classifications suggest good accuracy and reliability of our deterministic matching method, with the advantage that our method reduces the need for manual review and allows for standard comparisons across jurisdictions when linking human immunodeficiency virus and viral hepatitis data.


Assuntos
Algoritmos , Infecções por HIV/epidemiologia , Hepatite B/epidemiologia , Hepatite C/epidemiologia , Registro Médico Coordenado/métodos , Vigilância em Saúde Pública/métodos , Humanos , Registro Médico Coordenado/normas , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Estados Unidos/epidemiologia
4.
Pain Med ; 18(2): 322-329, 2017 02 01.
Artigo em Inglês | MEDLINE | ID: mdl-28204717

RESUMO

Background: In 2015, the Michigan Department of Health and Human Services (MDHHS) was notified of an acute case of hepatitis C virus (HCV). The patient had no traditional HCV risk factors. The only known subcutaneous exposure was health care received at a pain management clinic. Design: A field investigation was undertaken to determine the likely route of HCV acquisition and assess potential risk to other patients. Setting and Patients: The investigation involved a free-standing outpatient pain management clinic and its patients with a subcutaneous exposure. Methods: Investigators utilized the Centers for Disease Control and Prevention's (CDC) viral hepatitis health care-associated infection investigation protocol to guide field investigation, assess risk to patients, perform patient notification, and test patients for blood-borne pathogens. Results: The index case was found to be the final patient seen in the clinic's operating room for the week. Examining the MDHHS viral hepatitis registry revealed another acute HCV patient seen immediately before the index case. The second acute case was preceded by a patient chronically infected with HCV. Due to the possibility of patient-to-patient HCV transmission, 122 patients were recommended to be tested for blood-borne pathogens. Ninety-two patients presented for testing. No additional transmission events were discovered. Conclusion: Health care-associated transmission of HCV likely occurred at an outpatient pain management clinic; possibly the result of multiple patient use of single-dose vials. Because no other cases were discovered this may represent an isolated incident as opposed to a systematic breakdown in infection control standards. This circumstance highlights the need for continued vigilance and adherence to CDC's Minimum Expectations for Safe Care in Outpatient Settings.


Assuntos
Infecção Hospitalar , Hepatite C/transmissão , Manejo da Dor , Instituições de Assistência Ambulatorial , Feminino , Humanos , Controle de Infecções , Michigan , Manejo da Dor/métodos , Medição de Risco
5.
Infect Control Hosp Epidemiol ; 36(11): 1283-91, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26399907

RESUMO

BACKGROUND: The pandemic of carbapenem-resistant Enterobacteriaceae (CRE) was primarily due to clonal spread of bla KPC producing Klebsiella pneumoniae. Thus, thoroughly studied CRE cohorts have consisted mostly of K. pneumoniae. OBJECTIVE: To conduct an extensive epidemiologic analysis of carbapenem-resistant Enterobacter spp. (CREn) from 2 endemic and geographically distinct centers. METHODS: CREn were investigated at an Israeli center (Assaf Harofeh Medical Center, January 2007 to July 2012) and at a US center (Detroit Medical Center, September 2008 to September 2009). bla KPC genes were queried by polymerase chain reaction. Repetitive extragenic palindromic polymerase chain reaction and pulsed-field gel electrophoresis were used to determine genetic relatedness. RESULTS: In this analysis, 68 unique patients with CREn were enrolled. Sixteen isolates (24%) were from wounds, and 33 (48%) represented colonization only. All isolates exhibited a positive Modified Hodge Test, but only 93% (27 of 29) contained bla KPC. Forty-three isolates (63%) were from elderly adults, and 5 (7.4%) were from neonates. Twenty-seven patients died in hospital (40.3% of infected patients). Enterobacter strains consisted of 4 separate clones from Assaf Harofeh Medical Center and of 4 distinct clones from Detroit Medical Center. CONCLUSIONS: In this study conducted at 2 distinct CRE endemic regions, there were unique epidemiologic features to CREn: (i) polyclonality, (ii) neonates accounting for more than 7% of cohort, and (iii) high rate of colonization (almost one-half of all cases represented colonization). Since false-positive Modified Hodge Tests in Enterobacter spp. are common, close monitoring of carbapenem resistance mechanisms (particularly carbapenemase production) among Enterobacter spp. is important.


Assuntos
Farmacorresistência Bacteriana , Enterobacter/isolamento & purificação , Infecções por Enterobacteriaceae/epidemiologia , Klebsiella pneumoniae/isolamento & purificação , Tempo de Internação/estatística & dados numéricos , Adulto , Idoso , Idoso de 80 Anos ou mais , Antibacterianos/farmacologia , Carbapenêmicos/farmacologia , DNA Bacteriano/genética , Eletroforese em Gel de Campo Pulsado , Enterobacter/genética , Feminino , Humanos , Israel , Estimativa de Kaplan-Meier , Klebsiella pneumoniae/genética , Modelos Logísticos , Masculino , Michigan , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , Análise Multivariada , Reação em Cadeia da Polimerase , Estudos Retrospectivos , Índice de Gravidade de Doença
6.
Future Microbiol ; 10(5): 819-39, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26000652

RESUMO

Antimicrobial resistance is a growing worldwide iatrogenic complication of modern medical care. Extended-spectrum ß-lactamases have emerged as one of the most successful resistance mechanisms, limiting our therapeutic options to treat various human infections. The dissemination of these enzymes to the community probably signifies an irreversible step. This paper will review the evolution of human infections associated with extended-spectrum ß-lactamase-producing organisms in the past 20 years, and will present and discuss the current challenges, controversies, debates and knowledge gaps in this research field.


Assuntos
Infecções por Enterobacteriaceae/epidemiologia , Infecções por Enterobacteriaceae/microbiologia , Enterobacteriaceae/enzimologia , beta-Lactamases/metabolismo , Farmacorresistência Bacteriana , Enterobacteriaceae/isolamento & purificação , Humanos
7.
Infect Control Hosp Epidemiol ; 35(4): 342-9, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24602937

RESUMO

BACKGROUND: Carbapenem-resistant Enterobacteriaceae (CRE) are clinically challenging, threaten patient safety, and represent an emerging public health issue. CRE reporting is not mandated in Michigan. METHODS: The Michigan Department of Community Health-led CRE Surveillance and Prevention Initiative enrolled 21 facilities (17 acute care and 4 long-term acute care facilities) across the state. Baseline data collection began September 1, 2012, and ended February 28, 2013 (duration, 6 months). Enrolled facilities voluntarily reported cases of Klebsiella pneumoniae and Escherichia coli according to the surveillance algorithm. Patient demographic characteristics, laboratory testing, microbiology, clinical, and antimicrobial information were captured via standardized data collection forms. Facilities reported admissions and patient-days each month. RESULTS: One-hundred two cases over 957,220 patient-days were reported, resulting in a crude incidence rate of 1.07 cases per 10,000 patient-days. Eighty-nine case patients had test results positive for K. pneumoniae, whereas 13 had results positive for E. coli. CRE case patients had a mean age of 63 years, and 51% were male. Urine cultures (61%) were the most frequently reported specimen source. Thirty-five percent of cases were hospital onset; sixty-five percent were community onset (CO), although 75% of CO case patients reported healthcare exposure within the previous 90 days. Cardiovascular disease, renal failure, and diabetes mellitus were the most frequently reported comorbid conditions. Common ris k factors included surgery within the previous 90 days, recent infection or colonization with a multidrug-resistant organism, and recent exposures to antimicrobials, especially third- or fourth-generation cephalosporins. CONCLUSIONS: CRE are found throughout Michigan healthcare facilities. Implementing a regional, coordinated surveillance and prevention initiative may prevent CRE from becoming hyperendemic in Michigan.


Assuntos
Antibacterianos/uso terapêutico , Carbapenêmicos/uso terapêutico , Farmacorresistência Bacteriana , Infecções por Enterobacteriaceae/epidemiologia , Enterobacteriaceae/isolamento & purificação , Vigilância da População , Adulto , Idoso , Idoso de 80 Anos ou mais , Antibacterianos/farmacologia , Carbapenêmicos/farmacologia , Intervalos de Confiança , Infecção Hospitalar , Enterobacteriaceae/efeitos dos fármacos , Infecções por Enterobacteriaceae/tratamento farmacológico , Feminino , Humanos , Masculino , Michigan/epidemiologia , Pessoa de Meia-Idade , Adulto Jovem
8.
Am J Infect Control ; 42(3): 283-7, 2014 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-24581017

RESUMO

BACKGROUND: Acinetobacter baumannii infections are common and associated with high mortality and costs. Early identification of asymptomatic carriers can reduce patient-to-patient transmission, but the sensitivity of A baumannii surveillance tools is poor, and thus active surveillance is not routine practice. This study examined whether an active surveillance screening policy can reduce the transmission, mortality, and costs associated with A baumannii. METHODS: A simulation model was developed to determine the impact of active screening on patient outcomes. Model parameters included A baumannii prevalence, screening sensitivity and specificity, probability of transmission, progression from colonization to infection, mortality, and cost of screening, contact precautions, and infection. A scenario analysis was performed to evaluate the robustness of the results when varying the sensitivity of the screening test and the prevalence rate of A baumannii. RESULTS: Assuming a screening sensitivity of 55%, active screening reduced A baumannii transmissions, infections, and deaths by 48%. As the screening sensitivity approached 90%, the reduction in transmissions, infections, and deaths reached 78%. For all scenarios tested, active surveillance was cost saving (19%-53% reduction in mean hospital cost per patient) except at a carrier prevalence of ≤2% and screening test sensitivity of ≤55%. CONCLUSIONS: In institutions where A baumannii is endemic or during epidemics, implementing a surveillance program is cost-saving and can greatly reduce transmissions and deaths. Methodologies to improve the sensitivity of surveillance testing will help optimize the clinical impact of active screening programs on preventing the spread of A baumannii in health care facilities.


Assuntos
Infecções por Acinetobacter/prevenção & controle , Acinetobacter baumannii/isolamento & purificação , Infecção Hospitalar/prevenção & controle , Transmissão de Doença Infecciosa/prevenção & controle , Monitoramento Epidemiológico , Controle de Infecções/economia , Controle de Infecções/métodos , Infecções por Acinetobacter/epidemiologia , Infecções por Acinetobacter/transmissão , Simulação por Computador , Análise Custo-Benefício , Infecção Hospitalar/epidemiologia , Infecção Hospitalar/transmissão , Política de Saúde , Humanos , Modelos Estatísticos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...