Highlighting health consequences of racial disparities sparks support for action.

Racial disparities arise across many vital areas of American life, including employment, health, and interpersonal treatment. For example, one in three Black children lives in poverty (versus one in nine white children), and, on average, Black Americans live four fewer years compared with white Americans. Which disparity is more likely to spark reduction efforts? We find that highlighting disparities in health-related (versus economic) outcomes spurs greater social media engagement and support for disparity-mitigating policy. Further, reading about racial health disparities elicits greater support for action (e.g., protesting) compared with economic- or belonging-based disparities. This occurs in part because people view health disparities as violating morally sacred values, which enhances perceived injustice. This work elucidates which manifestations of racial inequality are most likely to prompt Americans to action.

Stereotypes About Political Attitudes and Coalitions Among U.S. Racial Groups: Implications for Strategic Political Decision-Making.

What are people's expectations of interracial political coalitions? This research reveals expectations of flexible interracial coalitions stemming from how policies and racial groups are viewed in terms of perceived status and foreignness. For policies seen as changing societal status (e.g., welfare), people expected Black-Hispanic political coalitions and viewed Asian Americans as more likely to align with Whites than with other minorities. For policies seen as impacting American identity (e.g., immigration), people expected Asian-Hispanic coalitions and that Black Americans would align with Whites more than other minorities. Manipulating a novel group's alleged status and cultural assimilation influenced coalitional expectations, providing evidence of causality. These expectations appear to better reflect stereotypes than groups' actual average policy attitudes and voting behavior. Yet these beliefs may have implications for a diversifying electorate as White Americans strategically amplified the political voice of a racial group expected to agree with their personal preferences on stereotyped policies.

Framing economic inequality and policy as group disadvantages (versus group advantages) spurs support for action.

Given the near-historic levels of economic inequality in the United States, it is vital to understand when and why people are motivated to reduce it. We examine whether the manner in which economic inequality and policy are framed-in terms of either upper-socio-economic-class advantages or lower-socio-economic-class disadvantages-influences individuals' reactions to inequality. Across five studies, framing redistributive policy (Study 1) as disadvantage-reducing (versus advantage-reducing) and economic inequality (Studies 2-5) as lower-class disadvantages (versus upper-class advantages or a control frame) enhances support for action to reduce inequality. Moreover, increased support is partly driven by perceptions that inequality is more unjust if framed as lower-class disadvantages. Using diverse methodologies (for example, social media engagement on Facebook) and nationally representative samples of self-reported upper-class and lower-class individuals, this work suggests that the ways in which economic inequality is communicated (for example, by the media) may reliably influence people's reactions to and concern for the issue.

Acting for whom, against what? Group membership and multiple paths to engagement in social change.

In a connected and politically engaged world, it is essential to understand how, why, and when people from diverse backgrounds may support social action. Integrating findings from the collective action, solidarity, and allyship literatures, we present working models of how the lenses through which individuals possessing different group memberships may psychologically identify (as part of the targeted group, an inclusive stigmatized identity, or the societally dominant group) and perceive injustice (as exclusively affecting the targeted group, inclusively affecting the target group and one's ingroup, or perceiving ingroup privileges) may shape social change efforts. We highlight disparate effects of positive (and negative) contact between groups on the mobilization of socially dominant and stigmatized groups that may provide challenges to diverse coalitions seeking social change.

Intergroup Inequality Heightens Reports of Discrimination Along Alternative Identity Dimensions.

How do members of societally valued (dominant) groups respond when considering inequality? Prior research suggests that salient inequality may be viewed as a threat to dominant-group members' self and collective moral character. However, people possess multiple social identities and may be advantaged in one domain (e.g., White) while concurrently disadvantaged in another domain (e.g., sexual minority). The present research tests whether individuals may reduce the moral-image threat of being societally advantaged in one domain by highlighting discrimination they face in other domains. Four experiments with individuals advantaged along different dimensions of inequality (race, social class, sexuality) reveal that making such inequality salient evokes greater perceived discrimination faced by oneself and one's ingroups along other identity dimensions.

Preventive dental care use for children with special health care needs in Washington's Access to Baby and Child Dentistry program.

BACKGROUND: Preschool-aged children with special health care needs (CSHCN) from low-income households are at increased risk of developing poor oral health. The study goal was to assess preventive dental care use for CSHCN enrolled in Medicaid within Washington state's Access to Baby and Child Dentistry (ABCD) program. METHODS: The authors analyzed 2012 Medicaid eligibility and claims files for children younger than 6 years in the ABCD program (N = 206,488). The authors used medical diagnosis and eligibility data to identify each child's special needs status (no or yes). The outcome was preventive dental care use (no or yes). The authors used modified Poisson regression models to estimate crude and covariate-adjusted prevalence rate ratios. RESULTS: Of the 206,488 children in the study, 2.1% were CSHCN, and 114,570 used preventive dental care (55.5%). CSHCN used preventive care at rates similar to those of children without special health care needs (SHCN) (54.7% and 55.5%, respectively; P = .32). After adjustment for confounding variables, CSHCN were significantly less likely to use preventive dental care than were children without SHCN (prevalence rate ratio, 0.91; 95% confidence interval, 0.88 to 0.94; P < .001). Older preschool-aged children were significantly more likely to use preventive dental care than were younger preschool-aged children. A significantly higher proportion of preventive medical care users also used preventive dental care. CONCLUSIONS: CSHCN who were enrolled in Medicaid in Washington's ABCD program were less likely to use preventive dental care than were children without SHCN who were enrolled in Medicaid. PRACTICAL IMPLICATIONS: Future intervention research investigators should evaluate ways to improve access to preventive dental care for CSHCN. Additional strategies may be needed to improve oral health behaviors for preschool-aged CSHCN receiving Medicaid.

Information about the US racial demographic shift triggers concerns about anti-White discrimination among the prospective White "minority".

The United States is undergoing a demographic shift in which White Americans are predicted to comprise less than 50% of the US population by mid-century. The present research examines how exposure to information about this racial shift affects perceptions of the extent to which different racial groups face discrimination. In four experiments, making the growing national racial diversity salient led White Americans to predict that Whites will face increasing discrimination in the future, compared with control information. Conversely, regardless of experimental condition, Whites estimated that discrimination against various racial minority groups will decline. Explorations of several psychological mechanisms potentially underlying the effect of the racial shift information on perceived anti-White discrimination suggested a mediating role of concerns about American culture fundamentally changing. Taken together, these findings suggest that reports about the changing national demographics enhance concerns among Whites that they will be the victims of racial discrimination in the future.

Solidarity through shared disadvantage: Highlighting shared experiences of discrimination improves relations between stigmatized groups.

Intergroup relations research has largely focused on relations between members of dominant groups and members of disadvantaged groups. The small body of work examining intraminority intergroup relations, or relations between members of different disadvantaged groups, reveals that salient experiences of ingroup discrimination promote positive relations between groups that share a dimension of identity (e.g., 2 different racial minority groups) and negative relations between groups that do not share a dimension of identity (e.g., a racial minority group and a sexual minority group). In the present work, we propose that shared experiences of discrimination between groups that do not share an identity dimension can be used as a lever to facilitate positive intraminority intergroup relations. Five experiments examining relations among 4 different disadvantaged groups supported this hypothesis. Both blatant (Experiments 1 and 3) and subtle (Experiments 2, 3, and 4) connections to shared experiences of discrimination, or inducing a similarity-seeking mindset in the context of discrimination faced by one's ingroup (Experiment 5), increased support for policies benefiting the outgroup (Experiments 1, 2, and 4) and reduced intergroup bias (Experiments 3, 4, and 5). Taken together, these experiments provide converging evidence that highlighting shared experiences of discrimination can improve intergroup outcomes between stigmatized groups across dimensions of social identity. Implications of these findings for intraminority intergroup relations are discussed. (PsycINFO Database Record

On the precipice of a "majority-minority" America: perceived status threat from the racial demographic shift affects White Americans' political ideology.

The U.S. Census Bureau projects that racial minority groups will make up a majority of the U.S. national population in 2042, effectively creating a so-called majority-minority nation. In four experiments, we explored how salience of such racial demographic shifts affects White Americans' political-party leanings and expressed political ideology. Study 1 revealed that making California's majority-minority shift salient led politically unaffiliated White Americans to lean more toward the Republican Party and express greater political conservatism. Studies 2, 3a, and 3b revealed that making the changing national racial demographics salient led White Americans (regardless of political affiliation) to endorse conservative policy positions more strongly. Moreover, the results implicate group-status threat as the mechanism underlying these effects. Taken together, this work suggests that the increasing diversity of the nation may engender a widening partisan divide.

More Diverse Yet Less Tolerant? How the Increasingly Diverse Racial Landscape Affects White Americans' Racial Attitudes.

Recent Census Bureau projections indicate that racial/ethnic minorities will comprise over 50% of the U.S. population by 2042, effectively creating a so-called "majority-minority" nation. Across four experiments, we explore how presenting information about these changing racial demographics influences White Americans' racial attitudes. Results reveal that exposure to the changing demographics evokes the expression of greater explicit and implicit racial bias. Specifically, Whites exposed to the racial demographic shift information preferred interactions/settings with their own ethnic group over minority ethnic groups; expressed more negative attitudes toward Latinos, Blacks, and Asian Americans; and expressed more automatic pro-White/anti-minority bias. Perceived threat to Whites' societal status mediated the effects of the racial shift information on explicit racial attitudes. These results suggest that rather than ushering in a more tolerant future, the increasing diversity of the nation may instead yield intergroup hostility. Implications for intergroup relations and media framing of the racial shift are discussed.

Twin-arginine translocation system (tat) mutants of Salmonella are attenuated due to envelope defects, not respiratory defects.

The twin-arginine translocation system (Tat) transports folded proteins across the cytoplasmic membrane and is critical to virulence in Salmonella and other pathogens. Experimental and bioinformatic data indicate that 30 proteins are exported via Tat in Salmonella Typhimurium. However, there are no data linking specific Tat substrates with virulence. We inactivated every Tat-exported protein and determined the virulence phenotype of mutant strains. Although a tat mutant is highly attenuated, no single Tat-exported substrate accounts for this virulence phenotype. Rather, the attenuation is due primarily to envelope defects caused by failure to translocate three Tat substrates, the N-acetylmuramoyl-l-alanine amidases, AmiA and AmiC, and the cell division protein, SufI. Strikingly, neither the amiA amiC nor the sufI mutations alone conferred any virulence defect. Although AmiC and SufI have previously been localized to the divisome, the synthetic phenotypes observed are the first to suggest functional overlap. Many Tat substrates are involved in anaerobic respiration, but we show that a mutant completely deficient in anaerobic respiration retains full virulence in both the oral and systemic phases of infection. Similarly, an obligately aerobic mutant is fully virulent. These results suggest that in the classic mouse model of infection, S. Typhimurium is replicating only in aerobic environments.

Do unto others as others have done unto you?: Perceiving sexism influences women's evaluations of stigmatized racial groups.

The present research examines how making discrimination salient influences stigmatized group members' evaluations of other stigmatized groups. Specifically, three studies examine how salient sexism affects women's attitudes toward racial minorities. White women primed with sexism expressed more pro-White (relative to Black and Latino) self-report (Studies 1 and 3) and automatic (Study 2) intergroup bias, compared with White women who were not primed with sexism. Furthermore, group affirmation reduced the pro-White/antiminority bias White women expressed after exposure to sexism (Study 3), suggesting the mediating role of social identity threat. Overall, the results suggest that making discrimination salient triggers social identity threat, rather than a sense of common disadvantage, among stigmatized group members, leading to the derogation of other stigmatized groups. Implications for relations among members of different stigmatized groups are discussed.

Coalition or derogation? How perceived discrimination influences intraminority intergroup relations.

Five studies explored how perceived societal discrimination against one's own racial group influences racial minority group members' attitudes toward other racial minorities. Examining Black-Latino relations, Studies 1a and 1b showed that perceived discrimination toward oneself and one's own racial group may be positively associated with expressed closeness and common fate with another racial minority group, especially if individuals attribute past experiences of discrimination to their racial identity rather than to other social identities (Study 1b). In Studies 2-5, Asian American (Studies 2, 3, and 4) and Latino (Study 5) participants were primed with discrimination against their respective racial groups (or not) and completed measures of attitudes toward Black Americans. Participants primed with racial discrimination expressed greater positivity toward and perceived similarity with Blacks than did participants who were not primed. These results suggest, consistent with the common ingroup identity model (Gaertner & Dovidio, 2000), that salient discrimination against one's own racial group may trigger a common "disadvantaged racial minority" (ingroup) identity that engenders more positive attitudes toward and feelings of closeness toward other racial minorities.

Abdominal mysteries: pain, peritonitis, pancreatitis, pseudocyst.

The differential etiology of abdominal pain in patients on peritoneal dialysis (PD) is broad, and these patients may experience the same symptoms as those of the general population. This article provides an overview of the various types of abdominal pain in patients on PD, as well as their possible etiologies, symptoms, and treatment regimens.

Phagocytic superoxide specifically damages an extracytoplasmic target to inhibit or kill Salmonella.

BACKGROUND: The phagocytic oxidative burst is a primary effector of innate immunity that protects against bacterial infection. However, the mechanism by which reactive oxygen species (ROS) kill or inhibit bacteria is not known. It is often assumed that DNA is a primary target of oxidative damage, consistent with known effects of endogenously produced ROS in the bacterial cytoplasm. But most studies fail to distinguish between effects of host derived ROS versus damage caused by endogenous bacterial sources. We took advantage of both the ability of Salmonella enterica serovar Typhimurium to survive in macrophages and the genetic tractability of the system to test the hypothesis that phagocytic superoxide damages cytoplasmic targets including DNA. METHODOLOGY/PRINCIPAL FINDINGS: SodCI is a periplasmic Cu-Zn superoxide dismutase (SOD) that contributes to the survival of Salmonella Typhimurium in macrophages. Through competitive virulence assays, we asked if sodCI has a genetic interaction with various cytoplasmic systems. We found that SodCI acts independently of cytoplasmic SODs, SodA and SodB. In addition, SodCI acts independently of the base excision repair system and RuvAB, involved in DNA repair. Although sodCI did show genetic interaction with recA, this was apparently independent of recombination and is presumably due to the pleiotropic effects of a recA mutation. CONCLUSIONS/SIGNIFICANCE: Taken together, these results suggest that bacterial inhibition by phagocytic superoxide is primarily the result of damage to an extracytoplasmic target.

Differences in enzymatic properties allow SodCI but not SodCII to contribute to virulence in Salmonella enterica serovar Typhimurium strain 14028.

Salmonella enterica serovar Typhimurium produces two Cu/Zn cofactored periplasmic superoxide dismutases, SodCI and SodCII. While mutations in sodCI attenuate virulence eightfold, loss of SodCII does not confer a virulence phenotype, nor does it enhance the defect observed in a sodCI background. Despite this in vivo phenotype, SodCI and SodCII are expressed at similar levels in vitro during the stationary phase of growth. By exchanging the open reading frames of sodCI and sodCII, we found that SodCI contributes to virulence when placed under the control of the sodCII promoter. In contrast, SodCII does not contribute to virulence even when expressed from the sodCI promoter. Thus, the disparity in virulence phenotypes is due primarily to some physical difference between the two enzymes. In an attempt to identify the unique property of SodCI, we have tested factors that might affect enzyme activity inside a phagosome. We found no significant difference between SodCI and SodCII in their resistance to acid, resistance to hydrogen peroxide, or ability to obtain copper in a copper-limiting environment. Both enzymes are synthesized as apoenzymes in the absence of copper and can be fully remetallated when copper is added. The one striking difference that we noted is that, whereas SodCII is released normally by an osmotic shock, SodCI is "tethered" within the periplasm by an apparently noncovalent interaction. We propose that this novel property of SodCI is crucial to its ability to contribute to virulence in serovar Typhimurium.