[Should we interfere with the interleukin-6 receptor during COVID-19: What do we know?] / Inhibiteurs du récepteur de l'IL-6 dans le traitement de la COVID-19 : que savons-nous ?

COVID-19 is a viral infection with predominant respiratory tropism. In its most severe forms, the initial viral aggression leads to acute respiratory failure due to damage secondary to an exacerbated inflammatory response provoked by the activation of innate, followed by adaptive immunity. The inflammatory response may entail respiratory distress syndrome, if not multivisceral failure and death. IL-6 receptor inhibitors (Tocilizumab and Sarilumab) have been proposed as treatments. Numerous studies have provided new information, which remains heterogeneous and difficult to interpret. This review is aimed at clarifying the potential role of IL-6 receptor inhibitors in severe forms of COVID-19.

Detection of finite-frequency current moments with a dissipative resonant circuit.

We consider the measurement of higher current moments with a dissipative resonant circuit, which is coupled inductively to a mesoscopic device in the coherent regime. Information about the higher current moments is coded in the histograms of the charge on the capacitor plates of the resonant circuit. The role of dissipation is shown to be essential for the measured noise to remain finite. We also identify which combination of current correlators enters the measurement of the third moment. The results are illustrated for a quantum point contact.