[Wegener's granulomatosis of the nasal fossa]. / Granulomatosis de Wegener localizada en fosas nasales.

A 62-year-old female patient consulted for a suppurative-hemorrhagic nasal condition 18 months evolution. Exploration found granulomatous rhinitis which was producing septal perforation and histology compatible with necrotizing granulomatous vasculitis, fulfilling the diagnostic criteria for focal Wegener's granulomatosis, in view of the absence of lung and renal damage. Treatment with trimethoprim-sulfamethoxazole alone described in the medical literature as an option for this process, yielded excellent results with remission of symptoms and normalization of the exploration.

[The reactive hemophagocytic syndrome associated with infection: a study of 3 cases]. / Síndrome hemofagocítico reactivo asociado a infección: estudio de tres casos.

Reactive hemophagocytic syndrome (RHS) or hemophagocytic histiocytosis is a disease with anatomo-pathological features of systemic proliferation of non-neoplastic histiocytes, with prominent hemophagocytosis, associated to infection of other diseases. The cases of three patients afflicted with RHS are presented. 2 of them secondary to a brucellosis and the other of unknown origin. The clinical features were similar: high fever, wasting, and splenomegaly. Pancytopenia existed together with liver disfunction, CID and hyperferremia. Marrow infiltration of reactive histiocytes with important hemophagocytic phenomenon, demonstrated by aspirated and bone marrow biopsies, were observed in all cases. Studies of the immunology system were performed, showing changes in two of them. All of them fully recovered after antibiotic treatment.