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Transplant Proc ; 38(9): 2828-30, 2006 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-17112841

RESUMO

The presence of microchimerism in the peripheral blood of solid organ graft recipients has been associated with long-term solid organ acceptance, immunologic tolerance, and less aggressive immunosuppressive therapy. Molecular biology assays are among the most sensitive methods to detect microchimerism, primarily to evaluate Y chromosome sequences in females as indirect evidence of circulating male nucleated donor cells. We screened for the presence of the SRY sequence region in peripheral blood of 13 female recipients of male kidney grafts: 5 living-related and 8 deceased grafts. Only patients who received grafts from related living donors exhibited microchimerism. Five of 13 patients studied exhibited better graft outcomes, including the 4 who were positive for the SRY sequences.


Assuntos
Transplante de Rim/fisiologia , Doadores Vivos , Quimeras de Transplante , Adulto , Sequência de Bases , Cadáver , Cromossomos Humanos Y , Primers do DNA , Família , Feminino , Teste de Histocompatibilidade , Humanos , Transplante de Rim/imunologia , Masculino , Pessoa de Meia-Idade , Doadores de Tecidos
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