Designing a ventral hernia staging system.

INTRODUCTION: The absence of a standardized classification scheme for ventral hernias hinders comparisons within the literature, indirectly delaying meaningful discussions regarding technique. We aimed to generate a comprehensive staging system that stratifies patients by risk of developing wound morbidity and hernia recurrence. METHODS: Our prospective database of all ventral hernia repairs (2006-2013) was reviewed with no exclusion based on technique or prosthetic. The presence of patient comorbidities, contamination and hernia dimensions-width/location on computed topography-was evaluated to identify variables most closely associated with surgical site occurrence (SSO) and recurrence. Predicted odds ratios and relative hazards, for SSO and recurrence, respectively, were used to partition patients into stages corresponding with increasing levels of risk. RESULTS: Hernia width (OR 2.24, HR 1.73) and the presence of contamination (OR 1.81, HR 2.04) were most significantly associated with increased risk of SSO and recurrence, while hernia location and the presence of comorbidities were not. Stage I hernias are <10 cm/clean and associated with low SSO and recurrence risk. Stage II hernias are 10-20 cm/clean or <10 cm contaminated and carry an intermediate risk of SSO and recurrence. Stage III hernias are either ≥10/contaminated or any hernia ≥20 cm, and these are associated with high SSO and recurrence risk. Stages I-III carry a concordance index of 0.67 for SSO and 0.61 for recurrence. CONCLUSION: Hernia width and wound class can be used to stratify patients into stages (I-III) with increasing risk of wound morbidity and recurrence. This can be the foundation for future inclusion and exclusion criteria.

Central failures of lightweight monofilament polyester mesh causing hernia recurrence: a cautionary note.

INTRODUCTION: Uncoated, lightweight, macroporous,monofilament mesh has been shown to demonstrate improved bacterial clearance, better tissue integration,reduced foreign body response, and less chronic pain with equivalent durability for hernia repair. These findings led us to use a new lightweight monofilament polyester mesh (Parietex TCM, Covidien). Here, we report our experience with this mesh in open incisional hernia repair. METHODS: Patients undergoing incisional hernia repair with Parietex TCM were retrospectively identified within our prospectively maintained database. Patient demographics,operative characteristics, and follow-up were reviewed. Outcome parameters included 90-day wound morbidity and hernia recurrence. RESULTS: In 2011, 36 patients (mean age 56.8; mean BMI32.4 kg/m2) underwent open incisional hernia repair with retrorectus mesh placement by two surgeons (MJR, YWN) at Case Medical Center. Anterior and posterior fascial closure was achieved in all cases. Wound morbidity included seven surgical site occurrences: four superficial infections that resolved with antibiotics, one wound dehiscence requiring wet-to-dry packing, and two seromas that resolved without intervention. With a mean follow-up of 13 months, 8 (22%) recurrences have occurred. On reoperation, 7 (19%) of these patients had mechanical failure or fracturing of the mesh. No confounding variables were identified by univariate analysis of patient demographics,operative characteristics, or wound morbidity. CONCLUSION: Lightweight monofilament polyester mesh (Parietex TCM) appears to have a high incidence of mechanical failure in the context of open incisional hernia repair. While this limitation may ultimately be revealed asa weakness of all lightweight mesh, surgeons should be aware that these failures have already been documented.

The effects of Losartan on abdominal wall fascial healing.

PURPOSE: Losartan, a commonly used angiotensin II receptor blocker (ARB) for blood pressure control, also impairs cutaneous wound healing. Our current study will analyze how Losartan affects wound healing in the muscle and fascia from both biomechanical and histological aspects. METHODS: A total of 26 Sprague-Dawley rats were separated into one control group (NS, N = 13) and one experimental group (LG, N = 13) to receive normal saline and 40 mg/kg of Losartan by way of gastric lavage, respectively. 7 days later, all animals were subjected to a 5 cm midline laparotomy. The fascia and skin were then closed with 4-0 prolene and 5-0 vicryl. 15 days postoperatively, the animals were sacrificed and the abdominal wall harvested for wound tensiometric test and histological analysis. RESULTS: All 26 rats survived to the time of necropsy. Tensiometry detected significantly higher wound tensile strength in the NS group (1.6 ± 0.31 N/mm) than in the LG (1.3 ± 0.28 N/mm) group (p = 0.016). Transection histology with trichrome staining demonstrated higher degree of immature fibroplasia inside the wound in the LG group than in the NS group (p = <0.0001). The LG group also had larger incisional gaps than the NG group. CONCLUSION: The antihypertensive drug, Losartan, retards wound healing in the abdominal fascia and reduces wound tensile strength in our rat model. Attention should be paid to the potential effects of various medications on fascial wound healing to guarantee optimal surgical outcomes.

The impact of developing a comprehensive hernia center on the referral patterns and complexity of hernia care.

BACKGROUND: Complex hernia repairs represent a formidable surgical challenge. Several comprehensive hernia centers, including ours, with advanced expertise have recently emerged across the country. However, the effects of tertiary specialization remain largely unclear. We aimed to evaluate the impact of developing a comprehensive hernia center on the referral patterns and costs of patients with complex hernias. METHODS: A prospectively maintained database was used to identify all patients undergoing open ventral hernia repair (VHR) between 2006 and 2013 at the Case Comprehensive Hernia Center. Patients were separated into two groups by zip code: those traveling either <25 or >100 miles. Demographics, operative characteristics, length of stay and costs data were analyzed. RESULTS: Of all patients who underwent open VHR during the study period, 287 met the inclusion criteria. Hernia length, width and area were all significantly larger for patients traveling >100 miles (P < 0.01 for all). These patients were also more likely to have active mesh infections (OR 3.57) and non-healing wounds (OR 5.00) when compared with local patients. Length of hospital stay was significantly longer for patients traveling >100 miles compared to those traveling <25 miles (9.7 vs. 6.8; P < 0.0001). Surgical site occurrence, infection and hernia recurrence rates were similar between the two groups during the follow-up period. Patients who traveled >100 miles incurred significantly higher fixed direct and variable direct costs compared to those who traveled <25 miles (P < 0.05 for both). CONCLUSION: The development of a comprehensive hernia center results in centralization of complex hernia care. Patients traveling >100 miles for ventral hernia repair have significantly larger and more complex hernias. The implications for improved patient outcomes and potential reimbursement issues for providing this care should be carefully evaluated.