RESUMO
In this study, we have determined the beta-endorphin concentrations in the plasma of 11 cases during the first 3 months of pregnancy, as well as the corresponding products of conception, collected by hysterosuction, during the course of voluntary abortion. The purpose of this study is to compare the values obtained by the analysis of maternal plasma and the material collected by hysterosuction. The beta-endorphin concentrations were obtained by radioimmunologic methods using a kit which allows a separation from beta-lipotropin. The specimens obtained by hysterosuction (8 +/- 1.7 pmol/l) showed significantly higher levels of beta-endorphin than those observed in the maternal plasma (2.6 +/- 0.3 pmol/l). Thus, already in the earliest gestational period, the data are consistent with a feto-placental origin for this opioid peptide.
Assuntos
Sangue Fetal/metabolismo , Troca Materno-Fetal , Gravidez/sangue , beta-Endorfina/sangue , Aborto Induzido , Adulto , Líquido Amniótico/metabolismo , Feminino , Humanos , Primeiro Trimestre da Gravidez , Valores de ReferênciaAssuntos
Coagulação Sanguínea/efeitos dos fármacos , Anticoncepcionais Orais Combinados/farmacologia , Anticoncepcionais Orais Hormonais/farmacologia , Tromboembolia/induzido quimicamente , Adulto , Anticoncepcionais Orais Combinados/efeitos adversos , Anticoncepcionais Orais Hormonais/efeitos adversos , Desogestrel , Combinação de Medicamentos , Etinilestradiol/efeitos adversos , Etinilestradiol/farmacologia , Feminino , Humanos , Norpregnenos/efeitos adversos , Norpregnenos/farmacologia , Congêneres da Progesterona/efeitos adversos , Congêneres da Progesterona/farmacologia , Fatores de RiscoAssuntos
Neoplasias Uterinas/patologia , Adulto , Idoso , Endoscopia , Feminino , Humanos , Pessoa de Meia-Idade , Neoplasias Uterinas/epidemiologiaRESUMO
PIP: The direct view of the uterine cavity offered by hysteroscopy can provide valuable information about the position of an IUD, its condition, and its relationship with other formations, thereby facilitating its removal. The diagnostic and therapeutic reliability of this technique was analyzed in 8 women with occult IUDs. Involved were 3 Nova T IUDs, 2 Gravigards, 2 Minigravigards, and 1 Progestasert device. 1 patient had undergone unsuccessful curettage for removal of the IUD; none of the other women had experienced any surgical manipulation prior to the hysteroscopy. The surgery consisted of 4 steps: 1) distention of the uterine cavity by insufflation of carbon dioxide, 2) hysteroscopic location of the IUD, 3) sighted grasping of the IUD or IUD segment with forceps, and 4) removal of the device together with the hysteroscope under dynamic vision. Hysteroscopic location and removal were successful in all 8 patients, with no complications. Hysteroscopy is thus recommended as an alternative retrieval technique, especially in cases when it is necessary to assess the deterioration and possible myometrial penetration of the IUD or the inflammation of the uterine cavity.^ieng
