1.
Angew Chem Int Ed Engl
; 62(1): e202214069, 2023 Jan 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36259458
RESUMO
Easily accessible via a simple esterification of alcohols with formic acid, alkyl formates are used as a novel class of transfer hydroalkylation reagents, CO2 acting as a traceless linker. As a proof-of-concept, their reactivity in the transfer hydroalkylation of imines is investigated, using a ruthenium-based catalyst and LiI as promoter to cleave the C-O σ-bond of the formate scaffold. Providing tertiary amines, the reaction displays a divergent regioselectivity compared to previously reported transfer hydroalkylation strategies.