RESUMO
The objective of this systematic review was to find sufficient evidence to deny or accept the association between the head and cervical posture and temporomandibular disorders (TMDs), and thus assist health professionals in the evaluation and treatment of patients with TMDs. A search was conducted through all publications written in English about this topic using the databases from Medline, ISI Web of Science, EMBASE, PubMed and Lilacs. The abstracts that fulfilled the initial guideline were retrieved and evaluated to ensure they met the inclusion criteria. To assess the methodological quality of the studies, we developed a questionnaire considering the following criteria: participant's eligibility, control group, diagnosis of TMDs, posture diagnosis and randomisation. Twenty-two studies were selected as potential studies based on their abstracts. Only seventeen studies actually fulfilled the inclusion criteria. The search provided information about the methodological quality of the studies, in which several methodological defects were found. The evidence presented in this systematic review shows that the relation between TMDs and the head and neck posture is still controversial and unclear. The insufficient number of articles considered of excellent methodological quality is a factor that hinders the acceptance or denial of this association.
Assuntos
Vértebras Cervicais , Cabeça , Pescoço , Postura , Síndrome da Disfunção da Articulação Temporomandibular/etiologia , Humanos , Ensaios Clínicos Controlados Aleatórios como AssuntoRESUMO
Due to the profuse connections of the cerebellum to the rest of the central nervous system, cerebellar dysfunction impacts tremendously on movement coordination, maintenance of equilibrium, muscle tone and motor memory. Efficient gene transfer of therapeutic genes to this central nervous system structure would constitute a relevant step ahead the design of treatments to ameliorate cerebellar dysfunction. Lentiviral vectors (LVs) have been used as efficient vehicles to integrate transgenes into dividing and non-dividing cells, such as postmitotic adult neurons, with minimal toxicity and immune response. This study aimed to use LVs carrying green fluorescent protein (GFP) cDNA for transduction of cerebellar cells in vivo without compromising neurological cerebellar functions. Our results indicate that LVs, injected in the lobulus simplex, transduced different cerebellar neurons including stellate, Purkinje cells, granular neurons and glial cells such as astrocytes, oligodendrocytes, and that this gene transfer approach was not accompanied by cerebellar deficits.
Assuntos
Cerebelo/fisiologia , Terapia Genética/métodos , Lentivirus/genética , Neuroglia/fisiologia , Neurônios/fisiologia , Transdução Genética , Animais , Cerebelo/virologia , Citomegalovirus/genética , Citometria de Fluxo , Vetores Genéticos , Proteínas de Fluorescência Verde/genética , HIV/genética , Humanos , Camundongos , Camundongos Endogâmicos C57BL , Neuroglia/virologia , Neurônios/virologia , Regiões Promotoras GenéticasAssuntos
Gastroscopia/veterinária , Doenças dos Cavalos/diagnóstico , Cavalos/fisiologia , Condicionamento Físico Animal , Envelhecimento , Animais , Feminino , Gastroscopia/métodos , Doenças dos Cavalos/tratamento farmacológico , Doenças dos Cavalos/epidemiologia , Incidência , Itália/epidemiologia , Masculino , Esteroides/uso terapêutico , Úlcera Gástrica/diagnóstico , Úlcera Gástrica/tratamento farmacológico , Úlcera Gástrica/epidemiologia , Úlcera Gástrica/veterináriaAssuntos
Eletrocardiografia Ambulatorial/veterinária , Teste de Esforço/veterinária , Condicionamento Físico Animal , Animais , Equipamentos Descartáveis/veterinária , Eletrocardiografia Ambulatorial/instrumentação , Eletrocardiografia Ambulatorial/métodos , Teste de Esforço/métodos , Cavalos , Monitorização Fisiológica/métodos , Monitorização Fisiológica/veterináriaRESUMO
The severity of the erosive and ulcerative lesions of the squamous gastric mucosa in 10 standardbred racehorses in training was classified according to a standard scoring system. Each horse was then treated orally for 30 days with 50 g/100 kg bodyweight daily of a pectin-lecithin complex mixed into the feed. At the end of the period of treatment, the gastric lesions were re-evaluated gastroscopically and the scores were compared with those assigned at the previous evaluation. In three of the horses the gastric ulcerations had healed completely, and in six others the lesions had improved significantly.
Assuntos
Doenças dos Cavalos/tratamento farmacológico , Pectinas/uso terapêutico , Fosfatidilcolinas/uso terapêutico , Úlcera Gástrica/tratamento farmacológico , Úlcera Gástrica/veterinária , Animais , Feminino , Doenças dos Cavalos/patologia , Cavalos , Masculino , Esforço Físico , Estômago/patologia , Úlcera Gástrica/patologiaRESUMO
The aim of this paper was to evaluate an acute dose of gamma-rays (10 Gy) on post-dormant garlic seed cloves in terms of total DNA, total RNA, total protein and soluble carbohydrates in order to correlate these levels with sprouting inhibition induced by gamma-irradiation. Decreases in total DNA content were found in inner sprouts immediately and 100 days after irradiation. The total RNA and protein contents and the carbohydrate content of the storage leaf or the inner sprout were not affected by gamma-irradiation. The results support the notion that in post-dormant garlic seed cloves, DNA content and its behaviour seem to be among the sensitive cellular responses to radiation.
Assuntos
Alho/efeitos da radiação , Plantas Medicinais , Carboidratos/química , Conservação de Alimentos/métodos , Raios gama , Alho/crescimento & desenvolvimento , Ácidos Nucleicos/química , Proteínas/química , Fatores de TempoRESUMO
The effects of an acute dose of gamma-rays (10 Gy) to post-dormant garlic cloves on inner sprout growth and changes in peroxidases and soluble proteins were evaluated up to 100 days of storage in darkness at 19 +/- 1 degree C and 42 +/- 2% relative humidity. Radiation-induced inhibition of sprout growth became evident after 25 days of treatment and was synchronous with a marked increase in peroxidase activity. Thin-layer isoelectric focusing revealed that radiation induced an increase in the number of anodic peroxidase isoenzymes at 100 days, suggesting modifications in the vascularization process. Neither the soluble protein content nor the protein pattern were affected by irradiation. These results are discussed in terms of a possible mediating effect of peroxidase on radiation-induced sprout inhibition in garlic.