Sex differences in disease severity among patients with systemic lupus erythematosus.

BACKGROUND: Systemic lupus erythematosus (SLE), a prototypical autoimmune disease, often results in comorbidities from exposure to medications as well as from chronic inflammation. Identification of gender-based differences in comorbidities and disease severity may assist health practitioners in providing optimum care for those living with SLE. OBJECTIVE: The purpose of this study, which utilized hospital discharge data collected during a 7-year period to garner a large SLE patient sample, was to determine the effect of gender on SLE comorbidities and disease severity. METHODS: Patients were hospitalized in the Dallas-Fort Worth metropolitan statistical area between 1999 and 2005 and had a diagnosis of SLE. The sample consisted of 14,829 patients with SLE, 10% of which were male. ANOVAs were conducted to test for differences between males and females for disease severity, age, length of stay in the hospital, total hospital charges, and number of autoimmune diseases. Disease severity was measured with the SLE comorbidity index, which weights 14 conditions in SLE. We identified the top 30 comorbidities as well as the odds of experiencing the secondary illnesses by gender. RESULTS: Male patients had significantly greater disease severity compared with female patients. Additionally, female patients had more autoimmune diagnoses compared with male patients. Male patients were more likely to have cardiovascular and renal comorbidities compared with female patients. Female patients had significantly greater odds of diagnoses of urinary tract infection, hypothyroidism, depression, esophageal reflux, asthma, and fibromyalgia. CONCLUSIONS: Although the prevalence of SLE among males is rare, male patients have the potential for greater disease severity and are more likely to suffer from cardiovascular and renal disease. Gender differences in disease severity should be further evaluated, but with the added recommendation to develop an index with conditions more indicative of active SLE.

Acculturation in Hispanics and childhood poisoning: are medicines and household cleaners stored properly?

BACKGROUND: Unintentional poisonings are a major public health issue in the United States (US). With the increasing number of Hispanics in the US, childhood poisoning is a salient public health issue to address within this population. There is a paucity of research examining the relationship between acculturation in Hispanics and the safe storage of medicines and cleaners. The purpose of the study was to determine if demographic variables, such as acculturation in Hispanics, age, gender and education, were predictive of incorrectly storing medicines and household cleaners. METHODS: We conducted a study among parents/guardians of small children at two pediatric primary care clinics in the Dallas/Fort Worth (DFW) Metropolitan area. We enrolled 201 parents to identify where they stored medicines and household cleaners, and measured acculturation with the Short Acculturation Scale for Hispanics. RESULTS: Of Hispanic participants, 49% were categorized as less acculturated (n = 99) while 21% were more acculturated (n = 42). Less acculturated participants were over 4 times more likely to store medicines incorrectly, and participants with a high school education or less were over 3 times more likely to improperly store cleaners. With each additional child in the household, the risk for improper storage of cleaners increased by 44%. CONCLUSION: The fact that children of less acculturated families are at greater risk for poisoning and have lower levels of education demonstrates the need for readable educational materials on this salient topic. Because social networks are integral in Hispanic culture, especially among new immigrants, poison prevention messages should be disseminated by interpersonal communications.

The impact of race and ethnicity on disease severity in systemic lupus erythematosus.

OBJECTIVES: Systemic lupus erythematosus (SLE) can result in comorbidities and high disease severity. The aim of this study was to evaluate the effects of age, sex, race, ethnicity, cost of hospitalization, length of stay, and payor source on SLE disease severity scores. DESIGN: Epidemiological study. SETTING: Hospital discharge data were obtained from the DFW Hospital Council (DFWHC), for 65,535 patients hospitalized in the North Texas Dallas-Fort Worth (DFW) Metropolitan Statistical Area (MSA) from 1999-2005 with at least one autoimmune disease. PATIENTS: Of the 65,535 autoimmune patients, 14,829 patients had SLE as a diagnosis. The sample was assessed for disease severity according to the SLE comorbidity Index. MAIN OUTCOME: Disease severity, SLE comorbidities. RESULTS: SLE patients were younger and more than five times more likely to have multiple autoimmune diseases. More than one third of Hispanic patients were on Medicaid or self-pay and more likely to have higher disease severity. Race (Caucasian), sex (female), and payor source (PPO/POS) predicted lower disease severity scores. SLE was predictive of eight of the fourteen SLE-CI diseases, with greatest effects observed for nephritis (OR = 3.30, P < .0001), chronic renal failure (OR = 3.36, P < .0001), pericarditis (OR = 3.2, P < .0001), and pleuritis (OR = 2.06, P < .0001). Non-Caucasian patients were more likely to have chronic renal failure, nephritis, congestive heart failure, pericarditis and pleuritis. CONCLUSIONS: The comorbidities that exist in SLE vary according to ethnicity. It is paramount for physicians to be cognizant of these disparities and make appropriate referrals.