RESUMO
A prospective, randomized clinical trial was conducted to compare an intra-articular with an extra-articular reconstruction of the anterior cruciate ligament. Isokinetic muscle testing was carried out 6 months to 2 years following operation using the Biodex isokinetic dynamometer. The extra-articular procedure resulted in a lower deficit for the peak quadriceps and hamstring torques and the range of motion.
Assuntos
Ligamento Cruzado Anterior/cirurgia , Articulação do Joelho/fisiopatologia , Músculo Esquelético/fisiopatologia , Tendões/transplante , Adulto , Ligamento Cruzado Anterior/fisiopatologia , Feminino , Seguimentos , Humanos , Masculino , Estudos Prospectivos , Resultado do TratamentoRESUMO
Pseudoachondroplasia (PSACH) is a well characterized dwarfing condition mapping to chromosome 19p12-13.1. Cartilage oligomeric matrix protein (COMP), a cartilage specific protein, maps to the same location within a contig that spans the PSACH locus. Using single strand conformation polymorphism (SSCP) analysis and nucleotide sequencing we have identified COMP mutations in eight familial and isolated PSACH cases. All mutations involve either a single base-pair change or a three base-pair deletion in exon 17B. Six mutations delete or change a well conserved aspartic acid residue within the calcium-binding type 3 repeats. These results demonstrate that mutations in the COMP gene cause pseudochondroplasia.
Assuntos
Acondroplasia/genética , Proteínas da Matriz Extracelular , Glicoproteínas/genética , Mutação , Sequência de Bases , Cartilagem/metabolismo , Proteína de Matriz Oligomérica de Cartilagem , Mapeamento Cromossômico , Cromossomos Humanos Par 19 , Primers do DNA/genética , Éxons , Feminino , Humanos , Hibridização in Situ Fluorescente , Masculino , Proteínas Matrilinas , Dados de Sequência Molecular , Linhagem , Mutação Puntual , Polimorfismo Conformacional de Fita Simples , Deleção de SequênciaAssuntos
Educação Continuada , Bacharelado em Enfermagem , Reeducação Profissional , Humanos , TexasRESUMO
Twelve patients had urine cultures positive for Coccidioides immitis. Ten patients showed the usual criteria for dissemination, but 2 were believed, before urine culture, to have only chronic pulmonary involvement. In 8 patients, there was impairment of host defense mechanisms due either to associated disease or immunosuppressive drug therapy. Only 2 of 11 patients tested reacted to coccidioidin skin-test antigen. Colony counts of C. immitis in the first voided morning urine spacimens ranged from 0.03/ml to 17/ml. With prostatic involvement, colony counts in the expressed secretions ranged from 15/ml to 120/ml. The site of urinary tract coccidioidomycosis, which could be adduced in 9 patients, was the upper tract in 1, lower tract in 6, and in both upper and lower tracts in 2. In patients with lower tract infection, the prostate was involved in 4 and the epididymis in 2.
Assuntos
Coccidioides , Coccidioidomicose/diagnóstico , Infecções Urinárias/diagnóstico , Urina/microbiologia , Adulto , Coccidioides/isolamento & purificação , Coccidioidomicose/imunologia , Testes de Fixação de Complemento , Humanos , Terapia de Imunossupressão/efeitos adversos , Masculino , Pessoa de Meia-Idade , Prostatite/diagnóstico , Testes Cutâneos , Infecções Urinárias/imunologia , Urina/citologiaRESUMO
Rifampin was shown in vitro to decrease the amphotericin B minimal inhibitory concentrations of all of 10 strains of Coccidioides immitis tested. These decreases ranged from two- to fourfold and occurred with rifampin concentrations of 10 to 40 mug/ml. Rifampin alone was without effect.
