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No disponible
Assuntos
Humanos , Poluição Ambiental , Neoplasias Pulmonares , Poluição do Ar , Nicotiana , CarcinógenosRESUMO
BACKGROUND: Serum angiotensin-converting enzyme (ACE) activity has been related to sarcoidosis and other granulomatous diseases. It has been demonstrated that serum ACE activity is influenced by ACE gene I/D polymorphism. The aim of this study was to establish ACE activity reference values according to genotype in a Spanish population to improve diagnostic sensitivity and treatment monitoring in sarcoidosis patients. METHODS: A sample population of 150 blood donors was included in the study. Serum ACE activity and genotype were determined and the reference intervals, defined as the 95% central range of the population (2.5th-97.5th percentiles) were obtained for all three genotypes (DD, DI, II) and for the entire sample. RESULTS: Genotype frequencies were 37% DD (n=54), 43% DI (n=63), and 20% II (n=30). Individuals with DD genotype showed the highest ACE activity (mean 39.0 U/L, SD 13.6), ID genotype showed intermediate levels (mean 29.5 U/L, SD 10.2) and II genotype lowest levels (mean 19.1 U/L, SD 4.9). ACE activity differed significantly between these groups: F (2144)=33.15, p<0.05. The corresponding reference intervals for ACE activity were 13.3-63.9 U/L in the overall sample, 12.3-65.6 U/L in genotype DD, 9.5-49.5 U/L in DI and 9.6-28.7 in II. CONCLUSIONS: The preliminary reference values for ACE activity in healthy Spanish individuals according to I/D polymorphism are presented. Significant differences in these values were found between the genotype groups.
Assuntos
Peptidil Dipeptidase A/sangue , Peptidil Dipeptidase A/genética , Polimorfismo Genético , População Branca/genética , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Peptidil Dipeptidase A/metabolismo , Valores de Referência , Espanha , Adulto JovemRESUMO
Objetivos Las emisiones de alérgeno durante la descarga de haba de soja en el puerto de Barcelona han sido causa de asma epidémica. Este trabajo describe las acciones de vigilancia y control de los servicios de salud pública. Métodos Los datos se extraen del dispositivo de control durante el periodo de 1999 a 2009, detallando el sistema de vigilancia de emisiones y concentraciones ambientales de alérgeno (para las que se han fijado empíricamente niveles guía), y de salud. Resultados De los 95 estudios de emisión, cuatro superaron los valores de alarma, con probables causas en los filtros. Las concentraciones ambientales medias son bajas, pero superaron el nivel de alarma 13 días; se relacionan con meteorología adversa e incidencias en las instalaciones. No se detectaron efectos en los pacientes del panel de vigilancia, ni días de asma epidémica (AU)
Objectives Allergen emissions during soybean unloading operations in the Barcelona harbor have caused asthma epidemics. The present article aimed to describe the surveillance and control measures carried out by the public health services. Methods Data were extracted from control systems from 1999 to 2009, with description of the surveillance schemes for allergen emissions, environmental concentrations (with defined reference levels) and for health. Results Of 95 studies of plant emission, four were above the reference levels, and filters were found to be the most likely cause. Mean environmental concentrations were low but were above the reference levels on 13 days; these levels were related to adverse meteorological conditions and incidents in the plants. No health effects were detected in the panel of patients nor epidemic asthma days. Conclusions The system detects incidents and has shown its usefulness in protecting public health (AU)
Assuntos
Humanos , Asma/etiologia , Glycine max/efeitos adversos , Antígenos de Plantas/efeitos adversos , Exposição Ambiental/prevenção & controle , Monitoramento Ambiental/normasRESUMO
ObjetivosEntre 2007 y 2008 se descargaron 215.000 toneladas de cascarilla de soja en el puerto de Tarragona. En la cascarilla se encuentra la proteína causante de las epidemias de asma bronquial. Los objetivos de este estudio fueron estudiar las características de las descargas, la dispersión del alergeno y el riesgo para la población.MétodosSe recogió información sobre el proceso de descarga, transporte y almacenaje, la meteorología y los casos de asma atendidos en urgencias hospitalarias. Se midió la concentración de alergeno en los filtros de PM10 de las estaciones de vigilancia de la contaminación atmosférica. En los pacientes sensibilizados se realizó un estudio clínico consistente en pruebas cutáneas, IgE sérica total y específica para soja, e inmunoblotting.ResultadosSe encontraron concentraciones moderadas de alergeno a un kilómetro del punto de descarga (3 días por encima de 300U/m3, máximo 441U/m3). El perfil proteico de los extractos de cascarilla es similar al de las muestras de las epidemias de Barcelona. El 92% de los pacientes estudiados son sensibles a los extractos de cascarilla. No hubo ninguna epidemia de asma durante los días de descarga. Además de las proteínas de bajo peso molecular identificadas en estudios anteriores (6 y 1417kDa), se han encontrado proteínas de mayor peso molecular (1449kDa).ConclusionesExiste dispersión del alergeno a corta distancia del lugar de la descarga y riesgo para la población que continúa sensibilizada. Han de adoptarse medidas durante las descargas para reducir al mínimo la emisión de partículas
ObjectivesFrom 2007 to 2008, 215,000 tons of soybean hull were unloaded in the Port of Tarragona. Soybean hull was identified as the etiologic agent causing bronchial asthma outbreaks. The aim of the present study was to identify the characteristics of soybean unloading, soybean allergen dispersion, and the population risk.MethodsData on soybean hull unloading, carriage and storage, meteorological conditions and the number of emergency room admissions for asthma were recorded. Allergen concentrations were obtained by sampling PM10 filters retaining particles of less than 10 microns for 24 hours in the atmospheric contamination surveillance stations. Sensitized patients underwent clinical examination consisting of skin prick test, total and specific IgE and immunoblotting to soybean extracts.ResultsAllergen emissions were moderate at one kilometer from the unloading source (above 300U/m3 on 3 days, maximum 441U/m3). The protein pattern of hull soybean extracts was similar to that found in asthma epidemics in Barcelona. Ninety-two percent of the patients were sensitized to soybean hull extracts. No asthma epidemic was detected during unloading days. In addition to the low molecular weight soybean proteins identified in previous studies (6 and 1417kDa), high molecular weight proteins were found (1449kDa).ConclusionsThere is allergen dispersion at a short distance from the unloading source, posing a risk to sensitized patients. Technical measures are required during soybean hull operations to reduce particle emissions(AU)
