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1.
Circulation ; 135(19): e1017-e1034, 2017 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-27550974

RESUMO

BACKGROUND: Poor lifestyle behaviors are leading causes of preventable diseases globally. Added sugars contribute to a diet that is energy dense but nutrient poor and increase risk of developing obesity, cardiovascular disease, hypertension, obesity-related cancers, and dental caries. METHODS AND RESULTS: For this American Heart Association scientific statement, the writing group reviewed and graded the current scientific evidence for studies examining the cardiovascular health effects of added sugars on children. The available literature was subdivided into 5 broad subareas: effects on blood pressure, lipids, insulin resistance and diabetes mellitus, nonalcoholic fatty liver disease, and obesity. CONCLUSIONS: Associations between added sugars and increased cardiovascular disease risk factors among US children are present at levels far below current consumption levels. Strong evidence supports the association of added sugars with increased cardiovascular disease risk in children through increased energy intake, increased adiposity, and dyslipidemia. The committee found that it is reasonable to recommend that children consume ≤25 g (100 cal or ≈6 teaspoons) of added sugars per day and to avoid added sugars for children <2 years of age. Although added sugars most likely can be safely consumed in low amounts as part of a healthy diet, few children achieve such levels, making this an important public health target.


Assuntos
American Heart Association , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/prevenção & controle , Sacarose Alimentar/efeitos adversos , Comportamento de Redução do Risco , Criança , Cárie Dentária/epidemiologia , Cárie Dentária/prevenção & controle , Diabetes Mellitus/epidemiologia , Diabetes Mellitus/prevenção & controle , Sacarose Alimentar/administração & dosagem , Ingestão de Energia/fisiologia , Comportamento Alimentar/fisiologia , Humanos , Hipertensão/epidemiologia , Hipertensão/prevenção & controle , Resistência à Insulina/fisiologia , Obesidade/epidemiologia , Obesidade/prevenção & controle , Fatores de Risco , Estados Unidos/epidemiologia
2.
Lipids Health Dis ; 14: 39, 2015 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-25925168

RESUMO

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) has emerged as the major pediatric chronic liver disease, and it is estimated to affect more than one third of obese children in the U.S. Cardiovascular complications are a leading cause of increased mortality in adults with NAFLD and many adolescents with NAFLD already manifest signs of subclinical atherosclerosis including increased carotid intima-media thickness. METHODS: Volume of intrahepatic fat was assessed in 50 Hispanic-American, overweight adolescents, using Magnetic Resonance Spectroscopy. Lipoprotein compositions were measured using Nuclear Magnetic Resonance. RESULTS: Plasma triglycerides (TG) (p=0.003), TG/HDL ratio (p=0.006), TG/apoB ratio (p=0.011), large VLDL concentration (p=0.019), VLDL particle size (p=0.012), as well as small dense LDL concentration (p=0.026) progressively increased across higher levels of hepatic fat severity, while large HDL concentration progressively declined (p=0.043). This pattern of associations remained even after controlling for gender, BMI, visceral fat, and insulin resistance. CONCLUSIONS: Our findings suggest that increased hepatic fat is strongly associated with peripheral dyslipidemia and the amount of fat in the liver may influence cardiovascular risk. Further studies are needed to longitudinally monitor dyslipidemia in children with NAFLD and to examine whether the reduction of hepatic fat would attenuate their long-term CVD risk.


Assuntos
Doenças Cardiovasculares/etiologia , Gorduras/análise , Hispânico ou Latino/estatística & dados numéricos , Resistência à Insulina , Fígado/química , Adolescente , Apolipoproteínas B/sangue , HDL-Colesterol/sangue , LDL-Colesterol/sangue , VLDL-Colesterol/sangue , Estudos Transversais , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Hepatopatia Gordurosa não Alcoólica/complicações , Triglicerídeos/sangue
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