Subretinal abscess due to Candida tropicalis in a patient with acute myeloid leukaemia: Case report.

A 54-year-old female patient with a history of acute myeloid leukaemia and receiving maintenance chemotherapy had a systemic relapse. She also had candidaemia caused by Candida tropicalis. Her blood cultures were negative after receiving antifungal treatment. Later, she had an ophthalmological assessment as part of the protocol, without ocular discomfort. In the fundoscopic examination, a whitish chorioretinal lesion was found in the left eye in relation to subretinal abscess, which correlated with retinal angiography and optical coherence tomography. The patient was treated with systemic antifungals with a favourable resolution of the lesion.

Absceso subretinal por Candida tropicalis en un paciente con leucemia mieloide: reporte de caso / Subretinal abscess due to Candida tropicalis in a patient with acute myeloid leukaemia: case report

Paciente mujer de 54 años con historia de leucemia mieloide aguda, bajo quimioterapia de mantenimiento, cursa con recaída sistémica y candidemia por Candida tropicalis (C. tropicalis), tratada con antifúngico, con respuesta favorable es referida a oftalmológica como parte de protocolo. El examen fundoscópico en ojo izquierdo halló una lesión blanquecina, coriorretiniana en el cuadrante súpero temporal. Los exámenes de angiografía retinal y tomografía de coherencia óptica correlacionaron con absceso subretinal. La paciente fue tratada con antifúngicos sistémicos con resolución favorable de la lesión. Los abscesos subretinianos son una rara manifestación intraocular por C. tropicalis, este organismo es potencial agente causal de afección ocular en presencia de antecedente sistémico de inmunosupresión y factores de riesgo asociados.

A 54-year-old female patient with a history of acute myeloid leukaemia and receiving maintenance chemotherapy had a systemic relapse. She also had candidaemia caused by Candida tropicalis. Her blood cultures were negative after receiving antifungal treatment. Later, she had an ophthalmological assessment as part of the protocol, without ocular discomfort. In the fundoscopic examination, a whitish chorioretinal lesion was found in the left eye in relation to subretinal abscess, which correlated with retinal angiography and optical coherence tomography. The patient was treated with systemic antifungals with a favourable resolution of the lesion.

Subretinal abscess due to Candida tropicalis in a patient with acute myeloid leukaemia: case report. / Absceso subretinal por Candida tropicalis en un paciente con leucemia mieloide: reporte de caso.

A 54-year-old female patient with a history of acute myeloid leukaemia and receiving maintenance chemotherapy had a systemic relapse. She also had candidaemia caused by Candida tropicalis. Her blood cultures were negative after receiving antifungal treatment. Later, she had an ophthalmological assessment as part of the protocol, without ocular discomfort. In the fundoscopic examination, a whitish chorioretinal lesion was found in the left eye in relation to subretinal abscess, which correlated with retinal angiography and optical coherence tomography. The patient was treated with systemic antifungals with a favourable resolution of the lesion.

Orbital metastasis diagnosed by ultrasound-guided fine-needle aspiration biopsy: Case report of unknown primary site. / Metástasis de la órbita diagnosticada por biopsia por aspiración con aguja fina guiada por ultrasonido: reporte de caso de sitio primario desconocido.

Twenty five percent of orbital metastasis is usually of unknown primary origin and it requires histopathological and immunohistochemical confirmation. The fine-needle aspiration biopsy of the orbit is an alternative procedure to conventional orbitotomy. The case is presented of a 60 year-old woman with a right orbit tumour mass and neoplastic lesions in her brain and cranium. As an incidental finding, she had a thrombus in her left atrium, and so an orbitotomy procedure was ruled out. An ultrasound-guided fine-needle aspiration biopsy was performed instead with rapid on-site evaluation of biopsy samples. These showed malignant cells of a lung adenocarcinoma, which was confirmed with immunohistochemistry and chest diagnostic images. In conclusion, biopsy samples obtained by fine-needle aspiration biopsy, together with cytopathological and immunohistological analysis, enabled orbital metastasis to be identified in the case described, and showed that fine-needle aspiration biopsy is a safe, effective, and minimally invasive alternative.

Interferón alfa-2a como tratamiento alternativo para el carcinoma conjuntival de células escamosas / Interferon alpha-2a as alternative treatment for conjunctival squamous cell carcinoma

Caso clínico: Paciente varón de 35 años con antecedente de infección por VIH, caracterizado por tumoración de crecimiento progresivo en conjuntiva bulbar de ojo izquierdo correspondiente a un carcinoma conjuntival de células escamosas que responde a tratamiento con interferón alfa-2a. Discusión: A nivel conjuntival, el interferón alfa-2b tópico ha sido utilizado como tratamiento inmunomodulador, con el que se observó remisión completa de las neoplasias epiteliales; sin embargo, no se ha publicado el uso del interferón alfa-2a para el tratamiento de carcinoma conjuntival de células escamosas, el cual difiere del intererón alfa-2b en un solo aminoácido (AU)

Case report: A 35 year-old male patient with a history of HIV infection characterized by progressive tumour growth in bulbar conjunctiva of the left eye, corresponding to conjunctival squamous cell carcinoma that responded to treatment with interferon alpha-2a. Discussion: Interferon alpha-2b has been used at conjunctival level as a topical immunomodulator treatment, with complete remission of epithelial neoplasms being observed. However, there have not been any previous publications on the use of interferon alpha-2a, which differs from interferon alpha-2b in a single amino acid, for the treatment of conjunctival squamous cell carcinoma (AU)

Interferon alpha-2a as alternative treatment for conjunctival squamous cell carcinoma. / Interferón alfa-2a como tratamiento alternativo para el carcinoma conjuntival de células escamosas.

CASE REPORT: A 35 year-old male patient with a history of HIV infection characterized by progressive tumour growth in bulbar conjunctiva of the left eye, corresponding to conjunctival squamous cell carcinoma that responded to treatment with interferon alpha-2a. DISCUSSION: Interferon alpha-2b has been used at conjunctival level as a topical immunomodulator treatment, with complete remission of epithelial neoplasms being observed. However, there have not been any previous publications on the use of interferon alpha-2a, which differs from interferon alpha-2b in a single amino acid, for the treatment of conjunctival squamous cell carcinoma.

Resolución espontánea del desprendimiento macular asociado a anomalías congénitas del nervio óptico: coloboma del disco óptico y foseta papilar / Spontaneous resolution of macular detachment associated with congenital anomalies of the optic nerve: Coloboma and optic disc pit

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