1.
Bioorg Med Chem Lett
; 15(21): 4662-5, 2005 Nov 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16153844
RESUMO
Putative metabolites of an AMPA antagonist imidazo-2,3-benzodiazepine (2) were synthesized and compared to constituents formed from the parent compound by a rat liver perfusion method. As metabolic transformations, hydroxylation of the 2-methyl group and N-acetylation of the amino functionality in parent compound (2) were registered. The hydroxylated analogue 12 of 2 exhibits a weak AMPA antagonist activity.