RESUMO
The literature reports an increasing occurrence of carcinoma in the young adult nonsmoking and nondrinking population. With it, this trend brings the potential for new comorbidities. This report discusses one such case in which a 30-year-old woman, 28 weeks pregnant, was diagnosed with a hybrid verrucous carcinoma/squamous cell carcinoma. Several years preceding the presentation of the hybrid lesion, the patient had an odontogenic cyst associated with the same region. The original lesion was reported to have mucosal change overlying it. Newly available immunohistochemical stains were used to review the lesion to assess the potential for aggressiveness and proliferative changes. All the biomarkers were unremarkable, suggesting that the progression of the initial lesion could not have been predicted with the current immunohistochemical stains. This report discusses the diagnosis and treatment of this unusual scenario involving progression of a benign lesion to a malignant hybrid.
Assuntos
Carcinoma de Células Escamosas/diagnóstico , Carcinoma Verrucoso/diagnóstico , Neoplasias Mandibulares/diagnóstico , Complicações Neoplásicas na Gravidez/diagnóstico , Adulto , Transplante Ósseo , Carcinoma de Células Escamosas/cirurgia , Carcinoma Verrucoso/cirurgia , Feminino , Seguimentos , Humanos , Doenças Mandibulares/diagnóstico , Neoplasias Mandibulares/cirurgia , Terapia Neoadjuvante , Estadiamento de Neoplasias , Cistos Odontogênicos/diagnóstico , Gravidez , Complicações Neoplásicas na Gravidez/cirurgia , Procedimentos de Cirurgia Plástica , Transplante de PeleRESUMO
The adenomatoid odontogenic tumor is an unusual lesion that usually presents in the anterior maxilla. In contrast, the odontoma is the most common odontogenic tumor. The concurrent occurrence of these tumors in a single lesion is extremely rare. Such a lesion occurred in the mandibular canine region of a 13-year-old boy. While the hard tissue component of the lesion consisted of irregularly organized enamel and dentin matrix, the soft tissue component was composed of loosely arranged spindle cells and whorled masses of cells. Ductlike structures were observed around eosinophilic matrix. The histopathologic findings were consistent with concurrent occurrence of an odontoma and adenomatoid odontogenic tumor.