The signal intensity characteristics of normal bone marrow in diffusion weighted imaging at various menstrual status women.

PURPOSE: Diffuse hyperintensities of the bone marrow in whole-body diffusion-weighted (DW) imaging (DWI) have been encountered more frequently in females aged 21-50 compared to elder females or men. Therefore, we aimed to visually evaluate DWI among pre-, peri- and postmenopausal women and to verify whether it correlates also quantitatively with hormonal status. METHOD: The prospective study was approved by our institutional review board and informed consent was obtained in a total of 70 healthy premenopausal, perimenopausal, and postmenopausal women aged 40-58 years from February 2017 to October 2017. The bone marrow DW imaging signal characteristics were visually evaluated in comparison to the erector spinae muscle. Imaging data were acquired using a 1.5 T MRI yielding signal intensity values from a DWI-pulse sequence (b-value of 800 s/mm2; apparent diffusion coefficient (ADC) maps from b-values of 0-800 s/mm2), and a T2 mapping sequence covering the L2-L4 lumbar vertebrae. Serous estradiol (E2), follicle stimulating hormone (FSH), and luteinizing hormone (LH) were measured through venous blood assay. The relationship of the mean DW signal intensity (SIDWI) with T2 values, female hormone level, and mean ADC were analyzed using Spearman's rho test. RESULTS: The proportion of diffuse DWI hyperintensities of the bone marrow was significantly higher in premenopausal (91% (21/23)) women compared to peri- (75% (18/24)) and postmenopausal (8% (2/23)) women. A positive correlation was observed for the mean SIDWI (median [interquartile range], 47.33 [30.14]) and mean T2 (mean ± SD, 121.01 ± 13.54) (r = 0.438, p < 0.001) as well as for the mean SIDWI and E2 (median [interquartile range], 52.45 [92.78]) (r = 0.407, p < 0.001). A negative correlation was observed for the mean SIDWI and serous FSH (median [interquartile range], 15.55 [42.08]) as well as for the mean SIDWI and serous LH (median [interquartile range], 6.96 [31.06]) (r = -0.557, p < 0.001; r = -0.535, p < 0.001; respectively), but no significant correlation was found for mean SIDWI and mean ADC (mean ± SD, 599.36 ± 82.70) (r = 0.099, p = 0.415). A negative correlation was also encountered for the mean T2 values and serous FSH (r = -0.339, p = 0.004) as well as for the mean T2 values and serous LH (r = -0.281, p = 0.018). CONCLUSIONS: The mean SIDWI correlates positively with mean T2 and serous E2 values, while there's no significant correlation with mean ADC, indicating that T2 shine-through effects might interfere with bone marrow signaling on DW images. Knowledge of the bone marrow signal characteristics changing in DW images in close relationship with menstrual status is essential to correctly interpret DWI in clinical practice.

Post-Traumatic Stress and School Adaptation in Adolescent Survivors Five Years after the 2010 Yushu Earthquake in China.

(1) Background: The devastating Ms 7.1 earthquake struck Yushu city, China, in 2010, leading to serious consequences and damage in the central Tibetan Plateau. This study aimed to assess school adaptation and post-traumatic stress disorder (PTSD) symptoms of adolescent survivors five years after the Yushu earthquake. (2) Methods: A large-scale, school-based mental health survey was conducted 5 years after the earthquake among Tibetan students in the city of Yushu using the Adolescent's School Adaptation Scale (ASAS) and the PTSD Checklist. (3) Results: A total of 1976 questionnaires were collected. A total of 30.7% of Tibetan adolescents had poor school adaptation and 19.5% were estimated as having probable PTSD. Logistic regression showed that females (OR = 0.73, 95% CI: 0.60-0.89), senior students (OR = 0.48, 95% CI: 0.39-0.59), and those who participated in post-disaster reconstruction (OR = 0.68, 95% CI: 0.54-0.85) were less likely to have poor school adaptation, while a positive association was observed among those buried under a collapsed building (OR = 1.47, 95% CI: 1.04-2.09) and those who experienced bereavement (OR = 1.77, 95% CI: 1.27-2.45). Students who had experienced bereavement were also more likely to have PTSD (OR = 1.60, 95% CI: 1.12-2.28). (4) Conclusions: The post-traumatic effects of the Yushu earthquake on Tibetan adolescents were severe and long-lasting. Sustainable long-term mental health services to help adolescents to restructure their mental health are necessary.

Signal characteristics of normal adult bone marrow in whole-body diffusion-weighted imaging.

BACKGROUND: Knowledge of the signal characteristics of normal adult bone marrow in whole-body diffusion-weighted (DW) images (WB-DWI) is essential for correctly interpreting DW images in clinical practice; however, these factors have not yet been clearly determined. PURPOSE: To evaluate the signal characteristics of normal adult bone marrow in WB-DWI, to correlate these characteristics with age and gender, and to determine the causes of these phenomena. MATERIAL AND METHODS: Ninety-eight healthy volunteers underwent WB-DWI (b = 0 and 800 s/mm(2)). Two radiologists visually evaluated the signal characteristics of bone marrow in DW images separately. One radiologist measured the apparent diffusion coefficient (ADC) of the thoracic and lumbar vertebrae, bilateral femur (including head, neck, and proximal and distal femoral shaft), bilateral humeral head, ilium, and scapula. The signal characteristics of normal bone marrow were analyzed. RESULTS: The visual evaluation results of DW images indicated that hyperintensity of bone marrow was more frequently seen in women aged 21-50 years (68.4%) than in men aged 21-50 years (3.3%) (P < 0.001), men aged 51-81 years (5.9%) (P < 0.001), and women aged 51-81 years (15.4%) (P = 0.001). However, no statistically significant difference was found between men and women aged 51-81 years (P = 0.565). The ADC of bone marrow was significantly higher in women than in men aged 21-50 years. Bone marrow ADC showed significant negative correlation with age in women but not in men. CONCLUSION: The signal intensity of bone marrow varies with age and gender in DW images. ADC and the T2 shine-through effect contributed to the bone marrow signal intensity in DW images, and the latter effect may predominate.

Differentiating benign from malignant bone tumors using fluid-fluid level features on magnetic resonance imaging.

OBJECTIVE: To analyze different fluid-fluid level features between benign and malignant bone tumors on magnetic resonance imaging (MRI). MATERIALS AND METHODS: This study was approved by the hospital ethics committee. We retrospectively analyzed 47 patients diagnosed with benign (n = 29) or malignant (n = 18) bone tumors demonstrated by biopsy/surgical resection and who showed the intratumoral fluid-fluid level on pre-surgical MRI. The maximum length of the largest fluid-fluid level and the ratio of the maximum length of the largest fluid-fluid level to the maximum length of a bone tumor in the sagittal plane were investigated for use in distinguishing benign from malignant tumors using the Mann-Whitney U-test and a receiver operating characteristic (ROC) analysis. Fluid-fluid level was categorized by quantity (multiple vs. single fluid-fluid level) and by T1-weighted image signal pattern (high/low, low/high, and undifferentiated), and the findings were compared between the benign and malignant groups using the χ(2) test. RESULTS: The ratio of the maximum length of the largest fluid-fluid level to the maximum length of bone tumors in the sagittal plane that allowed statistically significant differentiation between benign and malignant bone tumors had an area under the ROC curve of 0.758 (95% confidence interval, 0.616-0.899). A cutoff value of 41.5% (higher value suggests a benign tumor) had sensitivity of 73% and specificity of 83%. CONCLUSION: The ratio of the maximum length of the largest fluid-fluid level to the maximum length of a bone tumor in the sagittal plane may be useful to differentiate benign from malignant bone tumors.