1.
Arch Pharm Res
; 35(9): 1525-31, 2012 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23054708
RESUMO
A series of novel artemisinin derivatives were synthesized from artemisinin and different anilines. All compounds were obtained as ß-isomers. The target compounds were evaluated for inhibition activity against Plasmodium falciparum falcipain-2 in vitro, and most of them exhibited potent inhibition in the low micromolar range and proved to be new types of falcipain-2 inhibitors.