Association between gut microbiota and autoimmune cholestatic liver disease, a Mendelian randomization study.

Background: Previous studies have suggested that the gut microbiota (GM) is closely associated with the development of autoimmune cholestatic liver disease (ACLD), but limitations, such as the presence of confounding factors, have resulted in a causal relationship between the gut microbiota and autoimmune cholestatic liver disease that remains uncertain. Thus, we used two-sample Mendelian randomization as a research method to explore the causal relationship between the two. Methods: Pooled statistics of gut microbiota from a meta-analysis of genome-wide association studies conducted by the MiBioGen consortium were used as an instrumental variable for exposure factors. The Pooled statistics for primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) were obtained from the R9 version of the FinnGen database (https://r9.finngen.fi/). Inverse-variance Weighted (IVW), cML-MA, MR-Egger regression, Weighted median (WME), Weighted mode (WM), and Simple mode (SM) were used to detect the association between intestinal flora and the causal relationship between intestinal flora and ACLD, in which IVW method was dominant, was assessed based on the effect indicator dominance ratio (odds ratio, OR) and 95% confidence interval (CI). Sensitivity analysis, heterogeneity test, gene pleiotropy test, MR pleiotropy residual sum and outlier test (MR-PRESSO) were combined to verify the stability and reliability of the results. Reverse Mendelian randomization analysis was performed on gut microbiota and found to be causally associated with ACLD. Results: The IVW results showed that the relative abundance of the genus Clostridium innocuum group, genus Butyricicoccus, and genus Erysipelatoclostridium was negatively correlated with the risk of PBC, that is, increased abundance reduced the risk of PBC and was a protective, and the relative abundance of the genus Eubacterium hallii was positively correlated with the risk of PSC, which is a risk factor for PSC. Family Clostridiaceae1 and family Lachnospiraceae were negatively correlated with the risk of PSC, which is a protective factor for PSC. Conclusion: This study found a causal relationship between gut microbiota and ACLD. This may provide valuable insights into gut microbiota-mediated pathogenesis of ACLD. It is necessary to conduct a large-sample randomized controlled trial (RCT) at a later stage to validate the associated role of the relevant gut microbiota in the risk of ACLD development and to explore the associated mechanisms.

Study on the spatio-temporal evolution and influencing factors of farmland abandonment on a county scale.

The protection of farmland resources is related to world food security, as well as the smooth realization of the goals of UN 2030 Agenda for Sustainable Development and China's Rural Revitalization Plan. As the most active region in the global economic development and one of the main grain producing areas, the problem of farmland abandonment in the Yangtze River Delta gradually appears with the rapid development of urbanization. Therefore, based on the interpretation data of remote sensing images and field survey data of three periods in 2000, 2010, and 2018, this study used Moran's I and geographical barycenter model to reveal the spatiotemporal evolution law of farmland abandonment in Pingyang County of the Yangtze River Delta. And then, this study selected 10 indicators covering four categories: geography, proximity, distance, and policy, and used random forest model to reveal the main influencing factors of farmland abandonment in the study area. The results showed that the abandoned farmland increased from 441.58 hm2 in 2000 to 5797.40 hm2 in 2018. The hot spot and barycenter of land abandonment gradually shifted from the western mountainous areas to the eastern plain areas. Altitude and slope were the main factors affecting the farmland abandonment. The high the altitude and the great the slope, the farmland abandonment in mountainous areas were serious. The proximity factors had a greater impact on the expansion of farmland abandonment from 2000 to 2010, and then the impact weakened. In view of the above analysis, the countermeasures and suggestions for maintaining food security were finally put forward.

Research on the influence of land use change to habitat of cranes in Shengjin Lake wetland.

Shengjin Lake wetland reserve is an important habitat for the winter cranes of our country, and the change of land use structure in the area have had a vital influence on the winter cranes and their habitat. The TM remote sensing images of 1986-2015 years were selected in this paper, and the land use change model and gray relational analysis model were used to analyze the effect of land use degree on the habitat of the winter crane and correlation degree between cranes and land use of Shengjin lake wetland. The land use transformation method was employed to analyze the transfer of the habitat of cranes and the relationship between the size of the cranes habitat and the number of populations. The results showed that the degree of land use change fluctuated greatly in different periods, and comprehensive index of land use degree between 220 and 260, also the land use was based on woodland, grassland, and water and their effect on the habitat was limited; the marsh land had the highest retention rate among the cranes habitat being 34.44%. While the reed flat had the lowest rate, only 15.36%, and the reed breach land was mainly transferred to marsh and dry land, 23.22% and 18.16%, respectively. The mud was mainly transferred to water and farmland, respectively, for 31.79% and 27.75%; except the period from 2011 to 2015, the change of habitat area was basically consistent with the change of the number of cranes.

Correction to: Study on habitat suitability of overwintering cranes based on landscape pattern change-a case study of typical lake wetlands in the middle and lower reaches of the Yangtze River.

The correct corresponding Author of this paper is Bin Dong.

Study on habitat suitability of overwintering cranes based on landscape pattern change-a case study of typical lake wetlands in the middle and lower reaches of the Yangtze River.

Shengjin Lake wetland is located in the middle and lower reaches of the Yangtze River in China. It is a typical lake-type wetland and is also an ideal place for rare cranes to overwintering. The changes of wetland landscape are closely related to the habitat quality of wintering cranes. It is of great significance to study the habitat change of wintering cranes in wetland for wetland ecological restoration and restoration. In this paper, we analyze four kinds of winter cranes and wetland landscape pattern types from the years 1986 to 2015. Also, we adopted the Pearson correlation analysis method to analyze the relationship between wetland landscape types and crane population, and the main landscape types of cranes habitat were obtained. We selected disturbance degree, food richness, vegetation cover, and hydrological condition as the main factors affecting wintering habitat of cranes. We established a habitat suitability index model for wintering cranes and generated habitat suitability assessment maps by ArcGIS. The results show that the change of landscape pattern in Shengjin Lake protected area was obvious, the number of wetland patches increased, the fragmentation degree of landscape increased, the landscape patch difference became smaller, and the diversity index and evenness index increased gradually. From 1986 to 2015, the number of wintering cranes decreased and the habitat suitability index of wintering cranes decreased from 0.845 to 0.465, and the habitat suitability of wintering cranes fell from 13,577.11 to 7424.42 ha, which showed the overall habitat deteriorated significantly and had a positive correlation between the crane population and habitat suitability.