Synthesis and Fluorescence Sensing for Nitro Explosives and Pesticides of Two Cd-Coordination Polymers.

Two cadmium coordination polymers (CPs), {[Cd(zgt)(2,2'-bipy)(H2O)]·H2O}n (1) and {[Cd(zgt)(BPP)(H2O)]·H2O}n (2) (H2zgt = 5-methoxyresorcinic acid, 2,2'-bipy = 2,2'-bipyridine, and BPP = 1,3-bis(4-pyridyl)propane), were prepared by the hydrothermal method. The structures of CPs 1-2 were characterized by IR, TGA, X-ray powder diffraction, and elemental analysis. The single-crystal structure analysis shows that CP 1 is a typical 1D chain structure and CP 2 belongs to a 2D layered structure. Based on the excellent luminescence properties of CP 1 and 2, fluorescence sensing experiments were carried out for explosives and pesticides. The results of the explosion sensing experiment showed that CP 1 and 2 had an excellent fluorescence quenching effect on PNBA (p-nitrobenzoic acid) and TNP (2,4,6-trinitrophenol), respectively, and the detection limits were 3.28 and 11.4 nM, respectively. Interestingly, both CP 1 and 2 showed good fluorescence quenching against the pesticide fluridine (Flu), and CP 1 had a lower detection limit and was more sensitive. In addition, the fluorescence quenching mechanism was discussed in detail by the UV absorption spectrum and density functional theory. In order to explore its practical application, the content of Flu in water samples was detected by a labeling recovery method.

Synthesis of a Cd-MOF Fluorescence Sensor and Its Detection of Fe3+, Fluazinam, TNP, and Sulfasalazine Enteric-Coated Tablets in Aqueous Solution.

A Cd-based metal-organic framework (Cd-MOF), named after {[Cd(ttc)(H2O)]·H2O}n (ttc = 1-imidazole-1-yl-2,4,6-benzene-tricarboxylic acid), was synthesized using the solvothermal reaction. The single-crystal structure was determined by single X-ray diffraction analysis, and crystalline characteristics and composition were confirmed by powder X-ray diffraction (PXRD) and thermogravimetric analysis (TG), respectively. Structural analysis showed that the Cd2+ ion is in the seven-coordinated mode, in which ttc2- ion adopts the µ4-η1-η1-η2-η2 coordination mode. It is worth noting that the Cd2+ ion is connected to ttc2- to form a 2D network, and the adjacent 2D network is expanded into a 3D supramolecular network structure through weak hydrogen bonds. The fluorescence sensing experiments indicated that Cd-MOF could not only be used as a fluorescence sensor for Fe3+, fluazinam (FLU), and 2,4,6-trinitrophenolol (TNP) but also for sulfasalazine detection in aqueous solution. To verify the sensitivity of the fluorescent probe, we calculated its detection limit: 5.34 × 10-8 M (Fe3+), 7.8 × 10-8 M (FLU), 1.21 × 10-7 M (TNP), and 2.67 × 10-7 M (SECT). In addition, the quenching mechanism was thoroughly studied.

Zn-MOFs composites loaded with silver nanoparticles are used for fluorescence sensing pesticides, Trp, EDA and photocatalytic degradation of organic dyes.

The abuse of pesticides, antibiotics, organic solvents, etc., not only deteriorates the ecological environment, but even affects the normal development of organisms, posing a serious threat to global public health.Efficient and sensitive detection of pesticides, antibiotics, organic solvents and so on are very important, but also a challenge to scientists. By depositing Ag nanoparticles on the surface of Zn-MOF (1: {[Zn2(bta)(bpy)(H2O)2]·2H2O}n), a new type of composite material (Ag@1) was successfully synthesized and analyzed by TEM, EDS, XPS, XRD, IR and other characterization methods. Ag@1 can serve as multi-response fluorescence sensor to detect pesticides (fluazinam (FLU) and emamectin benzoate (EMB)), Tryptophan (Trp) and Ethylenediamine (EDA). In particular, Ag@1 showed "turn-off" fluorescence sensing for FLU and EDA, and "turn-on" fluorescence sensing for EMB and Trp. It is worth mentioning that we further explored its analysis of FLU and Trp in real water samples and fetal bovine serum. The recoveries are satisfactory, 97.95 % - 102.39 % and 96.69 % - 101.85 %, respectively. In addition, the photocatalytic performance of Ag@1 was found to be excellent, the degradation rate of methylene blue (MB) reached 86 %, and its degradation mechanism was discussed.

Intervention effect of injury control orthopedic strategy on fat embolism syndrome associated with long shaft fracture of lower limb / 中国骨伤

OBJECTIVE@#To observe the intervention effect of damage control orthopaedic(DCO) strategy on fat embolism syndrome(FES) associated with long shaft fracture of lower limbs.@*METHODS@#Retrospective analysis was made on the clinical data of 163 patients with FES associated with lower limb long shaft fractures admitted from January 2015 to May 2021. They were divided into two groups based on the time point of implementing DCO strategy in January 2018. Total of 92 patients were admitted from January 2015 to December 2017 as the control group, and other 71 patients were admitted from January 2018 to May 2021 as the intervention group. The hospital mortality, arterial oxygen saturation (SaO2), arterial partial pressure of oxygen (PaO2) and oxygenation index (OI), hemoglobin (Hb), platelet count(PLT), Harris score of hip joint, HSS score of knee joint, AOFAS score of ankle joint, clinical efficacy and complications were observed and compared between two groups.@*RESULTS@#Total of 163 patients were followed up for 12 to 18 months with an average of (16.91±1.22) months. The in-hospital mortality rate in the intervention group was 2.82% (2/71), and that in the control group was 16.30% (15/92), the difference between two groups was statistically significant(χ2=6.455, P<0.05). After the intervention, SaO2, PaO2 and OI in two groups were higher than those before the intervention(P<0.05), and after the intervention, SaO2, PaO2 and OI in two groups were statistically significant(P<0.05). Hb and PLT in two groups after intervention were higher than those before intervention (P<0.001), and there was statistically significant difference in Hb and PLT between two groups after intervention (P<0.05). The Harris score of hip joint, HSS score of knee joint and AOFAS score of ankle joint in both groups after 3 months of treatment were better than those before treatment (P<0.05). The total clinical effective rate of the intervention group was higher than that of the control group(χ2=4.194, P<0.05). The total incidence of complications in the intervention group was lower than that in the control group(χ2=4.747, P<0.05).@*CONCLUSION@#DCO strategy is helpful to reduce the in-hospital mortality of patients with FES associated with long shaft fracture of lower extremities, eliminate FES symptoms and stabilize vital signs, gain time advantage for phase Ⅱ definitive surgery, and has significant clinical intervention effect, which is worth popularizing.

A mixed-valence [CoII4CoIII2] cluster with defect disk-shaped topology.

The employment of the new Schiff base ligand 2-[(4-chloro-2-hydroxybenzylideneamino)methyl]phenol (H2L) bearing O2N donors for the preparation of a novel Co6 cluster is reported. The hexanuclear cobalt complex, namely, di-µ2-acetatotetrakis{µ2-2-[(4-chloro-2-oxidobenzylideneamino)methyl]phenolato}tetra-µ3-methanolato-tetracobalt(II)dicobalt(III), [CoII4CoIII2(C14H10ClNO2)4(CH3COO)2(CH3O)4], was obtained using Co(CH3COO)2·4H2O and H2L as starting materials in MeOH under solvothermal conditions. The six metal ions are linked together by the µ3-O atoms of four deprotonated MeOH molecules, two CH3COO- units and six phenolate O atoms of four L2- ligands to form a defect disk-shaped topology. DC magnetic susceptibility investigations revealed the existence of antiferromagnetic interactions in the Co6 cluster.

Three new bioactive flavonoid glycosides from Viscum album / 中国天然药物

Two new flavonoid glycosides, named viscumneoside XII (1), and viscumneoside XIII (2); a new dihydrogen flavonoid glycoside product named viscumneoside XIV (3), were isolated from the aerial part of Viscum album, along with seven known compounds (4-10). Their structures were identified by analysis of spectroscopic data. In addition, cytotoxicity assay showed that 1, 2 and 3 possessed significant inhibitory activities against C6, A549 and MDA-MB-231 (the inhibition rate arrived about 50%, 70% and 74% respectively with IC ≤ 60.00 μmol·L), while the inhibition of TF-1 and Hela was not significant.

µ-4,4'-Bipyridine-bis-[aqua-(4-hy-droxy-pyridine-2,6-dicarboxyl-ato)copper(II)].

The title compound, [Cu(2)(C(7)H(3)NO(5))(2)(C(10)H(8)N(2))(H(2)O)(2)], exhibits a centrosymmetric binuclear molecule. Each completely deprotonated 4-hy-droxy-pyridine-2,6-dicarb-oxy-lic acid mol-ecule assumes a tridentate chelating coordination mode. The square-pyramidal coordination geometry around the Cu(II) ion is completed by the bridging bipyridine ligand and an apical water molecule. Adjacent complexes are connected via O-H⋯O and C-H⋯O hydrogen bonds to generate a three-dimensional supra-molecular structure.

[Optimization of culture conditions for production of extracellular polysaccharides by Morchella esculenta].

OBJECTIVE: To optimize the conditions for exopolysaccharides (EPS) production by Morchella esculenta GIM 5.69. METHODS: A Plackett-Burman design was used to evaluate the effects of variables factors. The optimal combined conditions for maximum polysaccharide production were further optimized by response surface methodology. RESULTS: The optimal fermentation conditions were determined as follows: glucose 30%, cultivation time 5.98 d, rotary speed 217.44 r/min. The average yield of polysaccharide validation experiments was 53.04%, the relative error was 1.64%. CONCLUSION: This research has the vital significance regarding the Morchella esculenta polysaccharide function of the product development and the application.

Isolation, partial characterisation and immunomodulatory activities of polysaccharide from Morchella esculenta.

BACKGROUND: Polysaccharides extracted from fungi or algae have shown a variety of medical activities, and the exploitation of polysaccharides for application in pharmacy has been very promising. In this study, the immunomodulatory properties of polysaccharides from Morchella esculenta were investigated to identify immunostimulatory activity and potentially contribute to the therapeutic potential of Morchella esculenta. RESULTS: A water-soluble polysaccharide, MEP, was obtained from the fermentation broth of Morchella esculenta. Two fractions of this polysaccharide (MEP-I and MEP-II) were extracted and purified. High-performance gel permeation chromatography analysis showed the average molecular weights of two polysaccharides. Structural properties and compositions of these two fractions were examined by Fourier transform infrared and a high-performance liquid chromatography with an evaporative light scattering detector. Active experiments suggested that the MEP had typical immunostimulatory activity. CONCLUSION: These bioactivity tests showed that the polysaccharides from Morchella esculenta presented significant immune modulating activity, and this finding may offer the basis for the popular use of polysaccharides in functional foods or medicine.

Contrast Research on Decreasing Rate of Serum ?_2-Microglobulin before and after Children′s Hemodialysis and Hemodiafiltation / 实用儿科临床杂志

Objective To explore the influence of hemodialysis(HD) and henodiafiltation on serum ?_2-microglobulin(?_2-MG) of children with acute renal failure and contrast research on declining rate of serum ?_2-MG before and after(children′s) HD and HDF.(Met-)hods By Branc Dialog HD machine of double-pump,HDF for 18 times and HD for 20 times were given to children with acute renal(fai-)lure.The serum ?_2-MG were observed before and after HD and HDF.Results A great difference was observed in level of serum ?_2-MG between before and after HD and HDF.In HDF group,there was significant difference in level of serum ?_2-MG before and after HDF(P

Application of Hemodialysis and Filtration in Children with Acute Renal Failure / 实用儿科临床杂志

Objective To discuss the application of the hemodialysis and filtration(HDF) in children with acute renal failure(ARF).Methods By Branc Dialog hemodialysis machine of double-pump,HDF for 19 times and hemodialysis(HD) for 21 times were given to the children with ARF.The serum blood urea nitrogen(BUN),creatinine(Cr),uric acid(UA),?_2 microglobulin(?_2-MG) and the rate of the heart,blood pressure,temperature were observed before and after HD and HDF.Results The clearance rates of BUN,Cr,UA,(?_2-)MG of HDF were markedly higher than those of HD(P