Animal experimental study of intra-articular injection of S-methylisothiourea for treatment of temporomandibular joint osteoarthrosis / 华西口腔医学杂志

<p><b>OBJECTIVE</b>To investigate the efficacy of S-methylisothiourea (SMT) for treatment of temporomandibular joint osteoarthrosis (TMJOA) of goats.</p><p><b>METHODS</b>Nine purebred black goats were randomly devided into three groups: Normal control group, control group and experimental group. The upper compartments of both temporomandibular joint of the goats in control group and experimental group were injected with collagenase only once to induce osteoarthrosis. Normal control group received no treatment. The upper compartments of both TMJ were injected with 0.5 mL of normal saline, and experimental group, the upper compartments of both TMJ were injected with 0.5 mL of SMT. The TMJ of goats was examined with scanning electron microscopy and microscopy after sacrificed.</p><p><b>RESULTS</b>Examined in light microscopy and scanning electron microscopy, normal control group showed normal performance, the control group showed severe osteoarthrotic changes in the temporal surface, disk and condyle, while the experimental group showed improvement of different degree.</p><p><b>CONCLUSION</b>On the basis of 3-month following-up study, repeated intra-articular injection of SMT may play a role in inhibiting TMJOA progression.</p>

Effect of recombinant human bone morphogenetic protein-7 expressed in prokaryocyte to augment bone formation of alveolar ridge / 华西口腔医学杂志

<p><b>OBJECTIVE</b>To investigate new bone formation of alveolar augmentation with recombinant human bone morphogenetic protein-7 (rhBMP-7) expressed in prokaryocyte.</p><p><b>METHODS</b>To create the model of rabbit extraction socket into which the composites of rhBMP-7 and the gelatin sponge was immediately implanted, then the samples were investigated 2, 4, 8 and 12 weeks postoperatively by gross observation, scanning electron microscope (SEM), quantitative measurement of calcium content and alkaline phosphatase (ALP) activity.</p><p><b>RESULTS</b>There was significant difference in height of alveolar ridge absorpted between the experimental groups and the carrier control groups through gross observation. The result of SEM showed that bone healing in rhBMP-7 groups was 4-6 weeks earlier than that of control groups. ALP activity in rhBMP-7 groups were obviously high compared with that of control groups.</p><p><b>CONCLUSION</b>The BMP-7 has a satisfactory osteoinduction ability to promote new bone formation and prevent alveolar bone absorption.</p>