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1.
Clin Microbiol Infect ; 21(7): 701-9, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25882354

RESUMO

Human adenovirus (HAdV) infections constitute a major cause of morbidity in paediatric haematopoietic stem cell transplant (HSCT) patients. New antiviral treatments offer promising perspectives. However, it remains challenging to identify patients at risk for disseminated infection, and who should receive early antiviral intervention. We conducted a longitudinal study of allogeneic HSCT recipients, including weekly HAdV monitoring, to determine the risks factors associated with HAdV infection and dissemination, and to assess whether HAdV loads in stools may be used as surrogate markers for HAdV dissemination. Between September 2010 and December 2011, out of 72 patients, the cumulative incidence rates at day 100 of HAdV digestive infection, systemic infection and related disease were 35.9%, 24.0%, and 18.3%, respectively. In multivariate analysis, the risk factors for HAdV digestive and systemic infection were cord blood and in vitro T-cell depletion. Graft-versus-host disease (GVHD) grade >2 was also associated with systemic infection. In patients with HAdV digestive shedding, GVHD grade >2 and HAdV load in stools were the only risk factors for systemic infection. The median peak levels of HAdV in stool were 7.9 and 4.0 log10 copies/mL, respectively, in patients with HAdV systemic infection and in those without. HAdV monitoring in stools of paediatric HSCT recipients receiving cord blood or in vitro T-cell depleted transplants helps to predict patients at risk for HAdV systemic infection. Our results provide a rationale for randomized controlled trials to evaluate the benefit of anti-HAdV pre-emptive treatments based on HAdV DNA levels in stools.


Assuntos
Infecções por Adenoviridae/epidemiologia , Infecções por Adenoviridae/prevenção & controle , Antivirais/uso terapêutico , Transplante de Células-Tronco Hematopoéticas , Transplantados , Viremia/epidemiologia , Viremia/prevenção & controle , Infecções por Adenoviridae/diagnóstico , Quimioprevenção/métodos , Criança , Pré-Escolar , Fezes/virologia , Feminino , Humanos , Incidência , Estudos Longitudinais , Masculino , Fatores de Risco , Carga Viral , Viremia/diagnóstico
2.
Arch Pediatr ; 21(11): 1246-9, 2014 Nov.
Artigo em Francês | MEDLINE | ID: mdl-25267195

RESUMO

Rhabdoid tumors are a heterogeneous family of aggressive tumors affecting young children. Their grouping within a single entity is recent, following the discovery of a bi-allelic inactivation of the hSNF5/INI1 tumor suppressor gene in tumoral cells. This bi-allelic inactivation of the hSNF5/INI1 gene found at the constitutional level in up to one-third of cases has led to the identification of a predisposal syndrome to rhabdoid tumors. Herein we report extrarenal rhabdoid tumors observed in three infants between 3 and 6 months of age, underlining the misleading feature of the clinical presentation and the aggressiveness of the disease. Finally, we also report the genetic patient care management strategy.


Assuntos
Neoplasias Abdominais/diagnóstico , Emergências , Neoplasias Hepáticas/diagnóstico , Tumor Rabdoide/diagnóstico , Neoplasias Abdominais/genética , Neoplasias Abdominais/terapia , Alelos , Amniocentese , Neoplasias Encefálicas/diagnóstico , Neoplasias Encefálicas/genética , Neoplasias Encefálicas/terapia , Proteínas Cromossômicas não Histona , Terapia Combinada , Análise Mutacional de DNA , Proteínas de Ligação a DNA , Evolução Fatal , Feminino , Genes Supressores de Tumor , Aconselhamento Genético , Humanos , Lactente , Neoplasias Hepáticas/genética , Neoplasias Hepáticas/terapia , Imageamento por Ressonância Magnética , Masculino , Gravidez , Tumor Rabdoide/genética , Tumor Rabdoide/terapia , Proteína SMARCB1 , Fatores de Transcrição , Ativação Transcricional/genética
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