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1.
Nat Commun ; 9(1): 2754, 2018 07 16.
Artigo em Inglês | MEDLINE | ID: mdl-30013188

RESUMO

Neural populations perform computations through their collective activity. Different computations likely require different population-level dynamics. We leverage this assumption to examine neural responses recorded from the supplementary motor area (SMA) and motor cortex. During visually guided reaching, the respective roles of these areas remain unclear; neurons in both areas exhibit preparation-related activity and complex patterns of movement-related activity. To explore population dynamics, we employ a novel "hypothesis-guided" dimensionality reduction approach. This approach reveals commonalities but also stark differences: linear population dynamics, dominated by rotations, are prominent in motor cortex but largely absent in SMA. In motor cortex, the observed dynamics produce patterns resembling muscle activity. Conversely, the non-rotational patterns in SMA co-vary with cues regarding when movement should be initiated. Thus, while SMA and motor cortex display superficially similar single-neuron responses during visually guided reaching, their different population dynamics indicate they are likely performing quite different computations.


Assuntos
Mãos/fisiologia , Córtex Motor/fisiologia , Neurônios Motores/fisiologia , Movimento/fisiologia , Vias Neurais/fisiologia , Animais , Mapeamento Encefálico , Eletrodos Implantados , Eletroencefalografia , Eletromiografia , Mãos/inervação , Macaca mulatta , Masculino , Córtex Motor/citologia , Neurônios Motores/citologia , Redução Dimensional com Múltiplos Fatores , Músculo Esquelético/fisiologia , Vias Neurais/citologia , Estimulação Luminosa , Desempenho Psicomotor/fisiologia , Amplitude de Movimento Articular/fisiologia , Tempo de Reação/fisiologia , Técnicas Estereotáxicas
2.
Curr Opin Neurobiol ; 50: 232-241, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29738986

RESUMO

Modern large-scale multineuronal recording methodologies, including multielectrode arrays, calcium imaging, and optogenetic techniques, produce single-neuron resolution data of a magnitude and precision that were the realm of science fiction twenty years ago. The major bottlenecks in systems and circuit neuroscience no longer lie in simply collecting data from large neural populations, but also in understanding this data: developing novel scientific questions, with corresponding analysis techniques and experimental designs to fully harness these new capabilities and meaningfully interrogate these questions. Advances in methods for signal processing, network analysis, dimensionality reduction, and optimal control-developed in lockstep with advances in experimental neurotechnology-promise major breakthroughs in multiple fundamental neuroscience problems. These trends are clear in a broad array of subfields of modern neuroscience; this review focuses on recent advances in methods for analyzing neural time-series data with single-neuronal precision.


Assuntos
Encéfalo/citologia , Ciência de Dados , Neurônios/fisiologia , Neurociências , Potenciais de Ação/fisiologia , Animais , Encéfalo/diagnóstico por imagem , Cálcio/metabolismo , Humanos , Aprendizado de Máquina , Modelos Neurológicos
3.
Bull Entomol Res ; 102(4): 468-76, 2012 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-22314028

RESUMO

Cotton growing landscapes in Australia have been dominated by dual-toxin transgenic Bt varieties since 2004. The cotton crop has thus effectively become a sink for the main target pest, Helicoverpa armigera. Theory predicts that there should be strong selection on female moths to avoid laying on such plants. We assessed oviposition, collected from two cotton-growing regions, by female moths when given a choice of tobacco, cotton and cabbage. Earlier work in the 1980s and 1990s on populations from the same geographic locations indicated these hosts were on average ranked as high, mid and low preference plants, respectively, and that host rankings had a heritable component. In the present study, we found no change in the relative ranking of hosts by females, with most eggs being laid on tobacco, then cotton and least on cabbage. As in earlier work, some females laid most eggs on cotton and aspects of oviposition behaviour had a heritable component. Certainly, cotton is not avoided as a host, and the implications of these finding for managing resistance to Bt cotton are discussed.


Assuntos
Comportamento Animal/efeitos dos fármacos , Gossypium/genética , Mariposas/efeitos dos fármacos , Oviposição/efeitos dos fármacos , Plantas Geneticamente Modificadas , Animais , Austrália , Brassica , Produtos Agrícolas/parasitologia , Feminino , Mariposas/genética , Nicotiana
4.
J Evol Biol ; 25(2): 244-51, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22225990

RESUMO

Evolutionary theory predicts that herbivorous insects should lay eggs on plants in a way that reflects the suitability of each plant species for larval development. Empirical studies, however, often fail to find any relationship between an adult insect's choice of host-plant and offspring fitness, and in such cases, it is generally assumed that other 'missing' factors (e.g. predation, host-plant abundance, learning and adult feeding sites) must be contributing to overall host suitability. Here, I consider an alternative theory - that a fitness cost inherent in the olfactory mechanism could constrain the evolution of insect host selection. I begin by reviewing current knowledge of odour processing in the insect antennal lobe with the aid of a simple schematic: the aim being to explain the workings of this mechanism to scientists who do not have prior knowledge in this field. I then use the schematic to explore how an insect's perception of host and non-host odours is governed by a set of processing rules, or algorithm. Under the assumptions of this mechanistic view, the perception of every plant odour is interrelated, and seemingly bad host choices can still arise as part of an overall adaptive behavioural strategy. I discuss how an understanding of mechanism can improve the interpretation of theoretical and empirical studies in insect behaviour and evolution.


Assuntos
Evolução Biológica , Insetos/fisiologia , Animais , Antenas de Artrópodes/fisiologia , Comportamento Animal , Odorantes , Percepção Olfatória , Oviposição , Plantas
5.
J Chem Ecol ; 30(10): 2071-84, 2004 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-15609838

RESUMO

The ability of adult cotton bollworm, Helicoverpa armigera (Hübner), to distinguish and respond to enantiomers of alpha-pinene was investigated with electrophysiological and behavioral methods. Electroantennogram recordings using mixtures of the enantiomers at saturating dose levels, and single unit electrophysiology, indicated that the two forms were detected by the same receptor neurons. The relative size of the electroantennogram response was higher for the (-) compared to the (+) form, indicating greater affinity for the (-) form at the level of the dendrites. Behavioral assays investigated the ability of moths to discriminate between, and respond to the (+) and (-) forms of alpha-pinene. Moths with no odor conditioning showed an innate preference for (+)-alpha-pinene. This preference displayed by naive moths was not significantly different from the preferences of moths conditioned on (+)-alpha-pinene. However, we found a significant difference in preference between moths conditioned on the (-) enantiomer compared to naive moths and moths conditioned on (+)-alpha-pinene, showing that learning plays an important role in the behavioral response. Moths are less able to distinguish between enantiomers of alpha-pinene than different odors (e.g., phenylacetaldehyde versus (-)-alpha-pinene) in learning experiments. The relevance of receptor discrimination of enantiomers and learning ability of the moths in host plant choice is discussed.


Assuntos
Comportamento Animal/efeitos dos fármacos , Aprendizagem/efeitos dos fármacos , Lepidópteros/efeitos dos fármacos , Monoterpenos/farmacologia , Odorantes , Animais , Comportamento Animal/fisiologia , Monoterpenos Bicíclicos , Relação Dose-Resposta a Droga , Eletrofisiologia , Aprendizagem/fisiologia , Lepidópteros/fisiologia , Monoterpenos/química , Neurônios/efeitos dos fármacos , Neurônios/fisiologia , Estereoisomerismo
6.
Arch Intern Med ; 161(5): 760-6, 2001 Mar 12.
Artigo em Inglês | MEDLINE | ID: mdl-11231711

RESUMO

BACKGROUND: The cost associated with education of residents is of interest from an educational as well as a political perspective. Most studies report a single institution's actual incurred costs, based on traditional cost accounting methods. We quantified the minimum instructional and program-specific administrative costs for residency training in internal medicine. METHODS: Using the Accreditation Council for Graduate Medical Education program requirements for internal medicine as minimum standards for teaching and administrative effort, we quantified the minimum instructional and administrative costs for sponsorship of an accredited residency program in internal medicine. We also analyzed the impact of resident complement and program curricular emphasis (outpatient, inpatient, or traditional) on the per-resident cost. The main outcome measure was the minimum annual per-resident cost of instruction and program-specific administration. RESULTS: Using the assumptions in this model, we estimated the annual cost per resident of implementing the program requirements to be $50,648, $35,477, $28,517, and $26,197 for inpatient intensive residency programs with resident complements of 21, 42, 84, and 126, respectively. For outpatient intensive residency programs of identical resident complements, we estimated the annual per-resident cost to be $58,025, $42,853, $35,894, and $33,574 for similar resident complements. Fixed costs mandated by the program requirements, which did not vary across program size or configuration, were estimated to be $640,737. CONCLUSIONS: There are fixed and variable costs associated with sponsorship of accredited internal medicine residency programs. The minimum cost per resident of education and departmental administration varies inversely with program size within the sizes examined.


Assuntos
Educação Continuada/economia , Medicina Interna/educação , Internato e Residência/economia , Pessoal Administrativo/economia , Pessoal Administrativo/organização & administração , Custos e Análise de Custo , Educação Continuada/organização & administração , Planejamento em Saúde , Humanos , Medicina Interna/organização & administração , Internato e Residência/organização & administração , Modelos Econômicos , Estados Unidos
7.
Inquiry ; 28(2): 194-9, 1991.
Artigo em Inglês | MEDLINE | ID: mdl-1829718

RESUMO

In this paper, we investigate the impact of closures on local access to hospital care. We measured the incremental travel time to alternate hospitals. The results show that even in rural markets, closures nearly always occur near open hospitals, which by itself may imply a minimal effect in terms of human welfare. These results support the view that hospital closures rarely directly limit general access to hospital care.


Assuntos
Fechamento de Instituições de Saúde , Acessibilidade aos Serviços de Saúde , Necessidades e Demandas de Serviços de Saúde , Fatores de Tempo , Viagem , Estados Unidos
10.
Popul Stud (Camb) ; 26(2): 223-31, 1972 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-22074163

RESUMO

Abstract Recently economists have demonstrated a renewed interest in the population problems of a mature society. This revival of interest has been sparked by the general recognition of the relationship between population growth and environmental problems and has led to general acceptance of the proposition that ' ... a zero rate of population growth is the only equilibrium rate that can be sustained'.(1) Consequently the literature produced during the discipline's last period of similar concern, a period running from the late 1920's through the 1940's, needs re-examination. At that time economists were primarily occupied with the implications of a declining rate of population growth and most anticipated the arrival of a stationary population within the foreseeable future. For most of the economists of this earlier period the onset of a stationary or declining population was fraught with dangers for mature capitalism.

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