RESUMO
Data from the US Health and Nutrition Examination Survey (HANES I) of 1971-1975 confirm the high prevalence of musculoskeletal impairments among United States adults. Musculoskeletal impairments tend to be more prevalent among older persons, and persons with less education and with lower annual family incomes. Prevalence rates are slightly higher in females than in males, while Whites and non-Whites are affected with almost equal frequency. Among persons reporting a history of musculoskeletal symptoms, those who have some disability tend to be older, non-White, of lower education and income, and widowed, separated, or divorced. Persons with multiple parts of the body involved, or reporting that their symptoms are due to accident or injury are also especially likely to report disability. Taken as a whole, the data suggest that medical, social, and economic factors all play a role in determining whether a person with musculoskeletal impairment goes on to develop disability related to his or her impairment.
Assuntos
Doenças Ósseas/epidemiologia , Pessoas com Deficiência , Inquéritos Epidemiológicos , Doenças Musculares/epidemiologia , Adulto , Fatores Etários , Idoso , Escolaridade , Feminino , Humanos , Renda , Masculino , Pessoa de Meia-Idade , Fatores Sexuais , Pessoa SolteiraAssuntos
Assistência ao Convalescente/organização & administração , Departamentos Hospitalares/organização & administração , Alta do Paciente , Serviço Social/organização & administração , Comportamento do Consumidor , Continuidade da Assistência ao Paciente , Hospitais com 100 a 299 Leitos , Humanos , Indiana , RiscoAssuntos
Desoxiaçúcares/farmacologia , Desoxiglucose/farmacologia , Leucemia Experimental/ultraestrutura , Animais , Agregação Celular/efeitos dos fármacos , Ciclo Celular , Membrana Celular/efeitos dos fármacos , Membrana Celular/metabolismo , Membrana Celular/ultraestrutura , DNA de Neoplasias/metabolismo , Desoxiglucose/metabolismo , Galactosiltransferases/metabolismo , Técnicas In Vitro , Lectinas/metabolismo , Lectinas/farmacologia , Leucemia Experimental/metabolismo , Camundongos , Sialiltransferases/metabolismoAssuntos
Regeneração Hepática , Biossíntese de Proteínas , RNA de Transferência/metabolismo , Tioguanina/farmacologia , Animais , Masculino , Metionina , Peptídeos , Poli A , Biossíntese de Proteínas/efeitos dos fármacos , Ratos , Proteínas Ribossômicas/metabolismo , Sementes/metabolismo , Triticum/metabolismoRESUMO
A series of tetramisole derivatives was synthesized and tested for inhibitory activity against alkaline phosphatase which was partially purified from a murine ascitic neoplasm resistant to 6-thiopurines (Sarcoma 180/TG). These agents included derivatives substituted with halogens, CH3, or NO2 groups at either the meta or para position of the phenyl ring of tetramisole and 2,3-dehydrotetramisole. The phenyl ring of tetramisole and 2,3-dehydrotetramisole was also replaced by a naphthyl ring, and the phenyl ring of 2,3-dehydrotetramisole was substituted by a thienyl ring system. The presence of both the thiazolidine and dihydroimidazole rings of tetramisole was found to be essential for enzyme inhibitory activity. Substitution of a naphthyl for the phenyl group and dehydrogenation at the 2,3 position of the thiazolidine ring were found to significantly enhance inhibitory activity for alkaline phosphatase. Tests employing (S)-(-)-6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole oxalate in combination with 6-thioguanine demonstrated that the inhibitor of alkaline phosphatase was capable of increasing the toxicity of 6-thioguanine to Sarcoma 180/TG cells in tissue culture.
