[T.O.M. ointment, breast feeding and serum estradiol in newborn infants. A double-blind, randomized controlled study]. / Pommade T.O.M., allaitement et estradiolémie des nouveau-nés, Etude contrôlée, randomisée, à double insu.

OBJECTIVE: To study whether there is an iatrogenic transfer of oestradiol through the use of T.O.M. ointment administered to prevent or to cure trophic changes in the breast while breastfeeding and what the dangers of plasma levels of oestradiol in the newborn will be. TYPE OF STUDY: Controlled, randomised, double blind. SUBJECTS AND METHODS: 80 mother/infant couples were included in the study: 40 received the ointment containing oestradiol (the treated group), and 40 received an ointment without oestradiol (the non-treated group); the ointment was applied before each breastfeeding from the 2nd to the 6th or 7th day of life. Mothers' milk and blood from the newborn babies were taken for estimating the levels of oestradiol using a radio-immunological technique. The total quantity of ointment was measured for each subject. RESULTS: The mean level of oestradiol in the treated mothers' milk was significantly higher (p. 0.0014) than in the milk of the mothers who had not been treated. The concentration of oestradiol in the plasma of the newborn dropped from the first to the last day of the trial without any difference in the treated or non-treated groups no matter what the sex of the child was, nor the quantity of ointment used.

In vivo changes of ionic composition of tumors treated by hyperthermia.

Experimental tumors submitted in vivo to hyperthermia, in the presence, or not, of lanthanum (La3+), have shown modifications in the concentration of extra- and intracellular cations. Sacrificed immediately after hyperthermia, only the group treated with La3+ presented ionic changes (lower magnesium and potassium). After 48 hours, in both cases calcium and sodium were increased while magnesium and potassium were decreased.