RESUMO
Seventeen young patients with relapsing schizophrenia and 13 normal controls matched for age, gender, and educational level underwent magnetic resonance imaging (MRI) scans. Three sagittal, eight axial, and seven coronal images were obtained for all subjects. Schizophrenic patients showed a reduction of brain tissue in the temporal lobes. Among the several brain structures identified, left temporal lobe area, but not ventricular brain ratio (VBR), discriminated between the two groups. As VBR has been reported to be increased in the more severe forms of schizophrenia, temporal lobe abnormalities may characterize the less severe cases of schizophrenia.
Assuntos
Imageamento por Ressonância Magnética , Esquizofrenia/patologia , Psicologia do Esquizofrênico , Lobo Temporal/patologia , Adulto , Encéfalo/patologia , Ventrículos Cerebrais/patologia , Doença Crônica , Corpo Caloso/patologia , Dominância Cerebral/fisiologia , Feminino , Humanos , Interpretação de Imagem Assistida por Computador , Imageamento por Ressonância Magnética/instrumentação , Masculino , Escalas de Graduação Psiquiátrica , Software , Tomografia Computadorizada por Raios XRESUMO
Twenty-seven chronic schizophrenics and nineteen controls, all male, were evaluated by computed tomography (CT) scans. Lateral, third and fourth ventricles and cerebral density numbers were measured. In the schizophrenic patients there was a significant increase in third ventricle width, Ventricular Brain Ratio (VBR) and there were significantly higher densities of white matter in the right frontal and parietal region.
Assuntos
Encéfalo/patologia , Ventrículos Cerebrais/patologia , Transtornos Neurocognitivos/patologia , Esquizofrenia/patologia , Tomografia Computadorizada por Raios X , Adulto , Córtex Cerebral/patologia , Doença Crônica , Dilatação Patológica/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Esquizofrenia Paranoide/patologiaRESUMO
The CT scans of 18 chronic schizophrenic patients and 17 controls were evaluated for Ventricular Brain Ratio (VBR) size. A trend for the patient group to have larger VBR than controls was present but did not reach statistical significance at the 5% level. Age was found to be an important correlate of VBR within the patient group but not among controls. In a stepwise multiple-regression model age, among other independent variables, can account for 47% of VBR variance in schizophrenic patients. Linear regression analysis did not reveal significant association between VBR and age in control subjects.
