RESUMO
HLA-B*15:679 and HLA-C*15:02:01:61 differ from HLA-B*15:12:01 and HLA-C*15:02:01:01 by a single nucleotides.
Assuntos
Alelos , Sequência de Bases , Antígenos HLA-C , Teste de Histocompatibilidade , Humanos , Antígenos HLA-C/genética , Índia , Éxons , Análise de Sequência de DNA/métodos , Polimorfismo de Nucleotídeo Único , Antígeno HLA-B15/genética , Antígeno HLA-B15/imunologia , Alinhamento de Sequência , CódonRESUMO
Allele variants HLA-C*01:02:01:74Q and -C*15:02:01:63 differ from -C*01:02:01:01 and -15:02:01:01 by a single nucleotide, respectively.
Assuntos
Alelos , Antígenos HLA-C , Teste de Histocompatibilidade , Humanos , Antígenos HLA-C/genética , Polimorfismo de Nucleotídeo Único , Éxons , Índia , Sequência de Bases , Análise de Sequência de DNA/métodosRESUMO
Novel HLA-C*06:02:01:94 and -C*15:02:01:58 alleles were detected during the routine HLA typing process.
RESUMO
The novel HLA-B*15:665 and HLA-C*12:02:02:23 alleles were detected during the routine HLA typing process.
RESUMO
Acute Myeloid Leukemia (AML) is a complex disease with rapid progression and poor/unsatisfactory outcomes. In the past few years, the focus has been on developing newer therapies for AML; however, relapse remains a significant problem. Natural Killer cells have strong anti-tumor potential against AML. This NK-mediated cytotoxicity is often restricted by cellular defects caused by disease-associated mechanisms, which can lead to disease progression. A stark feature of AML is the low/no expression of the cognate HLA ligands for the activating KIR receptors, due to which these tumor cells evade NK-mediated lysis. Recently, different Natural Killer cell therapies have been implicated in treating AML, such as the adoptive NK cell transfer, Chimeric antigen receptor-modified NK (CAR-NK) cell therapy, antibodies, cytokine, and drug treatment. However, the data available is scarce, and the outcomes vary between different transplant settings and different types of leukemia. Moreover, remission achieved by some of these therapies is only for a short time. In this mini-review, we will discuss the role of NK cell defects in AML progression, particularly the expression of different cell surface markers, the available NK cell therapies, and the results from various preclinical and clinical trials.
Assuntos
Leucemia Mieloide Aguda , Humanos , Leucemia Mieloide Aguda/patologia , Células Matadoras Naturais , Imunoterapia Adotiva/métodos , Receptores KIR/metabolismo , Citocinas/metabolismoRESUMO
The novel HLA-A*01:01:01:111 allele was detected during routine HLA typing.
Assuntos
Antígenos HLA-A , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Alelos , Índia , Teste de Histocompatibilidade , Antígenos HLA-A/genéticaRESUMO
The novel HLA-B*40:01:02:59 and HLA-C*05:01:73 alleles were detected during the routine HLA typing process.
Assuntos
Genes MHC Classe I , Antígenos HLA-B , Humanos , Alelos , Análise de Sequência de DNA , Antígenos HLA-B/genética , Índia , Sequenciamento de Nucleotídeos em Larga EscalaRESUMO
The novel HLA-C*12:02:47 allele was detected during routine HLA typing.
Assuntos
Antígenos HLA-C , Humanos , Antígenos HLA-C/genética , Alelos , ÍndiaRESUMO
The novel allele HLA-B*37:01:01:19 differs from B*37:01:01:01 by one nucleotide A->G in Intron 3 at gDNA1430.
Assuntos
Antígenos HLA-B , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Alelos , Íntrons , Índia , Antígenos HLA-B/genéticaRESUMO
The novel allele HLA-C*03:599 as compared with HLA-C*03:04:01:02 displays polymorphism at position; gDNA 1618 (G>T).
Assuntos
Antígenos HLA-C , Humanos , Antígenos HLA-C/genética , AlelosRESUMO
Novel HLA-A*33:03:62, -B*52:01:01:25 alleles and confirmatory HLA-A*02:01:209 allele were detected during the HLA typing process.
Assuntos
Genes MHC Classe I , Antígenos HLA-B , Humanos , Alelos , Antígenos HLA-B/genética , Teste de Histocompatibilidade , Antígenos HLA-A/genética , Sequenciamento de Nucleotídeos em Larga EscalaRESUMO
The novel alleles HLA-DQA1*01:01:01:11 and -DQA1*01:03:01:13 were detected during the routine HLA typing process.
Assuntos
Alelos , Humanos , Cadeias alfa de HLA-DQ/genética , Índia , Teste de Histocompatibilidade , Análise de Sequência de DNARESUMO
The novel HLA-DPA1*01:03:01:64 allele was detected during routine HLA typing.
Assuntos
Cadeias alfa de HLA-DP , Humanos , Alelos , Cadeias alfa de HLA-DP/genética , Teste de Histocompatibilidade , ÍndiaRESUMO
HLA-C*07:04:01:19 differs from C*07:04:01:01 by one nucleotide change in gDNA at position 2420 in intron 5.
Assuntos
Genes MHC Classe I , Antígenos HLA-C , Humanos , Antígenos HLA-C/genética , Alelos , Índia , ÍntronsRESUMO
The novel allele HLA-C*07:02:01:184 as compared with HLA-C*07:02:01:03 displays polymorphism at position; gDNA 2896 (G > C).
Assuntos
Antígenos HLA-C , Humanos , Alelos , Sequência de Bases , Genes MHC Classe I , Sequenciamento de Nucleotídeos em Larga Escala , Antígenos HLA-C/genéticaRESUMO
The novel allele, HLA-B*40:02:01:39 differs from the HLA-B*40:02:01:01 allele by a single nucleotide change at gDNA position 700.
Assuntos
Antígenos HLA-B , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Alelos , Antígenos HLA-B/genética , Genes MHC Classe I , ÍndiaRESUMO
The novel HLA-B*58:01:01:19 allele was characterized using next generation sequencing technology.