[The use of L-lysine aescinat in the treatment of microcirculatory disturbances in patients young and middle age with violation of the intracranial venous outflow]. / L-lizina estsinat v lechenii mikrotsirkulyatornykh rasstroistv pri narushenii intrakranial'nogo venoznogo ottoka u patsientov s sindromom vegetativnoi distonii.

AIM: To study the efficacy of L-lysine aescinat in the treatment of vascular and microvascular disorders in patients with cerebral venous dystonia. MATERIAL AND METHODS: Sixty-eight patients, 25 male and 43 female, aged from 25 to 56 years, with disturbances of venous cerebral blood circulation and venous outflow difficulties were examined. The examination included the assessment of cerebral hemodynamics using the algorithm of complex ultrasound examinations and functional status of the microcirculation by the laser Doppler flowmetry (LDF) at baseline and 10 days after treatment with L-lysine aescinat. RESULTS AND CONCLUSION: L-lysine aescinat improves intracranial venous outflow, significantly improves the functioning of microcirculation, while not affecting the normal type of microcirculation or changing it in the direction of improvement of hemodynamic parameters, has a modulating effect on the autonomic response, and can be recommended in the complex treatment of young and middle aged patients with disturbances of cerebral venous blood circulation with the predominance of vagotonia as well as hypersympathicotonia.

[The classification and topical diagnosis of cerebral circulatory disorders in newborn infants]. / Klassifikatsiia i topicheskaia diagnostika narushenii mozgovogo krovoobrashcheniia u novorozhdennykh detei.

The classification of disorders of cerebral circulation (DCC) was presented on the basis of clinical-neurosonic study of 100 newborn children with the signs of DCC. There were-determined the same degrees of DCC severity as in hypoxic-ischemic encephalopathy (that is light, manifested, severe ones). There weren't observed any signs of focal damages of brain in light form of DCC, although there might sometimes be found the small ischemic damages of brain and injuries of hemorrhagic type in one third of patients. In manifested DCC there were revealed the signs of focal cerebral damages which were caused by combination of hemorrhages in choroid plexus of lateral ventricles and subependymal hemorrhages, and were rarer conditioned by ischemic necrosis of these regions. It was quite characteristic for severe DCC the appearance of pronounced total cerebral disorders just after the birth which might progradiently increase. There were found parenchymatous, subarachnoidal, and intraventricle hemorrhages by means of neurosonography. There was demonstrated the significance of investigation of both muscular tonus and reflexes in newborn children for topic DCC diagnostics.