[Medical and genetic consequences of radiation catastrophies].

The literature data concerning radiation catastrophes that occurred all over the world are analyzed. Causes, scales, clinical and genetic effects are discussed. Special consideration is given to the early and distant consequences of Chernobyl PAS catastrophe.

[Effect of reparation processes on formation of human individual radiosensitivity at the chromosome level].

The results of experimental investigations of the role of DNA repair as the key factor of human individual radiosensitivity formation are presented. It is shown that repair potential of hypersensitive to irradiation individuals is approximately twice lower as compared with the control group.

[Human individual radiosensitivity: cytogenetical aspects].

In accordance with the fundamental principles of the radiation cytogenetics the scheme of cytogenetical examinations of individual radiosensitivity of relatively healthy donors on the basis of chromosomal test (G2-assay) has been developed and tested.

[Types and features of neoplasm resistance].

The types of neoplasm cells resistance to therapeutic agents and causes of its development are described and discussed in the article. The special attention is taken on radioresistance of normal and malignant cells. Resistance peculiarities, modern approaches to make malignant cells more sensitive to therapy as well as determination of tumor sensitivity during treatment and after the treatment are discussed in the article.

[Biological indication and dosimetry of unstable chromosome aberration frequencies in human lymphocytes]. / Biolohichna indykatsiia ta dozymetriia za chastotoiu nestabil'nykh aberatsii khromosom u limfotsytakh liudyny.

Review is devoted to the problems of biological (cytogenetic) dosimetry and indication of degree of radiation lesions based on analysis of unstable chromosome aberrations in lymphocytes of human peripheral blood. Effects of radiation in low doses on human chromosomes and methodology of interpretation of the character of dose cytogenetic curves are discussed. Traditional cytogenetic analysis remains the basic one for monitoring in groups of people with accidental irradiation.

[Treatment of patients wtih malignant lymphoma with freeze-dried cord blood]. / Zastosuvannia kriokonservovanoï kordovoï krovi pry likuvanni khvorykh na zloiakisnu limfomu.

It has been ascertained that in patients with malignant lymphomas, employment of cryopreserved cells of the cord blood (CB) is associated with a high efficiency of therapy of the underlying medical condition. With introduction of CB into the test-system of the donor's blood the T-lymphocytes radiosensitivity has been shown to be increased during the Go- and S-periods of the cell cycle, which fact should be taken account of in planning radiotherapy in oncological patients. A decrease in the level of aneuploid lymphocytes against the background of blast-transformation as a result of transfusion of CB may suggest normalization of the pool of lymphocytes.