RESUMO
Elemental concentrations in whole blood samples from irradiated mice were found [1] to change uncorrelated with the depression of red blood cell count. The aim of the present work was to clear up whether or not similar effects appear in the case of human radiotherapeutic irradiations. Concentration ratios were taken for erythrocyte and plasma fractions with the proton induced X-ray emission method for the elements P, K, Ca, Fe, Zn in the case of patients undergoing postoperative gamma irradiation following mastectomy. None of the concentration ratios were found to be influenced under the present conditions of irradiation.
Assuntos
Análise Química do Sangue , Radioisótopos de Cobalto/efeitos adversos , Eritrócitos/análise , Teleterapia por Radioisótopo/efeitos adversos , Neoplasias da Mama/radioterapia , Cálcio/sangue , Feminino , Raios gama , Humanos , Ferro/sangue , Fósforo/sangue , Potássio/sangue , Espectrometria por Raios X , Zinco/sangueRESUMO
D-Penicillamine, previously suspected to have a beneficial effect on the occurrence of severe retrolental fibroplasia among very low birth weight infants, was tested to determine the extent to which this drug modifies acute radiosensitivity on 3- to 4-day-old mice in comparison with adult animals. It was found that the radioprotective effect of penicillamine, given in doses of 3,000 mg/kg i.p. 60 min before whole-body exposure to 6-10 Gy of 60Co gamma rays, was greater in 3- to 4-day-old mice than in adult animals. These data seem to be compatible with the view that D-penicillamine, by virtue of its antioxidant action, may reduce the toxic effects associated with exposure of the newborn infant to hyperoxia, specifically retrolental fibroplasia and bronchopulmonary dysplasia.
Assuntos
Envelhecimento , Penicilamina/farmacologia , Protetores contra Radiação , Animais , Animais Recém-Nascidos/fisiologia , Dose Letal Mediana , Masculino , Camundongos , Fatores de TempoRESUMO
The authors are presenting the 5-year survival rates of 170 patients treated for carcinoma of the lip at the radiological department of the Medical University in Debrecen. The results of radiation therapy, clarified and stage-correlated, are as follows: T1 100%, T2 90.2%, T3 67.9%. They call attention to the fact that in planning and carrying out the schedule of radiation treatment its effectiveness is stage-dependent. In radiation treatment applied in conformity with this, the basic laws of radiation therapy have to be observed. In the treatment of Stages T1 the optimal added-up radiation effectiveness lies at 2000 to 2500 reu with Chaoul tubes 1 and 2, for Stages T2 at 2300 to 2600 reu with Chaoul tubes 3 and 4, for Stages T3 at 2500 to 2600 reu with Chaoul tubes 3, 6 or 10 and additional telecobalt irradiation of the corresponding lymphatic chains.
