On a deterministic mathematical model which efficiently predicts the protective effect of a plant extract mixture in cirrhotic rats.

In this work, we propose a mathematical model that describes liver evolution and concentrations of alanine aminotransferase and aspartate aminotransferase in a group of rats damaged with carbon tetrachloride. Carbon tetrachloride was employed to induce cirrhosis. A second groups damaged with carbon tetrachloride was exposed simultaneously a plant extract as hepatoprotective agent. The model reproduces the data obtained in the experiment reported in [Rev. Cub. Plant. Med. 22(1), 2017], and predicts that using the plants extract helps to get a better natural recovery after the treatment. Computer simulations show that the extract reduces the damage velocity but does not avoid it entirely. The present paper is the first report in the literature in which a mathematical model reliably predicts the protective effect of a plant extract mixture in rats with cirrhosis disease. The results reported in this manuscript could be used in the future to help in fighting cirrhotic conditions in humans, though more experimental and mathematical work is required in that case.

Dynamics of a cross-superdiffusive SIRS model with delay effects in transmission and treatment.

We investigate the dynamics of a SIRS epidemiological model taking into account cross-superdiffusion and delays in transmission, Beddington-DeAngelis incidence rate and Holling type II treatment. The superdiffusion is induced by inter-country and inter-urban exchange. The linear stability analysis for the steady-state solutions is performed, and the basic reproductive number is calculated. The sensitivity analysis of the basic reproductive number is presented, and we show that some parameters strongly influence the dynamics of the system. A bifurcation analysis to determine the direction and stability of the model is carried out using the normal form and center manifold theorem. The results reveal a proportionality between the transmission delay and the diffusion rate. The numerical results show the formation of patterns in the model, and their epidemiological implications are discussed.

A multiconsistent computational methodology to resolve a diffusive epidemiological system with effects of migration, vaccination and quarantine.

BACKGROUND: We provide a compartmental model for the transmission of some contagious illnesses in a population. The model is based on partial differential equations, and takes into account seven sub-populations which are, concretely, susceptible, exposed, infected (asymptomatic or symptomatic), quarantined, recovered and vaccinated individuals along with migration. The goal is to propose and analyze an efficient computer method which resembles the dynamical properties of the epidemiological model. MATERIALS AND METHODS: A non-local approach is utilized for finding approximate solutions for the mathematical model. To that end, a non-standard finite-difference technique is introduced. The finite-difference scheme is a linearly implicit model which may be rewritten using a suitable matrix. Under suitable circumstances, the matrices representing the methodology are M-matrices. RESULTS: Analytically, the local asymptotic stability of the constant solutions is investigated and the next generation matrix technique is employed to calculate the reproduction number. Computationally, the dynamical consistency of the method and the numerical efficiency are investigated rigorously. The method is thoroughly examined for its convergence, stability, and consistency. CONCLUSIONS: The theoretical analysis of the method shows that it is able to maintain the positivity of its solutions and identify equilibria. The method's local asymptotic stability properties are similar to those of the continuous system. The analysis concludes that the numerical model is convergent, stable and consistent, with linear order of convergence in the temporal domain and quadratic order of convergence in the spatial variables. A computer implementation is used to confirm the mathematical properties, and it confirms the ability in our scheme to preserve positivity, and identify equilibrium solutions and their local asymptotic stability.

The Effect of On-Site Potentials on Supratransmission in One-Dimensional Hamiltonian Lattices.

We investigated a class of one-dimensional (1D) Hamiltonian N-particle lattices whose binary interactions are quadratic and/or quartic in the potential. We also included on-site potential terms, frequently considered in connection with localization phenomena, in this class. Applying a sinusoidal perturbation at one end of the lattice and an absorbing boundary on the other, we studied the phenomenon of supratransmission and its dependence on two ranges of interactions, 0<α<∞ and 0<ß<∞, as the effect of the on-site potential terms of the Hamiltonian varied. In previous works, we studied the critical amplitude As(α,Ω) at which supratransmission occurs, for one range parameter α, and showed that there was a sharp threshold above which energy was transmitted in the form of large-amplitude nonlinear modes, as long as the driving frequency Ω lay in the forbidden band-gap of the system. In the absence of on-site potentials, it is known that As(α,Ω) increases monotonically the longer the range of interactions is (i.e., as α⟶0). However, when on-site potential terms are taken into account, As(α,Ω) reaches a maximum at a low value of α that depends on Ω, below which supratransmission thresholds decrease sharply to lower values. In this work, we studied this phenomenon further, as the contribution of the on-site potential terms varied, and we explored in detail their effect on the supratransmission thresholds.

An Interleaved Segmented Spectrum Analysis: A Measurement Technique for System Frequency Response and Fault Detection.

A frequency spectrum segmentation methodology is proposed to extract the frequency response of circuits and systems with high resolution and low distortion over a wide frequency range. A high resolution is achieved by implementing a modified Dirichlet function (MDF) configured for multi-tone excitation signals. Low distortion is attained by limiting or avoiding spectral leakage and interference into the frequency spectrum of interest. The use of a window function allowed for further reduction in distortion by suppressing system-induced oscillations that can cause severe interference while acquiring signals. This proposed segmentation methodology with the MDF generates an interleaved frequency spectrum segment that can be used to measure the frequency response of the system and can be represented in a Bode and Nyquist plot. The ability to simulate and measure the frequency response of the circuit and system without expensive network analyzers provides good stability coverage for reliable fault detection and failure avoidance. The proposed methodology is validated with both simulation and hardware.

An efficient nonstandard computer method to solve a compartmental epidemiological model for COVID-19 with vaccination and population migration.

BACKGROUND AND OBJECTIVE: In this manuscript, we consider a compartmental model to describe the dynamics of propagation of an infectious disease in a human population. The population considers the presence of susceptible, exposed, asymptomatic and symptomatic infected, quarantined, recovered and vaccinated individuals. In turn, the mathematical model considers various mechanisms of interaction between the sub-populations in addition to population migration. METHODS: The steady-state solutions for the disease-free and endemic scenarios are calculated, and the local stability of the equilibium solutions is determined using linear analysis, Descartes' rule of signs and the Routh-Hurwitz criterion. We demonstrate rigorously the existence and uniqueness of non-negative solutions for the mathematical model, and we prove that the system has no periodic solutions using Dulac's criterion. To solve this system, a nonstandard finite-difference method is proposed. RESULTS: As the main results, we show that the computer method presented in this work is uniquely solvable, and that it preserves the non-negativity of initial approximations. Moreover, the steady-state solutions of the continuous model are also constant solutions of the numerical scheme, and the stability properties of those solutions are likewise preserved in the discrete scenario. Furthermore, we establish the consistency of the scheme and, using a discrete form of Gronwall's inequality, we prove theoretically the stability and the convergence properties of the scheme. For convenience, a Matlab program of our method is provided in the appendix. CONCLUSIONS: The computer method presented in this work is a nonstandard scheme with multiple dynamical and numerical properties. Most of those properties are thoroughly confirmed using computer simulations. Its easy implementation make this numerical approach a useful tool in the investigation on the propagation of infectious diseases. From the theoretical point of view, the present work is one of the few papers in which a nonstandard scheme is fully and rigorously analyzed not only for the dynamical properties, but also for consistently, stability and convergence.

A dynamically consistent computational method to solve numerically a mathematical model of polio propagation with spatial diffusion.

BACKGROUND AND OBJECTIVE: In this work, a mathematical model based on differential equations is proposed to describe the propagation of polio in a human population. The motivating system is a compartmental nonlinear model which is based on the use of ordinary differential equations and four compartments, namely, susceptible, exposed, infected and vaccinated individuals. METHODS: In this manuscript, the mathematical model is extended in order to account for spatial diffusion in one dimension. Nonnegative initial conditions are used, and we impose homogeneous Neumann conditions at the boundary. We determine analytically the disease-free and the endemic equilibria of the system along with the basic reproductive number. RESULTS: We establish thoroughly the nonnegativity and the boundedness of the solutions of this problem, and the stability analysis of the equilibrium solutions is carried out rigorously. In order to confirm the validity of these results, we propose an implicit and linear finite-difference method to approximate the solutions of the continuous model. CONCLUSIONS: The numerical model is stable in the sense of von Neumann, it yields consistent approximations to the exact solutions of the differential problem, and that it is capable of preserving unconditionally the positivity of the approximations. For illustration purposes, we provide some computer simulations that confirm some theoretical results derived in the present manuscript.

Development of Nano-Antifungal Therapy for Systemic and Endemic Mycoses.

Fungal mycoses have become an important health and environmental concern due to the numerous deleterious side effects on the well-being of plants and humans. Antifungal therapy is limited, expensive, and unspecific (causes toxic effects), thus, more efficient alternatives need to be developed. In this work, Copper (I) Iodide (CuI) nanomaterials (NMs) were synthesized and fully characterized, aiming to develop efficient antifungal agents. The bioactivity of CuI NMs was evaluated using Sporothrix schenckii and Candida albicans as model organisms. CuI NMs were prepared as powders and as colloidal suspensions by a two-step reaction: first, the CuI2 controlled precipitation, followed by hydrazine reduction. Biopolymers (Arabic gum and chitosan) were used as surfactants to control the size of the CuI materials and to enhance its antifungal activity. The materials (powders and colloids) were characterized by SEM-EDX and AFM. The materials exhibit a hierarchical 3D shell morphology composed of ordered nanostructures. Excellent antifungal activity is shown by the NMs against pathogenic fungal strains, due to the simultaneous and multiple mechanisms of the composites to combat fungi. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of CuI-AG and CuI-Chitosan are below 50 µg/mL (with 5 h of exposition). Optical and Atomic Force Microscopy (AFM) analyses demonstrate the capability of the materials to disrupt biofilm formation. AFM also demonstrates the ability of the materials to adhere and penetrate fungal cells, followed by their lysis and death. Following the concept of safe by design, the biocompatibility of the materials was tested. The hemolytic activity of the materials was evaluated using red blood cells. Our results indicate that the materials show an excellent antifungal activity at lower doses of hemolytic disruption.

Numerical modeling and theoretical analysis of a nonlinear advection-reaction epidemic system.

BACKGROUND AND OBJECTIVE: Epidemic models are used to describe the dynamics of population densities or population sizes under suitable physical conditions. In view that population densities and sizes cannot take on negative values, the positive character of those quantities is an important feature that must be taken into account both analytically and numerically. In particular, susceptible-infected-recovered (SIR) models must also take into account the positivity of the solutions. Unfortunately, many existing schemes to study SIR models do not take into account this relevant feature. As a consequence, the numerical solutions for these systems may exhibit the presence of negative population values. Nowadays, positivity (and, ultimately, boundedness) is an important characteristic sought for in numerical techniques to solve partial differential equations describing epidemic models. METHOD: In this work, we will develop and analyze a positivity-preserving nonstandard implicit finite-difference scheme to solve an advection-reaction nonlinear epidemic model. More concretely, this discrete model has been proposed to approximate consistently the solutions of a spatio-temporal nonlinear advective dynamical system arising in many infectious disease phenomena. RESULTS: The proposed scheme is capable of guaranteeing the positivity of the approximations. Moreover, we show that the numerical scheme is consistent, stable and convergent. Additionally, our finite-difference method is capable of preserving the endemic and the disease-free equilibrium points. Moreover, we will establish that our methodology is stable in the sense of von Neumann. CONCLUSION: Comparisons with existing techniques show that the technique proposed in this work is a reliable and efficient structure-preserving numerical model. In summary, the present approach is a structure-preserving and efficient numerical technique which is easy to implement in any scientific language by any scientist with minimal knowledge on scientific programming.

Diffusive instabilities in a hyperbolic activator-inhibitor system with superdiffusion.

We investigate analytically and numerically the conditions for wave instabilities in a hyperbolic activator-inhibitor system with species undergoing anomalous superdiffusion. In the present work, anomalous superdiffusion is modeled using the two-dimensional Weyl fractional operator, with derivative orders α∈ [1,2]. We perform a linear stability analysis and derive the conditions for diffusion-driven wave instabilities. Emphasis is placed on the effect of the superdiffusion exponent α, the diffusion ratio d, and the inertial time τ. As the superdiffusive exponent increases, so does the wave number of the Turing instability. Opposite to the requirement for Turing instability, the activator needs to diffuse sufficiently faster than the inhibitor in order for the wave instability to occur. The critical wave number for wave instability decreases with the superdiffusive exponent and increases with the inertial time. The maximum value of the inertial time for a wave instability to occur in the system is τ_{max}=3.6. As one of the main results of this work, we conclude that both anomalous diffusion and inertial time influence strongly the conditions for wave instabilities in hyperbolic fractional reaction-diffusion systems. Some numerical simulations are conducted as evidence of the analytical predictions derived in this work.

Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells.

Expression of the scaffolding protein Caveolin-1 (CAV1) enhances migration and invasion of metastatic cancer cells. Yet, CAV1 also functions as a tumor suppressor in early stages of cancer, where expression is suppressed by epigenetic mechanisms. Thus, we sought to identify stimuli/mechanisms that revert epigenetic CAV1 silencing in cancer cells and evaluate how this affects their metastatic potential. We reasoned that restricted tissue availability of anti-neoplastic drugs during chemotherapy might expose cancer cells to sub-therapeutic concentrations, which activate signaling pathways and the expression of CAV1 to favor the acquisition of more aggressive traits. Here, we used in vitro [2D, invasion] and in vivo (metastasis) assays, as well as genetic and biochemical approaches to address this question. Colon and breast cancer cells were identified where CAV1 levels were low due to epigenetic suppression and could be reverted by treatment with the methyltransferase inhibitor 5'-azacytidine. Exposure of these cells to anti-neoplastic drugs for short periods of time (24-48 h) increased CAV1 expression through ROS production and MEK/ERK activation. In colon cancer cells, increased CAV1 expression enhanced migration and invasion in vitro via pathways requiring Src-family kinases, as well as Rac-1 activity. Finally, elevated CAV1 expression in colon cancer cells following exposure in vitro to sub-cytotoxic drug concentrations increased their metastatic potential in vivo. Therefore exposure of cancer cells to anti-neoplastic drugs at non-lethal drug concentrations induces signaling events and changes in transcription that favor CAV1-dependent migration, invasion and metastasis. Importantly, this may occur in the absence of selection for drug-resistance.

Estudio de la situación socioeconómica y académica del docente de la Facultad de Medicina de la Universidad Peruana Cayetano Heredia / Study of the social, economic and academic situation of the professor of the Faculty of Medicine in the Universidad Peruana Cayetano Heredia

Una muestra de 121 docentes, 51.3 por ciento del total, de la Facultad de Medicina Alberto Hurtado de la UPCH fue encuestada con el objeto de conocer sus características sociales, económicas y académicas. Hallamos: promedio de edad: 49.4 años; 89.3 por ciento varones; 87.6 por ciento casados; 85.8 residían en distritos de nivel medio y alto; promedio de 2.8 hijos; 8.3 por ciento a dedicación exclusiva o tiempo completo; promedio de 19.5 años en la docencia; 95.9 por ciento hacían docencia por atracción; 85.1 por ciento no la dejarían; 42.4 por ciento se sentían satisfechos; 52.9 por ciento tenían capacitación en tecnología educativa; 54.5 por ciento investigaba; 55.9 por ciento publicaba; 90.0 por ciento trabajaba para el Ministerio de Salud; 79.2 por ciento hacía práctica privada; 75.0 por ciento tenía casa propia; 52.5 por ciento tenía familiares que generaban ingresos y 72.5 por ciento tenía la práctica privada como principal fuente de ingreso. se concluye que nuestros docentes en promedio son de nivel socioeconómico medio, realizan la docencia como actividad complementaria, tienen vocación por la enseñanza y mucha experiencia, más no suficiente formación pedagógica y que podrían incrementar la investigación y publicaciones

A study of VIIIC and VIICAg in normals and hemophilia a patients in a brazilian population

Quarenta indivíduos normais (20 mulheres e 20 homens) e 93 pacientes com hemofilia A pertencentes a 72 famílias foram examinados quanto à atividade coagulante de fator VIII (VIIIC) pelo método em um estágio e quanto ao antígeno relacionado ao fator VIII (VIIICAg) pelo método de neutralizaçäo de inibidor. Entre os hemofílicos, a razäo VIIIC/VIIIcAg permitiu classificar 12 paciente como A+ (12,9%) e 81 como A-(87.1%). Nos normais näo foi encontrada diferença significante entre sexos quanto aos níveis médios de VIIIC, o mesmo ocorrendo quanto aos níveis médios de VIIICAg. Correlaçäo significante entre níveis de VIIIC e VIIICAg foi observada em indivíduos normais e em pacientes A- mas näo em pacientes A+. As médias de VIIIC dos dois grupos de pacientes näo foram diferentes mas a média de VIIICAg do grupo A+ era significantemente mais elevada. A distribuiçäo dos tipo A+ e A- em familias nas quais a hemofilia era esporádica e naquelas em que era recorrente foi semelhante. O tipo de hemofilia foi concordante em todas as famílias nas quais mais de um paciente pôde ser examinado

Portal de seguridad para control de acceso a recintos y/o areas de alta seguridad

El diseño de un Portal de Seguridad para control de acceso a recintos y/o areas de alta seguridad, orientado al control de acceso a las bovedas de Banco Central de Bolivia.Diseñar un sistema de control autmatico para la apertura y cierre de la puerta de ingreso a la Boveda del BCB que permita el acceso de personas autorizadas.Este sistema fundamenta su actividad en el reconocimiento de la huella dactilar a traves de la Biometria de Huellas Dactilares. Incrementar la seguridad del sistema incluyendo otros parametros de control como ser el registro de la fotografia de la persona que ingresa, y la posibilidad de realizar una verificacion adicional a traves de la Biometria de Reconocimiento facial, se incluira tambien el registro de la estatura y peso, con el fin de poder realizar comparaciones adicionales con una base de datos establecida.Controlar las autorizaciones de ingreso desde un punto remoto sin permitir la intervencion de terceros.Obtener una base de datos de todos y cada una de los eventos que suceden, con todos los detalles que se toman en cuentan en el control de ingresos y disponible en cualquier momento.